| Stapeley Lodge Farm Limited | Agriculture & fishing | 2024 |
| Star Consultancy and Coaching Ltd | Professional & scientific | 2023 |
| Star Tennis Ltd | Education | 2015 |
| Stargazer Training Ltd | Manufacturing | 2009 |
| Starlitebay Ltd | Professional & scientific | 2009 |
| Startup Growth Ltd | Professional & scientific | 2024 |
| Statiflo Associates Limited | Financial services | 2025 |
| Statiflo Group Holdings Ltd | Financial services | 2019 |
| Statiflo International Limited | Manufacturing | 1993 |
| Statiflo Investments Limited | Financial services | 2021 |
| Stayri Developments Ltd | Real estate | 2025 |
| Stayri Group Ltd | Real estate | 2025 |
| Stayri Management Ltd | Real estate | 2025 |
| Staysis Limited | Manufacturing | 2010 |
| Steadfast Building Ltd | Construction | 2021 |
| Stealth BJJ Macclesfield Limited | Education | 2022 |
| Stealth Smart Technologies Limited | Wholesale & retail | 2021 |
| Steedrive Limited | | 1979 |
| Steel and Construction Services Ltd | Construction | 2022 |
| Steele Joinery Ltd | Construction | 2020 |
| Steezoworld Ltd | Wholesale & retail | 2026 |
| Stein Media Ltd | Information & communication | 2016 |
| Stellify Build Limited | Construction | 2020 |
| Stellify Building Projects Limited | Construction | 2019 |
| Stellify Marthall Limited | Construction | 2023 |
| Stellify Prestbury Limited | Construction | 2023 |
| Stelvio Inc Limited | Administrative & support | 2025 |
| Step Above the Rest Ltd | Manufacturing | 2011 |
| Stephen Froehlich Limited | Construction | 2020 |
| Stephen PYE Heating Ltd | Construction | 2007 |
| Stepiron Training Services Limited | Education | 2020 |
| Stepping Stones Building a New Direction Limited | Health & social care | 2019 |
| Still Point Creative Ltd | Information & communication | 2025 |
| Stitch Agency Ltd | Information & communication | 2026 |
| Stjc Ltd | Professional & scientific | 2023 |
| Stock Park Woodlands Limited | Agriculture & fishing | 2000 |
| Stockport 061 Motor Club Limited | Arts & recreation | 1961 |
| Stockport Food Equipment Limited | Manufacturing | 2003 |
| Stockport KBB Ltd | Wholesale & retail | 2018 |
| Stockport Self Storage Ltd | Real estate | 2024 |
| Stokers Arms Ltd | Hospitality | 2020 |
| Stokes Building and Plastering Ltd | Construction | 2023 |
| Stonyfold Farm Ltd | Agriculture & fishing | 2019 |
| Storie Studios Limited | Information & communication | 2025 |
| Stories and Stars Limited | Wholesale & retail | 2026 |
| Storm Brewing Company Ltd | Manufacturing | 2006 |
| Stormbringer Limited | Extraterritorial | 2013 |
| Stormgazer Consulting Ltd | Professional & scientific | 2017 |
| Story SO FAR Films Ltd | Information & communication | 2024 |
| STR Improvements Ltd | Administrative & support | 2023 |
| Strada FIX Limited | Construction | 2023 |
| Stratastem Limited | Professional & scientific | 2012 |
| Strategy Network Limited | Professional & scientific | 1995 |
| Stream BIO Ltd | Professional & scientific | 2015 |
| Streamline Sports Limited | Information & communication | 2024 |
| Stretch Tent Hire Ltd | Arts & recreation | 2024 |
| Strika Ltd | Wholesale & retail | 2024 |
| Strix Candles Ltd | Manufacturing | 2022 |
| Strtgy Socials Ltd | Professional & scientific | 2025 |
| Stssc Limited | Wholesale & retail | 2010 |
| Stu's Loo's Ltd | Administrative & support | 2024 |
| Stuart J Warrington & Co Limited | Real estate | 2018 |
| Stuart Morris Consulting Limited | Administrative & support | 2015 |
| Stuart Pond Design Limited | Professional & scientific | 2017 |
| Stuarts Homes Ltd | Households | 2019 |
| Stuarts Property Services Limited | Real estate | 2001 |
| Studio Etta Limited | Arts & recreation | 2025 |
| Studio Links Ltd | Arts & recreation | 2020 |
| Studio NO6 Ltd | Professional & scientific | 2025 |
| Studioino Ltd | Professional & scientific | 2025 |
| Sturloe Management Consultants Limited | Manufacturing | 2021 |
| Style Crowd Ltd | Wholesale & retail | 2020 |
| Stzy Products Ltd | Wholesale & retail | 2020 |
| Suade Labs Ltd | Information & communication | 2014 |
| Suboptimal Skate Shop Ltd | Wholesale & retail | 2022 |
| Substation Brixton Limited | Arts & recreation | 2021 |
| Substation Leisure Limited | Arts & recreation | 2019 |
| Substation Macclesfield Limited | Arts & recreation | 2017 |
| SUE J Ltd | Hospitality | 2017 |
| Sugarkane Music Limited | Arts & recreation | 2003 |
| Sumexigo Ltd | Extraterritorial | 2014 |
| Summit Special Limited | Hospitality | 2013 |
| Sunnyside Cottage Limited | Professional & scientific | 2004 |
| Sunrise Resources PLC | Mining & quarrying | 2005 |
| Sunset Beach Residents Association Limited | Real estate | 2014 |
| Super Drainage Solutions Ltd | Other services | 2025 |
| Super Solutions Limited | Information & communication | 2020 |
| Superbike Factory Group Limited | Financial services | 2023 |
| Superbike Factory Limited | Wholesale & retail | 2012 |
| Superbike Group Limited | Extraterritorial | 2015 |
| Superbike Insure Limited | Extraterritorial | 2015 |
| Superbike Loans Limited | Financial services | 2013 |
| Supply Chain Advice Network Limited | Professional & scientific | 2022 |
| Support Concepts Ltd | Health & social care | 2010 |
| Support My Raise Limited | Professional & scientific | 2024 |
| Sure Consultancy Ltd | Professional & scientific | 2022 |
| Sure Control UK Limited | Extraterritorial | 2015 |
| Surgionix Limited | Manufacturing | 2012 |
| Sustainable Computing Solutions Ltd | Extraterritorial | 2008 |
| Sutton & Co Accountants Ltd | Professional & scientific | 2023 |