| Riverside Cladding Ltd | Construction | 2025 |
| Riverside Matlock Limited | Construction | 2025 |
| Riverview Leisure Properties Limited | Real estate | 2021 |
| Riverview Leisure Vehicles Limited | Professional & scientific | 2013 |
| RJH & Sons Ltd | Manufacturing | 2018 |
| Rjrl Limited | Professional & scientific | 2018 |
| RJT Entertainments Limited | Hospitality | 2004 |
| Rnorth Consulting Ltd | Professional & scientific | 2024 |
| Road Graffiti Limited | Arts & recreation | 2003 |
| ROB Woods Art Limited | Arts & recreation | 2023 |
| Robert Young Florists Ltd | Wholesale & retail | 2003 |
| Robert's Wine Bar Ltd | Wholesale & retail | 2025 |
| Robinson & Day Properties Limited | Real estate | 2023 |
| Robinson Investment & Consultancy Ltd | Professional & scientific | 2015 |
| Robinsons Longcliffe Limited | Construction | 1996 |
| Rocca Services Limited | Administrative & support | 2022 |
| Rock Mill Apartments Ltd | Hospitality | 2023 |
| Rocket Signs and Graphics Ltd | Manufacturing | 2024 |
| Rockwave Consulting Ltd | Information & communication | 2008 |
| Roes Court Management Company Limited | Households | 2004 |
| Roeway Transport Ltd | Transport & logistics | 2020 |
| Roger Lambert (Transport) Limited | Transport & logistics | 1989 |
| Roger Yarwood Planning Consultant Limited | Professional & scientific | 2009 |
| Rogers Cory Partnership Limited | Construction | 2007 |
| Romake Limited | Construction | 1979 |
| Ron's Rope Access Limited | Manufacturing | 2026 |
| Ropemasters Ltd | Construction | 2024 |
| Rose Thorn Limited | Real estate | 2026 |
| Rotosteel Limited | Manufacturing | 2019 |
| Rouse Properties Limited | Construction | 2010 |
| Rowan Renewable Energy Ltd | Energy | 2019 |
| Rowandale of Wirksworth Limited | Manufacturing | 2004 |
| Rowes Gardens & Home Improvements Ltd | Other services | 2021 |
| Rowsley Ltd | Professional & scientific | 2026 |
| RSP Hospitality Ltd | Hospitality | 2023 |
| RUBBISH24-7 Ltd | Water & waste | 2025 |
| Rubigo Ltd | Hospitality | 2017 |
| Run Forest Run Shop Limited | Wholesale & retail | 2026 |
| Runkerry Consulting Ltd | Professional & scientific | 2023 |
| Rupert Hairdressing Limited | Real estate | 1984 |
| Rural Accountants Ltd | Professional & scientific | 2019 |
| Rural Action Derbyshire | Health & social care | 1997 |
| RW Design Services Ltd. | Professional & scientific | 1997 |
| Ryder Point Wind Limited | Energy | 2014 |
| Ryder Security Systems Limited | Administrative & support | 2018 |
| S (F) K & SON Limited | Transport & logistics | 1997 |
| S Bown & Co. Limited | Construction | 2011 |
| S G N Selwood Electrical Contractors Limited | Construction | 2003 |
| S T Engineering Services Ltd | Professional & scientific | 2023 |
| S T Transport Ltd | Transport & logistics | 2008 |
| S&B Housing Ltd | Real estate | 2024 |
| S&Jb Services Ltd | Other services | 2024 |
| S.Donegan Engineering & Fabrication Ltd | Manufacturing | 2025 |
| S1 Gallery Collective CIC | Wholesale & retail | 2024 |
| Sabine HAY Events Limited | Arts & recreation | 2024 |
| Safehands Ltd | Construction | 2016 |
| Safety Critical Training Solutions UK Limited | Wholesale & retail | 2017 |
| Safewire Electrical Limited | Manufacturing | 2001 |
| SAL IP Holdco Limited | Professional & scientific | 2026 |
| Salvat Group Limited | Professional & scientific | 2023 |
| Salvus Blast Limited | Professional & scientific | 2014 |
| SAM Furniss Limited | Wholesale & retail | 1999 |
| SAM Shrimpton Brewing Ltd | Manufacturing | 2023 |
| Sanderson Imobiliare Limited | Financial services | 2022 |
| Sandrine Augey's Piano School Ltd | Education | 2010 |
| Sarah Afiovana Ltd. | Professional & scientific | 2017 |
| Sarah Southwell Limited | Professional & scientific | 2019 |
| Sargent Property Holdings Ltd | Real estate | 2024 |
| Sarsen Connect Limited | Education | 2020 |
| Sash Italia Limited | Professional & scientific | 2003 |
| Savage Fabrications Ltd | Manufacturing | 2024 |
| Scantlebury Properties Ltd | Real estate | 2026 |
| Scarborough BUS Depot Limited | Energy | 2025 |
| Scargill Limited | Other services | 1996 |
| Scout Outdoor Limited | Wholesale & retail | 2017 |
| Scrase Limited | Information & communication | 2013 |
| SD Painting Contractors Limited | Construction | 2012 |
| Seen the Light Ltd | Construction | 2011 |
| Sekali Design Limited | Professional & scientific | 2015 |
| SEND4CHANGE Ltd | Professional & scientific | 2015 |
| Seneca Consultancy Limited | Professional & scientific | 2015 |
| Seneca IP (Manchester) Limited | Professional & scientific | 2025 |
| Seneca IP Limited | Professional & scientific | 2006 |
| Senile Squirrel Studio Ltd | Hospitality | 2023 |
| Senses...Skin Care Centre Limited | Other services | 2009 |
| Seth Punchard Commercial Services Ltd | Wholesale & retail | 2021 |
| Seth Punchard Ltd | Transport & logistics | 2026 |
| Shaledrift Limited | Administrative & support | 2002 |
| Shepburn Ltd | Professional & scientific | 2015 |
| Shepperton Builders Limited | Construction | 1952 |
| Shepperton Group Limited | Professional & scientific | 1977 |
| Shyre Ltd | Manufacturing | 2012 |
| Siddall Security Systems Ltd | Administrative & support | 2026 |
| Sign Sense App Ltd | Professional & scientific | 2024 |
| Silverlining Finance Ltd | Professional & scientific | 2012 |
| Simap Technical Services Ltd | Information & communication | 2010 |
| Simclair Ltd | Hospitality | 2019 |
| Simon Bolton Limited | Professional & scientific | 2023 |
| Simply Changing Limited | Health & social care | 2008 |
| Simply Steam Ltd | Manufacturing | 2024 |