| Sally Twinkle Limited | Wholesale & retail | 2026 |
| Salon Luxe Ltd | Other services | 2020 |
| Salt & Light Events Ltd | Arts & recreation | 2022 |
| Salty Towers Ltd | Hospitality | 2019 |
| SAM Sparks Photography Limited | Professional & scientific | 2026 |
| Samante Analytics Limited | Administrative & support | 2016 |
| Samarraaj Limited | Real estate | 2024 |
| Samfag Consultancy Ltd | Professional & scientific | 2012 |
| Samfag Event Ltd | Arts & recreation | 2024 |
| Sammy Service Ltd | Wholesale & retail | 2020 |
| Samo-Samo Wellbeing Ltd | Health & social care | 2019 |
| Samra Group Limited | Real estate | 2021 |
| Samra Investments UK Limited | Real estate | 2011 |
| Samuelson Consulting Limited | Construction | 2003 |
| Sandridgestar Ltd | Wholesale & retail | 2024 |
| Sandstone Group Ltd | Administrative & support | 2016 |
| Sanger Acquisitions Limited | Real estate | 2026 |
| Sanj Traders Ltd | Wholesale & retail | 2024 |
| Santranslate Limited | Professional & scientific | 2001 |
| SAQ Investments Limited | Real estate | 2025 |
| Sarach Properties Ltd | Real estate | 2011 |
| Sarah Hotels Ltd | Hospitality | 2023 |
| Sarah L Taylor Ltd | Professional & scientific | 2019 |
| Sargent Plumbing & Heating Ltd | Construction | 2023 |
| Sarjs News and Booze Limited | Wholesale & retail | 2014 |
| Sarona Cleaning Services Ltd | Administrative & support | 2024 |
| Sasco Holdings Limited | Financial services | 2026 |
| Sasi Development Ltd | Construction | 2026 |
| Sasin Ltd | Transport & logistics | 2017 |
| Saunders Electrical Engineering Ltd | Professional & scientific | 2025 |
| Savage Services UK Ltd | Administrative & support | 2019 |
| Savanna Re-Cycling Limited | Other services | 2015 |
| Savannah Trading International Limited | Real estate | 1995 |
| Savv-E Limited | Wholesale & retail | 2021 |
| Sayless Flexmore Ltd | Wholesale & retail | 2025 |
| SB Automation & Power Ltd | Construction | 2023 |
| Sbaj Properties Limited | Real estate | 2020 |
| SBK Services Ltd | Professional & scientific | 2016 |
| SBP Property Services Limited | Real estate | 2015 |
| Scan Baby Ltd | Wholesale & retail | 2019 |
| Scarecrow Farm Forest School C.I.C. | Education | 2024 |
| Scargill Mann (Burton) Ltd | Real estate | 2006 |
| Scents by Shane Ltd | Manufacturing | 2024 |
| Schmidt Leisure Limited | Administrative & support | 2018 |
| Schofield Education Services Ltd | Education | 2019 |
| School Energy Efficiency CIC | Professional & scientific | 2014 |
| Schools Mutual Services Limited | Education | 2020 |
| SCJ Contractors Limited | Construction | 2014 |
| SCL 8 Properties Limited | Real estate | 2023 |
| Scope Joinery & Shopfitting Limited | Construction | 2008 |
| Scoresby Escape Whitby Ltd | Hospitality | 2016 |
| Scortex Solutions Limited | Professional & scientific | 2000 |
| Scott - Spencer Building Services Limited | Construction | 2021 |
| Scott Cameron Drylining Ltd | Construction | 2022 |
| Scott Development & Lettings Limited | Real estate | 2025 |
| Scott Your Back Limited | Administrative & support | 2022 |
| Sdcce Ltd | Education | 2026 |
| Sdhh Ltd | Wholesale & retail | 2026 |
| SDJ Electrical Ltd | Construction | 1999 |
| SDM Joinery Manufacturers Ltd | Construction | 2009 |
| Seaforth Rannoch Limited | Extraterritorial | 2001 |
| Seal Rock Enterprises Limited | Administrative & support | 2003 |
| Seals Commercial Support Ltd | Professional & scientific | 2026 |
| Seals King & Co. Limited | Professional & scientific | 2007 |
| Seals Properties Limited | Real estate | 2021 |
| Sean Palmer Auto Electrics Ltd | Manufacturing | 2025 |
| Searle Enterprises Limited | Construction | 2017 |
| Seasonstore Ltd | Wholesale & retail | 2019 |
| Seaview Fisheries Limited | Hospitality | 2009 |
| Seaview Investment Holdings Limited | Financial services | 2022 |
| Sebastian Dobra Ltd | Real estate | 2022 |
| Sebrof Nottingham Limited | Real estate | 2002 |
| Secret Marketing Coach Ltd | Professional & scientific | 2014 |
| Secrets of Sherwood Ltd | Wholesale & retail | 2020 |
| Secucloud Limited | Information & communication | 2025 |
| Securesmith Ltd | Administrative & support | 2023 |
| Securetec Systems Limited | Construction | 2019 |
| Securify Limited | Information & communication | 2018 |
| Seddon Property Group Limited | Real estate | 2025 |
| SEE Tech Limited | Construction | 1991 |
| Sefton’S Gardening Ltd | Extraterritorial | 2020 |
| Seismik Ltd | Information & communication | 2008 |
| Select Bloodstock Limited | Arts & recreation | 2008 |
| Selenni UK Ltd | Manufacturing | 2021 |
| Sell Happy Ltd | Real estate | 2025 |
| Selling Your Caravan Ltd | Wholesale & retail | 2024 |
| Semiconductor Investments Ltd | Wholesale & retail | 2020 |
| Sena Pizza Ltd | Hospitality | 2019 |
| Sense Lockers Limited | Arts & recreation | 2017 |
| SEOCIAL9 Ltd | Professional & scientific | 2021 |
| Serafina Property Limited | Real estate | 2019 |
| Seren Solutions (Training) Ltd | Education | 2019 |
| Serendipity (London) Ltd. | Manufacturing | 1995 |
| Serenity Aesthetics and Laser Clinic Ltd | Other services | 2014 |
| Serenity Counselling Practice Ltd | Health & social care | 2021 |
| Serenity Engineering Ltd | Professional & scientific | 2022 |
| Serentia Ltd | Professional & scientific | 2021 |
| Serosensa Limited | Professional & scientific | 2012 |
| Serverman Limited | Information & communication | 2013 |
| Services Lubrication Limited | Other services | 1996 |