| DUM DUM Franchising Limited | Hospitality | 2015 |
| DUM DUM Retail Limited | Hospitality | 2013 |
| Dumisani Healthcare Limited | Health & social care | 2008 |
| Dunlop Business Solutions Ltd | Professional & scientific | 2018 |
| Durban Payroll Services Ltd | Administrative & support | 2025 |
| Durdygozel Davies Ltd | Extraterritorial | 2024 |
| Durgan Monstein Ltd | Professional & scientific | 2001 |
| Durris Wind Farm Limited | Energy | 2021 |
| Durweston Hydro Limited | Energy | 2015 |
| DVS Home Private Ltd | Real estate | 2023 |
| DW Performance Ltd | Professional & scientific | 2025 |
| DW Surface Repairs Ltd | Construction | 2015 |
| DWG Structures Limited | Professional & scientific | 2018 |
| Dwpf Services Limited | Financial services | 2017 |
| Dylan J Pickering Ltd | Wholesale & retail | 2024 |
| Dynalytical Synergies Limited | Information & communication | 2007 |
| Dynamic Protection Limited | Administrative & support | 2025 |
| Dynamic Workflow Solutions Limited | Administrative & support | 2011 |
| Dynamic Yacht Management Limited | Manufacturing | 2014 |
| Dynamics Works Ltd | Wholesale & retail | 2019 |
| Dynapp Limited | Information & communication | 2021 |
| Dynatrace Limited | Information & communication | 1980 |
| E & S Retail Limited | Professional & scientific | 1993 |
| E - Parking Worldwide Limited | Transport & logistics | 2025 |
| E Leondaki Limited | Health & social care | 2008 |
| E N Shone & Company Limited | Extraterritorial | 2017 |
| E S Electric LLP | | 2011 |
| E S Rowing Services Limited | Manufacturing | 2007 |
| E SUB Limited | Professional & scientific | 1991 |
| E&M Clairemont Ltd | Financial services | 2025 |
| E&R Gaming Solutions Ltd | Wholesale & retail | 2025 |
| E-Storage Investments Limited | Real estate | 2024 |
| E-Storage Worldwide Ltd | Transport & logistics | 2017 |
| E-Ventories Ltd | Administrative & support | 2017 |
| E.C.Jarnet Ltd | Real estate | 2022 |
| E.J. Mansbridge (Engineering) Limited | Manufacturing | 1974 |
| E.L.P. Electrical Services Limited | Construction | 2015 |
| E2CARBON Ltd | Construction | 2025 |
| E2I Limited | Extraterritorial | 1999 |
| Eagle Hall LLP | | 2005 |
| EAGLE365 Trades Ltd | Wholesale & retail | 2024 |
| Ealanta Systems Limited | Information & communication | 2011 |
| Early Rise Build & Landscape Limited | Administrative & support | 2022 |
| East Anglia & Wessex Care Homes Ltd | Health & social care | 2026 |
| East Participations Company Limited | Administrative & support | 2002 |
| Eastern & Wychwood Limited | Professional & scientific | 2014 |
| Eastern Retail Limited | Real estate | 2018 |
| Eastside Mbps Ltd | Financial services | 2018 |
| Eastwood Financial Solutions Ltd | Financial services | 2007 |
| Easy Number Plates Limited | Manufacturing | 2016 |
| Easy Teach Ltd | Education | 2018 |
| EASYLET365 Ltd | Financial services | 2015 |
| Eaton Socon Hydro Limited | Construction | 2013 |
| Eaton Square Capital Limited | Professional & scientific | 2012 |
| Eatwell (Maidenhead) Ltd | Hospitality | 2022 |
| Eatzo Ltd | Hospitality | 2026 |
| Ebaay - Online Ltd | Wholesale & retail | 2020 |
| Echelon Financial Partners Ltd | Professional & scientific | 2025 |
| Echo 419 Ltd | Hospitality | 2024 |
| Echo Design Limited | Construction | 2025 |
| ECL Consulting Limited | Professional & scientific | 2011 |
| Eclipse Design Services Ltd | Construction | 2007 |
| Eco Guard Solutions Ltd | Administrative & support | 2025 |
| Eco Improvement Homes Ltd | Construction | 2025 |
| Ecoally Homes Limited | Construction | 2016 |
| Ecoaly Limited | Administrative & support | 2014 |
| Ecofreaks Group Limited | Wholesale & retail | 2020 |
| Ecoleap Limited | Professional & scientific | 2011 |
| Ecom T Reach Ltd | Wholesale & retail | 2025 |
| Econestor Ltd | Professional & scientific | 2025 |
| Ecovit Limited | Wholesale & retail | 2001 |
| Ecreativ Limited | Professional & scientific | 2020 |
| Ecrin Barbers Limited | Other services | 2024 |
| Ecshan Limited | Wholesale & retail | 2023 |
| Eddyline Ventures Ltd | Professional & scientific | 2013 |
| EDE Property Accounting Ltd | Professional & scientific | 2025 |
| Edem Housing Solutions CIC | Health & social care | 2025 |
| Eden Projects Limited | Professional & scientific | 2003 |
| Eden Tours Limited | Administrative & support | 2014 |
| Edgewood Properties Limited | Real estate | 2021 |
| EDH Property Ltd | Real estate | 2025 |
| Edison Technology Limited | | 1987 |
| Editor's Quill Ltd | Manufacturing | 2024 |
| Editorial Advantage Limited | Professional & scientific | 2023 |
| Edums Ltd | Professional & scientific | 2024 |
| Edval Consultancy Limited | Health & social care | 2026 |
| Eebikes Ltd | Arts & recreation | 2020 |
| Eebz Limited | Information & communication | 2019 |
| EFF & KAY Ltd | Other services | 2024 |
| Effectengage Limited | Financial services | 1996 |
| Efficacy Group Ltd | Administrative & support | 2020 |
| Effort Ltd | Construction | 2025 |
| Egitronic Ukeig | | 1990 |
| EGO Pharmaceuticals (UK) Limited | Wholesale & retail | 2002 |
| EI Capital LLP | | 2010 |
| EIH Services Ltd | Professional & scientific | 2020 |
| EIM Holdings Limited | Transport & logistics | 2021 |
| Eits Frankton Limited | Other services | 2018 |
| EJB Consulting Ltd | Professional & scientific | 2009 |
| EJD Ventures Ltd | Real estate | 2024 |