| Somerville House Management Company Limited | Real estate | 1989 |
| Soul Emporium Ltd | Wholesale & retail | 2021 |
| Soul Food Cafe Limited | Hospitality | 2023 |
| Soulwork Strategies Ltd | Professional & scientific | 2025 |
| Sounds at Speed Limited | Professional & scientific | 2007 |
| Soundtrack House Ltd | Information & communication | 2020 |
| South East Nutrition Ltd | Health & social care | 2024 |
| South East Recovery & Car Solutions Ltd | Wholesale & retail | 2023 |
| South East Structures Limited | Construction | 2019 |
| South East Talent Ltd | Health & social care | 2025 |
| South Eastern Tavern Limited | Hospitality | 2016 |
| South Kent Cleaning Limited | Administrative & support | 2022 |
| Southeast Sprinkler & Dryriser Ltd | Construction | 2019 |
| Sovereign Responsibility | Information & communication | 2025 |
| Sowena Holdings Ltd | Real estate | 2026 |
| Sowena Lettings Ltd | Real estate | 2021 |
| Sowena Property Ltd | Real estate | 2018 |
| Spark a Light Electrical Solutions Ltd | Construction | 2020 |
| Sparkboom Productions Ltd | Information & communication | 2024 |
| Sparkedge Innovations Ltd | Professional & scientific | 2024 |
| Sparkles Care Ltd | Health & social care | 2023 |
| Speak UP CIC | Health & social care | 2011 |
| SPEAK2PROFIT Ltd | Education | 2022 |
| Speaking of Learning Limited | Education | 2007 |
| Spearman Motorcycles Ltd | Wholesale & retail | 2025 |
| Spec Developments Limited | Construction | 2010 |
| Specialist Damp Solutions Ltd | Construction | 2021 |
| Specialist Painting Ltd | Construction | 2019 |
| Spicy Sasquatch Ltd | Real estate | 2021 |
| Spitfire Creative Technologies Limited | Financial services | 2018 |
| Sport Links Travel Ltd. | Administrative & support | 2013 |
| Sports Deal Limited | Wholesale & retail | 2006 |
| Sports IQ Ltd. | Arts & recreation | 2018 |
| Sportsfront Ltd | Wholesale & retail | 2011 |
| Spridon Ltd | Transport & logistics | 2023 |
| Spriing.Io Ltd | Information & communication | 2024 |
| SQ2 Construction Ltd | Construction | 2025 |
| Square Pizza Limited | Hospitality | 2023 |
| SR East Kent Ltd | Health & social care | 2019 |
| SRI Krishna Traders Limited | Wholesale & retail | 2024 |
| SRM Earwax Removal Ltd | Health & social care | 2026 |
| SRM Real Estates Ltd | Real estate | 2021 |
| SRN Convenience Store Ltd | Wholesale & retail | 2024 |
| SRP Renovations Limited | Construction | 2017 |
| SS Doctors Ltd | Health & social care | 2015 |
| SS Doctors Urology Ltd | Health & social care | 2025 |
| SS Residential & Commercial Properties Ltd | Real estate | 2020 |
| Ssnf Properties Ltd | Real estate | 2021 |
| ST Augustine’S Community Hub CIC | Health & social care | 2026 |
| ST Homes Ltd | Real estate | 2016 |
| ST John’S Collective Ltd | Construction | 2026 |
| ST Peters Scaffolding Services Ltd | Construction | 2015 |
| ST. Georges Garage Limited | Wholesale & retail | 2009 |
| ST. Lawrence House Ltd | Information & communication | 2025 |
| Stables Yard Margate Ltd | Construction | 2024 |
| Stack'D Margate Limited | Hospitality | 2025 |
| Stacy's School of Swimming Ltd | Education | 2021 |
| Stagg Distribution Limited | Wholesale & retail | 2022 |
| Stans Developments Ltd | Real estate | 2026 |
| Stars DIE Limited | Wholesale & retail | 2023 |
| Starsky Limited | Hospitality | 2013 |
| Start AS YOU Mean to Go on Records Ltd | Information & communication | 2026 |
| Steampunk Beaver Ltd | Professional & scientific | 2025 |
| Stella London Limited | Construction | 2020 |
| Step Mortgages Limited | Financial services | 2014 |
| STEP4WARD Services (Kent) Limited | Health & social care | 2019 |
| Stepney Property Services Limited | Real estate | 2003 |
| Sterling Group Management Limited | Hospitality | 2026 |
| Steven Marsden Design Limited | Professional & scientific | 2018 |
| Stevens Children's Homes Limited | Health & social care | 2024 |
| Stewart Beckett LLP | | 2011 |
| Stewart's Cafe Ltd | Hospitality | 2016 |
| Stickandseal Ltd | Manufacturing | 2026 |
| Stiki Properties Ltd | Real estate | 2018 |
| Stirling Hair Ltd | Other services | 2016 |
| Stirling Studios Limited | Information & communication | 2015 |
| Stone Space Sustara Ltd | Wholesale & retail | 2025 |
| Straight Line Consultancy Ltd | Administrative & support | 2022 |
| Strata Civic Ltd | Construction | 2025 |
| Stratton Avata Ltd | Energy | 2023 |
| Struthers and Sisters Ltd | Manufacturing | 2018 |
| Stuart Rosser Track Limited | Construction | 2019 |
| Student Matched Betting Limited | Information & communication | 2017 |
| Studio Farmer Limited | Professional & scientific | 2021 |
| Studio HE (S /HE) Ltd | Professional & scientific | 2016 |
| Studio Milkwood Ltd | Manufacturing | 2015 |
| Studio Mond Limited | Professional & scientific | 2019 |
| Studio Nice Nice Limited | Professional & scientific | 2022 |
| Studio Njoku Ltd | Wholesale & retail | 2024 |
| Studio Table Ltd | Professional & scientific | 2020 |
| Studio Thomas Limited | Professional & scientific | 2024 |
| Studio Were Ltd | Professional & scientific | 2024 |
| Style Machine Illustration Limited | Professional & scientific | 2010 |
| SUB Rosa Margate Ltd | Manufacturing | 2023 |
| Sub-Sea Power Ltd | Construction | 2020 |
| Subcontractme Ltd | Construction | 2015 |
| Sumair Enterprises Ltd | Manufacturing | 2026 |
| Summer Camp Holdings Ltd | Financial services | 2025 |
| Summer Camp Music Limited | Other services | 2011 |
| Sunley (Northdown) Residents Association Limited | Households | 1981 |