| Duofix Ltd | Construction | 2023 |
| Durability North Community Interest Company | Hospitality | 2021 |
| Duranta Energy Limited | Professional & scientific | 2012 |
| Duranta Energy Services Limited | Energy | 2012 |
| Duranta Teesside Limited | Energy | 2012 |
| Durata Fabrication Ltd | Manufacturing | 2014 |
| Durata Group Ltd | Financial services | 2024 |
| Durata UK Ltd | Manufacturing | 2013 |
| Durham Grange Estates Limited | Financial services | 2019 |
| Durham Hair Loss Clinic by JDK Ltd | Other services | 2025 |
| Durham Lifting Limited | Manufacturing | 1996 |
| Durham Lifting Training Solutions Ltd | Education | 2023 |
| Durrant Property Ltd | Construction | 2026 |
| Dutton Mechanical Engineering Limited | Professional & scientific | 2019 |
| DW Conservatories Ltd | Construction | 2025 |
| DW Industrial Limited | Professional & scientific | 2014 |
| DW Instruments Ltd | Administrative & support | 2022 |
| DW International Trading Ltd | Wholesale & retail | 2024 |
| DW Properties NE Limited | Real estate | 2023 |
| DW Rentals (NE) Ltd | Real estate | 2025 |
| DW Tate Logistics Limited | Transport & logistics | 2025 |
| DWB Engineering Solutions Limited | Manufacturing | 2019 |
| Dwfa Properties Limited | Real estate | 2024 |
| Dwss Ltd | Construction | 2024 |
| DXC Geological Ltd | Mining & quarrying | 2017 |
| Dympna Leisure Ltd | Hospitality | 2023 |
| Dynamic Cctv Limited | Administrative & support | 1994 |
| Dynamic Technology Solutions Limited | Financial services | 2015 |
| Dynamicads Limited | Information & communication | 2003 |
| Dynamo Kings Limited | Professional & scientific | 2016 |
| Dynamo Vision Ltd | Information & communication | 2020 |
| E & a Properties Limited | Real estate | 2021 |
| E & C Offshore Limited | Construction | 2012 |
| E & I Developments Limited | Construction | 2012 |
| E & S Safety Ltd | Administrative & support | 2025 |
| E Travel North East Ltd | Transport & logistics | 2018 |
| E&I I W Nicholas Limited | Construction | 2016 |
| E-Wire Northern Limited | Construction | 2009 |
| E.A Lords Investment Limited | Real estate | 2024 |
| E.E.M.I.T.S. Communications Limited | Information & communication | 1992 |
| E.L.S. Scaffolding Ltd | Construction | 2014 |
| E.Q. Equity Ltd | Construction | 2025 |
| E.Stacy Marks Limited | Wholesale & retail | 1932 |
| E2 Motors Ltd | Wholesale & retail | 2024 |
| EA Healthcare & Security Services Ltd | Health & social care | 2023 |
| EA IT Solutions Ltd | Information & communication | 2021 |
| Eaccountax Limited | Professional & scientific | 2021 |
| Eagle MOT Centre Limited | Wholesale & retail | 2011 |
| Eagle Security & Surveillance Ltd | Information & communication | 2025 |
| Eagle Security NE Ltd | Administrative & support | 2023 |
| EAR Clear Hearing Care Holdings Limited | Health & social care | 2025 |
| Early Bird Renovations Ltd | Real estate | 2019 |
| Earwax and Aesthetic Solutions North East Ltd | Professional & scientific | 2021 |
| Easby Cottages Ltd | Hospitality | 2021 |
| Easton Functional Safety Training and Services Limited | Professional & scientific | 2014 |
| Eastons Electrical Ltd | Construction | 2026 |
| Eastwood Retail Limited | Wholesale & retail | 2024 |
| Easy Gym (SW) Limited | Arts & recreation | 2011 |
| Easybasket Ltd | Wholesale & retail | 2026 |
| Easyletsproperties Ltd | Real estate | 2024 |
| Easyway Property Services Ltd | Real estate | 2024 |
| Eatwithade Limited | Hospitality | 2025 |
| Eauk Property Services Ltd | Construction | 2019 |
| EAY Removals Limited | Transport & logistics | 2024 |
| Eazybuild Ltd | Other services | 2018 |
| Eazygroup Developments Ltd | Other services | 2019 |
| Eazylaw Ltd | Other services | 2016 |
| Eazylet (North East) Ltd | Other services | 2019 |
| Eazylet Lettings Ltd | Other services | 2016 |
| Eazyliving for Students Ltd | Other services | 2018 |
| Eazymove Estate Agents Ltd | Other services | 2016 |
| Eazymove Property Auctions Ltd | Real estate | 2018 |
| Eazysearch Ltd | Other services | 2018 |
| Ebbswood Ltd | Water & waste | 2023 |
| EC Industrial Solutions Ltd | Construction | 2024 |
| Ecco Finishing Supplies Holdings Limited | Wholesale & retail | 2016 |
| Ecco Finishing Supplies Limited | Wholesale & retail | 1995 |
| Echo of Hope CIC | Education | 2025 |
| Echo Pubs Ltd | Hospitality | 2026 |
| Eclipse ICT Limited | Information & communication | 2013 |
| ECN1 Landlord Limited | Real estate | 2018 |
| Eco Chic 2024 CIC | Water & waste | 2024 |
| Eco Fencing (London) Limited | Construction | 2016 |
| Eco Lodge Cabins Ltd | Construction | 2011 |
| Eco-Cigarette Ltd | Wholesale & retail | 2017 |
| Eco-Trailer Limited | Transport & logistics | 2017 |
| Ecocert UK Limited | Professional & scientific | 2026 |
| Ecomine Ltd | Information & communication | 2019 |
| Ecomiva Limited | Wholesale & retail | 2025 |
| Ecommerce Grove Ltd | Wholesale & retail | 2025 |
| Ecommerce Ventures Ltd | Wholesale & retail | 2025 |
| Econnect Ltd | Wholesale & retail | 2026 |
| ED Psychology Services Limited | Education | 2021 |
| Ed's Vending Ltd | Wholesale & retail | 2023 |
| Ed-Wood Limited | Professional & scientific | 2021 |
| Eden House Properties Ltd | Real estate | 2018 |
| Edgenet Ltd | Construction | 2023 |
| Edgewick Consultancy Limited | Professional & scientific | 2019 |
| Educere Development Agency UK CIC | Education | 2026 |
| Edwardian Residential Care Homes Limited | Health & social care | 2002 |