| S Owen Property Rentals Limited | Real estate | 2014 |
| S R Rigging & Lifting Services Ltd | Construction | 2024 |
| S R Rigging Services Limited | Construction | 2025 |
| S Robinson Contracts Limited | Construction | 2020 |
| S Siddle Rigging & Lifting Ltd | Construction | 2025 |
| S T Properties & Lettings Ltd | Real estate | 2021 |
| S W Plumbing and Heating (North East) Ltd | Construction | 2017 |
| S Williams NE Limited | Construction | 2021 |
| S Wilson Decorators Limited | Professional & scientific | 2016 |
| S&D Property Housing Ltd | Real estate | 2025 |
| S&G Courier Ltd | Transport & logistics | 2026 |
| S&H Services (South East) Limited | Construction | 2025 |
| S&J Northern Limited | Wholesale & retail | 2023 |
| S&M Grig Service Ltd | Manufacturing | 2019 |
| S&M Properties & Developments Ltd | Real estate | 2024 |
| S&N Housing Ltd | Real estate | 2024 |
| S&S Facilities Services Ltd | Construction | 2023 |
| S&W Rigging Ltd | Construction | 2024 |
| S-Bee Properties Ltd | Real estate | 2026 |
| S.A.S Renewables Ltd | Professional & scientific | 2020 |
| S.Duncan Electrical Limited | Administrative & support | 2015 |
| S.E.C. Engineering (North East) Ltd | Professional & scientific | 2011 |
| S.E.L.69 Ltd | Other services | 2018 |
| S.K.A Consultants Ltd | Public administration | 2025 |
| S.M.Thompson Limited | Wholesale & retail | 1950 |
| S.P. E. & I. Services Limited | Professional & scientific | 2013 |
| S.S Heritage Builders Limited | Construction | 2020 |
| S.T.M Upskill Assist Limited | Education | 2025 |
| S.W.C Consultancy Services Limited | Construction | 2023 |
| S2 36 Frederick Street Limited | Construction | 2022 |
| S2 438 Linthorpe Ltd | Construction | 2022 |
| S2 5662 Borough Road Limited | Construction | 2022 |
| S2 Ayresome Limited | Construction | 2022 |
| S2 Ayresome Road Limited | Construction | 2025 |
| S2 Crescent Road Limited | Construction | 2024 |
| S2 Deltic Limited | Construction | 2022 |
| S2 Framlington Limited | Construction | 2024 |
| S2 John Street Limited | Construction | 2018 |
| S2 Norton Limited | Construction | 2022 |
| S2C Architects Limited | Professional & scientific | 2013 |
| SA Embroidery Limited | Other services | 2002 |
| SA Industrial’S Ltd | Administrative & support | 2023 |
| SA Property Buyers Ltd | Construction | 2025 |
| SA Vision Investments Ltd | Real estate | 2025 |
| SA11 Khan Limited | Mining & quarrying | 2021 |
| Saab Materials Limited | Wholesale & retail | 2025 |
| Saad Sultan Ltd | Transport & logistics | 2025 |
| Saad Technical Ltd | Transport & logistics | 2018 |
| Saami Properties Ltd | Construction | 2021 |
| Saber Housing Development Ltd | Construction | 2023 |
| Sabre Accountants FFA Ltd | Professional & scientific | 2018 |
| Sabre Fleet Claims Ltd | Administrative & support | 2021 |
| Sacred Fury Ltd | Arts & recreation | 2025 |
| Saen El-Tara Care Services Ltd | Administrative & support | 2023 |
| Safari Commercial Limited | Real estate | 2026 |
| Safe Choice Consultancy Limited | Mining & quarrying | 2019 |
| Safe Hands Engineering Ltd | Construction | 2017 |
| Safe Work Consulting Ltd | Other services | 2024 |
| Safetreat Ltd | Professional & scientific | 2025 |
| Safety & Quality Consultancy Limited | Professional & scientific | 2021 |
| Safety and Risk Management Limited | Professional & scientific | 2002 |
| Safety First Supplies Ltd | Wholesale & retail | 2011 |
| Safety Innovations Limited | Professional & scientific | 2024 |
| Safety Inspectors UK Ltd | Professional & scientific | 2021 |
| Safety POD International Ltd | Manufacturing | 2024 |
| Safety Risk Solutions Ltd | Professional & scientific | 2021 |
| Safety Services NE Limited | Professional & scientific | 2020 |
| Safetyscope Limited | Professional & scientific | 2020 |
| Saffron & Co. Limited | Hospitality | 2026 |
| Saffron (B Auckland) Ltd | Hospitality | 2019 |
| Saffron-Rose Ltd | Other services | 2018 |
| SAG Hussain Retail Ltd | Wholesale & retail | 2026 |
| SAH Lifting Limited | Professional & scientific | 2022 |
| Sahb Ltd | Wholesale & retail | 2022 |
| Saif House Ltd | Real estate | 2024 |
| Sajker Ltd | Manufacturing | 2025 |
| SAK Asset Management Limited | Real estate | 2015 |
| Sakhi Enterprises Ltd | Professional & scientific | 2024 |
| Salam Clothing Ltd | Wholesale & retail | 2024 |
| Sales Fitness Group Limited | Administrative & support | 2011 |
| Salesfire Ltd | Information & communication | 2018 |
| Saliha Holdings Limited | Financial services | 2023 |
| Salina Iqbal Ltd | Real estate | 2021 |
| Salis Design Limited | Professional & scientific | 2022 |
| Salis Holdings NE Ltd | Construction | 2023 |
| Salon B Hairdressing Ltd | Other services | 2023 |
| Salon Dolls Ltd | Wholesale & retail | 2024 |
| Salon Romania M Ltd | Other services | 2025 |
| Salt Recording Ltd | Information & communication | 2024 |
| Saltburn Consulting Limited | Professional & scientific | 2025 |
| Saltburn Cottages Ltd | Hospitality | 2021 |
| Saltburn Miniature Railway Limited | Transport & logistics | 2016 |
| Saltburn&Catering Ltd | Hospitality | 2026 |
| Salvify Limited | Information & communication | 2024 |
| Salvin & SON Ltd | Other services | 2020 |
| SAM Business Solutions Limited | Professional & scientific | 2026 |
| SAM H Property Ltd | Real estate | 2025 |
| SAM Holtby Limited | Agriculture & fishing | 2018 |
| SAM Judge Studio Limited | Professional & scientific | 2018 |
| SAM Medicare Ltd | Health & social care | 2026 |