| Designer Bedrooms & Kitchens Ltd | Construction | 2003 |
| Designer Bites Cakes Ltd | Hospitality | 2025 |
| Designer Brands Ltd | Wholesale & retail | 2025 |
| Designer Clothing (MCR) Ltd | Wholesale & retail | 2022 |
| Designer Doors Direct Ltd | Manufacturing | 2021 |
| Designer Fabrics Ltd | Wholesale & retail | 2020 |
| Designer Media Limited | Professional & scientific | 2009 |
| Designer Outlet Ltd | Wholesale & retail | 2025 |
| Designer Perfumes Ltd | Wholesale & retail | 2020 |
| Designer Style Limited | Wholesale & retail | 2025 |
| Designer TAN & Beauty Limited | Other services | 2004 |
| Designers Hair and Beauty Ltd | Other services | 2010 |
| Designlife App Limited | Professional & scientific | 2014 |
| Designprintcentre Limited | Manufacturing | 2017 |
| Designs and Patterns Ltd | Wholesale & retail | 2025 |
| Designs for YOU (UK) Ltd | Professional & scientific | 2013 |
| DESIGNS4U Ltd | Construction | 2018 |
| Designworks (Cheshire) Limited | Wholesale & retail | 2007 |
| Designx Ltd | Professional & scientific | 2025 |
| Desil Limited | Wholesale & retail | 2018 |
| Desination CIC | Information & communication | 2025 |
| Desipride Records Limited | Other services | 2017 |
| Desire Clothing Limited | Wholesale & retail | 2002 |
| Desire Fashion Ltd | Manufacturing | 2023 |
| Desired V Decor Ltd | Construction | 2023 |
| Desiscoop Limited | Hospitality | 2025 |
| Desk 123 Ltd | Administrative & support | 2024 |
| Desk Cush Ltd | Wholesale & retail | 2024 |
| Deskmate Software Ltd | Information & communication | 2024 |
| Desktop Projects Limited | Wholesale & retail | 1991 |
| Deslo Ltd | Wholesale & retail | 2021 |
| Desman Services Ltd | Health & social care | 2019 |
| Desmond Training Limited | Education | 2005 |
| Desperano for Trading Ltd | Wholesale & retail | 2026 |
| Desser and Company Limited | Wholesale & retail | 1923 |
| Desser Associates Ltd | Information & communication | 2023 |
| Dessert and Cafes Ltd | Hospitality | 2025 |
| Dessert Co Wigan Ltd | Hospitality | 2026 |
| Dessert Delights Limited | Hospitality | 2021 |
| Dessert District Limited | Hospitality | 2025 |
| Dessert House on the River Limited | Hospitality | 2016 |
| Dessert Infinity Ltd | Wholesale & retail | 2023 |
| Dessert Station 1 Ltd | Hospitality | 2025 |
| Dessert Therapy Ltd | Manufacturing | 2024 |
| Desserted Limited | Wholesale & retail | 2024 |
| Desserts Delivered Durham Ltd | Hospitality | 2018 |
| Desserts Runcorn Ltd | Hospitality | 2024 |
| DESSERTS313 Limited | Hospitality | 2026 |
| Desta Consulting Limited | Information & communication | 2016 |
| Desta's Restaurants LLP | | 2024 |
| Destination Beauty NW Ltd | Other services | 2018 |
| Destination Dining Ltd | Financial services | 2021 |
| Destination Manchester Limited | Professional & scientific | 2005 |
| Destination Sport Limited | Administrative & support | 2015 |
| Destiney Social Care Provider Ltd | Health & social care | 2018 |
| Destiny Brokers Group Limited | Administrative & support | 2021 |
| Destiny Care Group Ltd. | Health & social care | 2017 |
| Destiny Desserts Ltd | Hospitality | 2023 |
| Destiny Music Records Limited | Arts & recreation | 2019 |
| Destiny Travel Ltd | Administrative & support | 2025 |
| Desvelado Beauty Limited | Wholesale & retail | 2025 |
| Deswal Investment Group Limited | Financial services | 2020 |
| Detail 2 Recruitment Ltd | Administrative & support | 2007 |
| Detail Content Limited | Information & communication | 2019 |
| Detail Marketing Limited | Professional & scientific | 2018 |
| Detail Therapy Ltd | Administrative & support | 2026 |
| Detailed Services Limited | Manufacturing | 2002 |
| Detailing Bros Ltd | Wholesale & retail | 2025 |
| Details Events Limited | Other services | 2023 |
| Detergent Information Limited | Extraterritorial | 1978 |
| Detock Global Limited | Wholesale & retail | 2020 |
| Detoolz Int'L Trade Co., Ltd | Wholesale & retail | 2022 |
| Detrafford Living Ltd | Real estate | 2016 |
| Detrafford NO1 Castlefield Ltd | Administrative & support | 2016 |
| Detroit Dough Boys Ltd | Hospitality | 2026 |
| Detroit Slims Ltd | Hospitality | 2024 |
| Deuce Associates Ltd | Administrative & support | 2023 |
| Deuce Padel Club Limited | Arts & recreation | 2025 |
| Deucon Ltd | Administrative & support | 2018 |
| Deuonters Limited | Information & communication | 2024 |
| Deurali Restaurant Ltd | Hospitality | 2022 |
| Deus Vult Empire Limited | Administrative & support | 2023 |
| Deutsch Centre International Limited | Education | 2020 |
| Deutsch Performance Limited | Wholesale & retail | 2016 |
| Deutsche Neubau AG Ltd | Construction | 2026 |
| Deutsche Speed Limited | Wholesale & retail | 2021 |
| Deuvick Int’L Limited | Real estate | 2020 |
| Deuvick Limited | Hospitality | 2020 |
| Deux Lumière Ltd | Wholesale & retail | 2025 |
| Deux SIX Wines Ltd | Wholesale & retail | 2025 |
| DEV Ring Limited | Information & communication | 2024 |
| DEV Yeti Solutions Ltd | Information & communication | 2024 |
| Dev-O IT Solutions Limited | Information & communication | 2016 |
| DEV2 Limited | Construction | 2021 |
| Deva Heights (Chester) Management Company Limited | Households | 1998 |
| Devan Property Ltd | Real estate | 2019 |
| Devangst Enterprises Limited | Information & communication | 2016 |
| Devano Ltd | Wholesale & retail | 2022 |
| Devan’S Fade Limited | Other services | 2024 |
| Devaughn Logistics Ltd | Transport & logistics | 2022 |