| Richmond Farms Limited | Hospitality | 1999 |
| Richmond Hill Kennels Ltd | Other services | 2003 |
| Ringtail Holdings Limited | Wholesale & retail | 2002 |
| Rmxdirect Limited | Wholesale & retail | 2003 |
| Roadcraft (Crane & Plant Hire) Limited | Administrative & support | 1981 |
| Roberts Medical Services Limited | Construction | 2018 |
| Robinson Estimating and Costing Services Ltd | Mining & quarrying | 2007 |
| Roger Baron IFA Limited | Financial services | 2007 |
| Roll & Stop Photography Shop Ltd | Other services | 2020 |
| Roof Blind Services Limited | Manufacturing | 2007 |
| Roofscape Northwest Ltd. | Construction | 1997 |
| Rope Resource Ltd | Administrative & support | 2015 |
| Rotunda Enterprises C.I.C. | Administrative & support | 2004 |
| Route 3 (Network Solutions) Ltd | Professional & scientific | 2005 |
| Route 3 Limited | Information & communication | 2002 |
| Rowson Street Management Limited | Households | 1992 |
| Royal Court Liverpool Trust Limited | Arts & recreation | 2006 |
| RSD Hygienics Limited | Construction | 2003 |
| Runt Films Ltd | Information & communication | 2023 |
| Russ Kenrick Associates Limited | Professional & scientific | 2004 |
| Russell Dean Limited | Extraterritorial | 2005 |
| Russell Holding Estates Limited | Real estate | 2025 |
| S & S Motors (St.Helens) Limited | Wholesale & retail | 2001 |
| S Azim Holdings Limited | Financial services | 2023 |
| S. B. Carr Limited | Administrative & support | 2000 |
| S. J. Mitchell Limited | Construction | 2002 |
| S.S. Milton Limited | Wholesale & retail | 1978 |
| Saba Newsagent Ltd | Wholesale & retail | 2007 |
| Safety Wellbeing and Challenging Abuse Ltd. | Administrative & support | 1997 |
| Safetyworks Training Limited | Professional & scientific | 2024 |
| Saint Helens Bowling Club Limited | Arts & recreation | 1880 |
| SAMS23 Ltd | Administrative & support | 2023 |
| Sancar Enterprise Yorkshire Limited | Wholesale & retail | 2017 |
| Sartorius Civil Engineering Limited | | 2000 |
| Satishkar Limited | Health & social care | 2025 |
| Sats Wellbeing Ltd | Education | 2023 |
| SB Haulage (UK) Ltd | Transport & logistics | 2006 |
| SC Solar (North West) Ltd | Manufacturing | 2026 |
| Scent Trail Limited | Other services | 2005 |
| Schumann & Associates Limited | Professional & scientific | 2017 |
| Scirroco Limited | Professional & scientific | 2007 |
| Screenvale Limited | Construction | 1997 |
| Scribble Pictures Limited | Information & communication | 2023 |
| Sea Air Land Systems Ltd | Professional & scientific | 2013 |
| Seabank Estates Ltd | Construction | 2007 |
| Searidge Holdings Limited | Real estate | 1967 |
| Sefton Acupuncture Clinic Limited | Health & social care | 2004 |
| Sefton Glass Limited | Construction | 2006 |
| Sefton Park Palm House Preservation Trust | Arts & recreation | 1996 |
| Sefton View Management Association Limited | Real estate | 1978 |
| Seqirus Vaccines Limited | Manufacturing | 2000 |
| Sharples Transport,Limited | Transport & logistics | 1945 |
| Shepherd Developments (Wirral) Limited | Construction | 1985 |
| Sherwood Building & Maintenance Ltd | Construction | 1999 |
| SHH 501 Limited | Administrative & support | 2013 |
| Shieldbridge Management Company Limited | Households | 1978 |
| Shinav Ltd | Health & social care | 2012 |
| Shrewsbury Diocese Commercial Co Limited | Hospitality | 1993 |
| SHS International Ltd | Manufacturing | 1910 |
| Silcock Holdings Limited | Administrative & support | 2005 |
| Silcock Leisure (North West) Limited | Hospitality | 2005 |
| Simms Builders Limited | Construction | 2003 |
| Simon Barnes Carpets Limited | Wholesale & retail | 1987 |
| Simonswood Properties Limited | Real estate | 2003 |
| Simonvale Limited | | 1989 |
| Simpson Consultancy Ltd | Professional & scientific | 2004 |
| Simpson Estates Limited | Construction | 2004 |
| SJ Carpets Limited | Wholesale & retail | 2005 |
| Sky Drinks Group Ltd | Manufacturing | 2025 |
| Sloxi Studios Limited | Information & communication | 2025 |
| Small Print Compare Limited | Professional & scientific | 2024 |
| SMF Energy Limited | Construction | 2016 |
| Smith Decorating Ltd | Construction | 2007 |
| Smyth and Associates Ltd | Professional & scientific | 2009 |
| Somali Womens Group | Administrative & support | 2005 |
| Sophiajiadaderetail Limited | Wholesale & retail | 2025 |
| South Liverpool Vineyard Christian Fellowship | Other services | 1996 |
| Southport Blinds Limited | Wholesale & retail | 2019 |
| Southport Carriage Company Ltd | Other services | 2007 |
| Southport Disco Festival Limited | Hospitality | 2021 |
| Southport Visionplus Limited | Wholesale & retail | 1991 |
| Southport Watersports Limited | Arts & recreation | 2001 |
| Specialbuild Limited | Wholesale & retail | 1999 |
| Speedy Engineering Services Limited | Administrative & support | 2007 |
| Speedy Hire (UK) Limited | Administrative & support | 1930 |
| Speedy Hire Centres (Midlands) Limited | Administrative & support | 1972 |
| Speedy Hire Centres Limited | Administrative & support | 2007 |
| Speedy Industrial Services Limited | Administrative & support | 1973 |
| Speedy Lifting Limited | Administrative & support | 2002 |
| Speedy Plant Hire Ltd. | Administrative & support | 1986 |
| Speedy Power Limited | Administrative & support | 2000 |
| Speedy Rail Services Limited | Administrative & support | 2000 |
| Speedy Space Ltd. | Administrative & support | 1974 |
| Speedy Support Services Limited | Administrative & support | 1990 |
| Speedy Survey Limited | Administrative & support | 1999 |
| Speedy Transport Limited | Administrative & support | 2002 |
| Speedyloo Limited | Professional & scientific | 1996 |
| Spencer & Gilbert Limited | Wholesale & retail | 2003 |
| Splendid Things | Arts & recreation | 2005 |
| Spphpt Trading Company Limited | Arts & recreation | 1999 |