| Downtown Living Limited | Construction | 2004 |
| Doxa AI Ltd | Information & communication | 2023 |
| Dpax Limited | Hospitality | 2023 |
| DPB Spedition Limited | Professional & scientific | 2016 |
| DPG Engineering Consultancy Ltd | Other services | 2015 |
| DPS Technical Solutions Ltd | Information & communication | 2013 |
| DPW Services Ltd | Water & waste | 2023 |
| DR Harry G B Bennett Ltd | Health & social care | 2014 |
| DR Robert Thompson Limited | Health & social care | 2016 |
| DR Stephen Davies. Ltd | Professional & scientific | 2017 |
| Dragon Design & Packaging Ltd | Manufacturing | 1999 |
| Drainage Experts (NW) Ltd | Administrative & support | 2023 |
| DS Build More Ltd | Construction | 2026 |
| DT Signs Limited | Professional & scientific | 2002 |
| Dual Media Ltd | Administrative & support | 2005 |
| Duggie Chapman Associates Limited | Arts & recreation | 2017 |
| Dundee Recovery Ltd | Health & social care | 2025 |
| Dune Fmcg Interim Ltd | Professional & scientific | 2024 |
| Dune Point Management Company Limited | Households | 2006 |
| Dunholme Cross Lane Cottage Ltd | Real estate | 2023 |
| Durnin Construction Limited | Construction | 2023 |
| DWS Partners Limited | Professional & scientific | 2025 |
| E & B Merchant Options Ltd | Transport & logistics | 2018 |
| E a Gilderdale Ltd | Real estate | 2022 |
| E Carr Consulting Ltd | Information & communication | 2025 |
| E Dugdale Electrical Ltd | Construction | 2023 |
| E-Cap Investments Limited | Administrative & support | 2018 |
| E-Luxe (NW) Limited | Construction | 2024 |
| E-Sales on Line Ltd | Wholesale & retail | 2013 |
| E6 Creative Ltd | Professional & scientific | 2020 |
| Ea&C Limited | Health & social care | 2023 |
| Early Phase Services Limited | Professional & scientific | 2015 |
| East West Best Consultancy Limited | Professional & scientific | 2022 |
| Eastham Developments Limited | Professional & scientific | 1974 |
| Easypos Limited | Information & communication | 2009 |
| Easyship Limited | Transport & logistics | 2003 |
| Eaves Technical Solutions Limited | Administrative & support | 2017 |
| EC of Lytham Ltd | Construction | 2026 |
| Ecampbell Elearning Solutions Ltd | Information & communication | 2012 |
| Echelon Contracts Ltd | Construction | 2023 |
| Echelon Talent Ltd | Professional & scientific | 2024 |
| Eco-Lite Stone Limited | Extraterritorial | 2011 |
| Ecopuk Ltd | Professional & scientific | 2023 |
| Eddroo Ltd | Real estate | 2019 |
| Eddy and NAT Best Property SPV 1 Ltd | Real estate | 2025 |
| Eden Land & Development Limited | Administrative & support | 2008 |
| Edin Learning Ltd | Education | 2025 |
| Ednm Ltd | Manufacturing | 2026 |
| Edwards & Plumb Property Consulting Limited | Real estate | 2021 |
| Edwards & Plumb Property Management Limited | Real estate | 2021 |
| Effortless Recruitment Ltd | Administrative & support | 2025 |
| Efinsoft Solutions Limited | Information & communication | 2011 |
| Eight North West Limited | Hospitality | 2017 |
| EJC Engineering Ltd | Professional & scientific | 2019 |
| Ekalof Tech Ltd | Information & communication | 2024 |
| Elariun Supported Living Ltd | Health & social care | 2026 |
| ELE Developments Limited | Construction | 2019 |
| Electric Honey Tattoo Ltd | Health & social care | 2022 |
| Electric Parking Ltd | Transport & logistics | 2020 |
| Element Aquatics Limited | Wholesale & retail | 2022 |
| Eleven Z Ltd | Hospitality | 2019 |
| Elite Golf Store Limited | Wholesale & retail | 2025 |
| Elite Masonry(Nw) Ltd | Construction | 2024 |
| Elite Motorsport & Performance Ltd | Wholesale & retail | 2024 |
| Ella Media Ltd | Professional & scientific | 2017 |
| Ellian Property Investments Limited | Real estate | 2014 |
| Elliott Westbrooke UK Limited | Information & communication | 2017 |
| Elok (UK) Limited | Manufacturing | 2001 |
| Elpb Limited | Professional & scientific | 2016 |
| ELS Claims Limited | Other services | 2025 |
| ELT Rail Limited | Professional & scientific | 2017 |
| Elvins Street Food Ltd | Hospitality | 2021 |
| Em-Vie Holdings Ltd | Real estate | 2022 |
| Emily Mercer Design Limited | Professional & scientific | 2023 |
| Emmersun Limited | Information & communication | 2018 |
| Empowher Wear Ltd | Wholesale & retail | 2025 |
| Endless Pursuits Limited | Wholesale & retail | 2014 |
| Ener Services & Surveys Limited | Professional & scientific | 2017 |
| Energi House Ltd | Wholesale & retail | 2017 |
| Energi House Plumbing Ltd | Construction | 2024 |
| Energia Holdings Limited | Professional & scientific | 2015 |
| Energia Managed Services Limited | Other services | 2017 |
| Energy 64 Ltd | Administrative & support | 2026 |
| Energy Planner Limited | Professional & scientific | 2024 |
| ENG Premier Academy Coaching Ltd | Education | 2026 |
| English Academy Hub Ltd | Education | 2025 |
| Enhanced Blinds Ltd | Wholesale & retail | 2025 |
| Enhanced by Mils Ltd | Other services | 2025 |
| Enhancing Faces Training Academy Limited | Other services | 2025 |
| Ensphere Group Limited | Professional & scientific | 2015 |
| Enstone (ST. Annes) Residents Association Limited | Households | 1979 |
| Ensuite Limited | Real estate | 2016 |
| Entwistle Property Limited | Real estate | 2025 |
| Enviro-Tek Projects Ltd | Construction | 2005 |
| Epcc Ltd | Professional & scientific | 2016 |
| Equestrian & Country Estate Management Ltd | Administrative & support | 2024 |
| Eras Group Ltd | Professional & scientific | 2024 |
| Ergo One Limited | Information & communication | 2014 |
| Erlsmere BTC Limited | Financial services | 2021 |
| Erlsmere Group Limited | Real estate | 2024 |