| Ultima Floors Limited | Other services | 2004 |
| UNIAXIAL@58 Limited | Health & social care | 2017 |
| Unilever PLC | Professional & scientific | 1894 |
| Unitquest Property Management Limited | Households | 1987 |
| Universal Arches (Holdings) Limited | Professional & scientific | 2006 |
| Universal Lighting Services Limited | Wholesale & retail | 1970 |
| Univille Builders Limited | Real estate | 2015 |
| Upload Your Business Limited | Information & communication | 2005 |
| Upton Builders Limited | | 1982 |
| Urban Monkey Ltd | Construction | 2003 |
| USS Investment Management Limited | Financial services | 1997 |
| V & Y Limited | Hospitality | 2003 |
| V.J. Health & Medical Limited | Health & social care | 2002 |
| Vale UK Limited | Construction | 1978 |
| Valley Community Theatre | Arts & recreation | 1999 |
| Variety Christmas Club Holdings Limited | Extraterritorial | 2006 |
| Variety Christmas Savings Club Limited | Financial services | 1985 |
| Variety Gift Vouchers Limited | Extraterritorial | 1991 |
| Vauxcare Wirral Limited | Wholesale & retail | 2006 |
| Vehicle Assessment Services Limited | Professional & scientific | 2000 |
| Veritas Analysis Limited | Information & communication | 2011 |
| Versatile Plant Investment Limited | Professional & scientific | 1988 |
| Victoria Park Management Company (Southport) Limited | Real estate | 1995 |
| Viking Centre & Youth Club Limited | Health & social care | 2003 |
| Virginia Street Garage Ltd | Wholesale & retail | 2007 |
| Vitalprofit Ltd | Professional & scientific | 2011 |
| Voxcar Limited | Extraterritorial | 2011 |
| W D C Services & Maintenance Limited | Construction | 2002 |
| W E Jones & SON (Liverpool) Limited | Administrative & support | 2006 |
| W&T Nettleton Limited | Extraterritorial | 2005 |
| W. Hall & SON (Holywell) Limited | Wholesale & retail | 2008 |
| W. Swindells & SON (Roofing) Limited | Construction | 1976 |
| W.J.Defty Limited | Hospitality | 2002 |
| W.P.J. Manufacturers (Liverpool) Limited | | 1974 |
| W.T. Solutions Limited | Information & communication | 1998 |
| Walker Etrading Limited | Wholesale & retail | 2006 |
| Wallace Medical Limited | Health & social care | 2018 |
| Wallasey Golf Club Limited(The) | Arts & recreation | 1929 |
| Walsh Auto Engineering Limited | Wholesale & retail | 1981 |
| Walton Glass Limited | Construction | 1983 |
| Warren Park Nursing Home Limited | Health & social care | 2001 |
| Warwick Development (North West) Limited | Manufacturing | 1998 |
| Waterville Investments Limited | Real estate | 2003 |
| Wavertree City Car Wash Ltd | Administrative & support | 2023 |
| Wavertree Property Link (N.W.) Limited | Real estate | 2006 |
| WEBBTECH1 Limited | Information & communication | 2024 |
| Website Concepts Limited | Information & communication | 1997 |
| Wedocommercial Ltd | Transport & logistics | 2024 |
| Weldall Engineering Limited | Professional & scientific | 1940 |
| Wellington WBL Ltd | Financial services | 2025 |
| West Coast Electrical Services Limited | Construction | 2004 |
| West Coast Thermal Insulation Limited | Professional & scientific | 1994 |
| West Lancashire Fabrications Ltd | Manufacturing | 2022 |
| West Lancashire Woodscrews Limited | | 1983 |
| West Lancs Paint & Varnish Co Limited | Manufacturing | 1997 |
| West View Health Services Limited | Health & social care | 2009 |
| Wetherford Limited | Real estate | 2003 |
| Whiston Social Limited | Hospitality | 2008 |
| Whitechapel Enterprises Limited | Real estate | 1994 |
| Whitewater Country Parks Ltd | Hospitality | 2006 |
| Whittle Properties (NW) Ltd | Real estate | 2020 |
| Widnes Bathrooms & Kitchens Ltd | Wholesale & retail | 2011 |
| Wilcock Electrical Supplies Limited | Wholesale & retail | 2004 |
| William Clarke (Greengrocers) Limited | Wholesale & retail | 1960 |
| William S Thompson Limited | Wholesale & retail | 2006 |
| Williams Clean* Limited | Other services | 2005 |
| Willow Maintenance Limited | Administrative & support | 2006 |
| Willow Printing and Design Limited | Manufacturing | 2002 |
| Willowbrook Hospice | Health & social care | 1993 |
| Wilpshire Medical Services Limited | Health & social care | 2013 |
| Wilsons Financial Solutions Ltd | Financial services | 2000 |
| Windle Bowling Club Limited(The) | Arts & recreation | 1894 |
| Windsors (Wallasey) Limited | Wholesale & retail | 1935 |
| Winning Hand C.I.C. | Education | 2008 |
| Wirral Christian Centre Trust Limited | Health & social care | 1987 |
| Wirral Cold Store Limited | Professional & scientific | 1985 |
| Wirral Concrete Limited | Wholesale & retail | 1985 |
| Wirral Hire Limited | Administrative & support | 1985 |
| Wirral Mind | Other services | 1997 |
| Wirral Thermal Insulations Limited | Wholesale & retail | 1971 |
| WJ Riddiough Transport Limited | Transport & logistics | 2007 |
| WJW Limited | Professional & scientific | 2000 |
| Women's Enterprising Breakthrough | Health & social care | 1995 |
| Woodbyrne Properties Limited | Households | 1998 |
| Woodhey Joinery & Building Limited | Construction | 2005 |
| Woodhouse Farm Landscapes Ltd | Agriculture & fishing | 2006 |
| Woodlands Garage (ST Helens) Limited | Wholesale & retail | 2013 |
| Woodlands Manor Limited | Health & social care | 2005 |
| Woolton Developments Limited | Real estate | 2001 |
| Wright & Beyer Limited | Energy | 1938 |
| Wynne Medical Services Limited | Health & social care | 2013 |
| Y.E.P.S. Limited | Professional & scientific | 2008 |
| Yeowynn Limited | Real estate | 2003 |
| YM Medical Services Limited | Health & social care | 2015 |
| Ymca ST Helens | Hospitality | 1985 |
| YOG Health Care Limited | Health & social care | 2018 |
| York and Young Limited | Wholesale & retail | 2000 |
| Young Persons Advisory Service | Health & social care | 1991 |
| Zafar Medical and Surgical Services Limited | Health & social care | 2010 |
| Zeffa Music Limited | Arts & recreation | 2020 |