| SOS Waypoint Limited | Construction | 1996 |
| Soulstar (UK) Ltd | Wholesale & retail | 2018 |
| Soulstar Imports Ltd | Wholesale & retail | 2018 |
| Soulstar International Ltd | Wholesale & retail | 2017 |
| Soundvibe.Io Ltd | Information & communication | 2025 |
| Source (EC) Limited | Manufacturing | 1991 |
| Source a Factory Ltd | Wholesale & retail | 2025 |
| South West Properties Limited | Real estate | 2017 |
| Southwell Electrical Services Ltd | Construction | 2020 |
| Southwell PO Limited | Wholesale & retail | 2022 |
| Sovereign Plumbing & Heating Limited | Construction | 2023 |
| Soybos African Shop Limited | Wholesale & retail | 2024 |
| SP JSS Ltd | Real estate | 2026 |
| SP Services (Fabrications) 2007 Limited | Construction | 2007 |
| Spa Security & Events Limited | Public administration | 2008 |
| Sparklean Limited | Administrative & support | 2025 |
| Sparkly Home Solutions Limited | Administrative & support | 2025 |
| Sparks & Spanner’S Ltd | Wholesale & retail | 2026 |
| Specialised Engineering Design Ltd | Professional & scientific | 2011 |
| Specialist Neurodiversity Assessments Ltd | Public administration | 2025 |
| Specialist Supported Living Ltd | Other services | 2016 |
| Specrite Ltd | Professional & scientific | 2018 |
| Spectrum Engineering Limited | Mining & quarrying | 2003 |
| Spectrum Franchising Limited | Administrative & support | 1987 |
| Spectrum Life Hub Community Interest Company | Administrative & support | 2026 |
| Spectrum Mansfield Ltd | Financial services | 2021 |
| Speedy MAX Limited | Transport & logistics | 2020 |
| Spen Orridge Plumbing & Heating Limited | Construction | 2017 |
| Spencer Commercial Management (Lettings) Ltd | Real estate | 2019 |
| Spice Space Ltd | Hospitality | 2025 |
| Spider Operators (UK) Ltd | Administrative & support | 2025 |
| Spinel Horizon Ltd | Real estate | 2026 |
| Spinning Wheel Classic Cars Limited | Wholesale & retail | 2004 |
| Spinning Around Records Limited | Wholesale & retail | 2025 |
| Spire Asset Funding Limited | Financial services | 2014 |
| Spire Autoclave Services Ltd | Professional & scientific | 2019 |
| Spire Finance Solutions Limited | Extraterritorial | 2020 |
| Spiritsports.Inc Ltd | Wholesale & retail | 2024 |
| Splashdown Ltd | Administrative & support | 2017 |
| Splashtacular Swim School Limited | Education | 2020 |
| Sport 4 Kidz Ltd | Education | 2026 |
| Sporting Guns Ltd | Arts & recreation | 2025 |
| Sports Direct Holdings Limited | Financial services | 2008 |
| Sports Performance Insights Ltd | Information & communication | 2019 |
| Sports-Social Ltd | Professional & scientific | 2025 |
| Spox Collective Ltd | Wholesale & retail | 2025 |
| Spox Ltd | Wholesale & retail | 2021 |
| Spraycon Limited | Administrative & support | 1999 |
| Springfield Bookkeeping Services Limited | Professional & scientific | 2016 |
| Springvale Gardens Maintenance Company Limited | Households | 2021 |
| Sprite Creative Limited | Information & communication | 2013 |
| Spudit Ltd | Information & communication | 2019 |
| Spvaks Limited | Real estate | 2019 |
| Sqoshis Ltd | Health & social care | 2015 |
| SQS Properties Ltd | Real estate | 2024 |
| SR CNC Services Ltd | Manufacturing | 2022 |
| SR Passive Fire Limited | Construction | 2020 |
| Sridivya Stores Limited | Wholesale & retail | 2022 |
| SRK Construction Limited | Construction | 2019 |
| SRL Convenience Store Limited | Wholesale & retail | 2019 |
| SRL Crofts Property Ltd | Real estate | 2021 |
| SS Subs Ltd | Hospitality | 2022 |
| SSD Trans Ltd | Transport & logistics | 2021 |
| SSJ Ford Holdings Limited | Financial services | 2019 |
| SSL Digital Consulting Ltd | Information & communication | 2025 |
| SSS Competence, Wellbeing & Skills CIC | Education | 2025 |
| SSS Compliance Services Ltd | Information & communication | 2024 |
| SSS Training Academy Ltd | Public administration | 2024 |
| Sssj Ltd | Wholesale & retail | 2026 |
| SSW Property Management Ltd | Real estate | 2022 |
| ST Battery Services Limited | Professional & scientific | 2015 |
| ST George’S Childcare Services Limited | Health & social care | 2024 |
| ST Kitts Ltd | Wholesale & retail | 2026 |
| Staff Access Recruitment Limited | Administrative & support | 2019 |
| Staffridge Limited | Construction | 2024 |
| Stag Painting and Decorating Ltd | Construction | 2023 |
| Stag Shopfronts Limited | Construction | 2005 |
| Stags Tyres Limited | Wholesale & retail | 2019 |
| Staindrop Road Management Limited | Households | 2015 |
| Stainless Steel Equipment Limited | Manufacturing | 2022 |
| Stan Care Ltd | Health & social care | 2026 |
| Stan Line Trans Ltd | Transport & logistics | 2022 |
| Standard Enterprise Properties Limited | Real estate | 2003 |
| Stanley Road Management Limited | Households | 2013 |
| Star Barbers (Midlands) Ltd | Other services | 2023 |
| Star Garage Mansfield Ltd | Wholesale & retail | 2025 |
| Star Welding Mansfield Ltd | Manufacturing | 2026 |
| Starr Coaching Limited | Professional & scientific | 1995 |
| Startech Computing Limited | Professional & scientific | 2012 |
| Starz 21 Bar Ltd | Hospitality | 2025 |
| Starz Movement & Circus Arts CIC | Arts & recreation | 2015 |
| Statham Scanning Ltd | Health & social care | 2015 |
| Staticpast Ltd | Information & communication | 2025 |
| Statii Limited | Information & communication | 2010 |
| Station Road 1976 Limited | Extraterritorial | 2014 |
| Staton & Cushley Estate Agents Limited | Real estate | 2021 |
| Staton Mortgage & Protection Specialists Limited | Financial services | 2018 |
| Steamforce Ltd | Manufacturing | 2023 |
| Steampunk Events Ltd | Arts & recreation | 2025 |
| Steel City Wheels Limited | Manufacturing | 2024 |