| Shree Textiles Limited | Wholesale & retail | 2025 |
| SHS Roofing Contractors Ltd | Construction | 2020 |
| SIA Media Ltd | Professional & scientific | 2025 |
| Sicox.Music Ltd | Arts & recreation | 2024 |
| Siddle Solutions Ltd | Construction | 2022 |
| Sieluni Limited | Wholesale & retail | 2020 |
| Siemco Properties Limited | Real estate | 2020 |
| Sienna Court RTM Company Limited | Households | 2026 |
| Sigma Systems Ltd | Professional & scientific | 2013 |
| SIGMA17MEDICAL Ltd | Health & social care | 2026 |
| Sign Republic Ltd | Professional & scientific | 2022 |
| Silent Mill Brew Co Ltd | Manufacturing | 2020 |
| Silent P Limited | Professional & scientific | 2004 |
| Sillie Events Limited | Arts & recreation | 2021 |
| Silva Surveying Ltd | Professional & scientific | 2025 |
| Silver Cloud Nurseries Limited | Health & social care | 2022 |
| Silver Cloud Nursery Leyland Limited | Health & social care | 2023 |
| Silver Scorpion Limited | Professional & scientific | 2020 |
| Silverdale Computing Limited | Information & communication | 2008 |
| SIMCHRIS128 Limited | Information & communication | 2024 |
| Simkat Consultants Limited | Professional & scientific | 2008 |
| Simplicita Cremations Ltd | Other services | 2009 |
| Simply Extra Care Limited | Real estate | 2009 |
| Simplysocialmediagroup Ltd | Professional & scientific | 2020 |
| Sion Advisory Limited | Professional & scientific | 2024 |
| Sippy Ltd | Manufacturing | 2025 |
| Sixon Limited | Professional & scientific | 2022 |
| SJ Maughan Technical Support Services Ltd | Professional & scientific | 2012 |
| SJB FM Ltd | Other services | 2025 |
| SJL Technical Solutions Limited | Mining & quarrying | 2017 |
| Sjmp Property and Developments Ltd | Construction | 2022 |
| SJP Online Ltd | Information & communication | 2016 |
| SJT Digital Ltd | Information & communication | 2024 |
| SK Foods Lytham ST Annes Ltd | Hospitality | 2025 |
| SK Professionals Ltd | Administrative & support | 2025 |
| Skint Film Company Ltd | Information & communication | 2019 |
| Sleep Well Blackpool Ltd | Hospitality | 2026 |
| Slick Property Investments Ltd | Real estate | 2025 |
| SLM Agency Ltd | Health & social care | 2006 |
| SLO Hospitality Bar Ltd | Hospitality | 2025 |
| Slosh Frozen Cocktails Limited | Wholesale & retail | 2021 |
| Slowe & Whirling Limited | Administrative & support | 2019 |
| SLP Bookkeeping Ltd | Professional & scientific | 2025 |
| Slug Optic Limited | Manufacturing | 2016 |
| Slumber Sleepwear Co Ltd | Wholesale & retail | 2021 |
| SM Estates Ltd | Real estate | 2008 |
| SM Properties(Lancashire) Ltd | Real estate | 2024 |
| Smalley&Sons Building Ltd | Construction | 2023 |
| Smartech Business Solutions Limited | Information & communication | 2018 |
| SMO Group Limited | Professional & scientific | 2015 |
| SMO Outsourcing Limited | Professional & scientific | 2015 |
| SMO Research Innovations Limited | Professional & scientific | 2015 |
| SMO Services Limited | Administrative & support | 2015 |
| Smoke Stop Holdings Ltd | Financial services | 2016 |
| SMS Resources Ltd | Professional & scientific | 2015 |
| SN Legal Consulting Limited | Professional & scientific | 2025 |
| SNG Rope Access Ltd | Professional & scientific | 2017 |
| Snowmites Limited | Information & communication | 2020 |
| Sofa Master Ltd | Other services | 2023 |
| Sofatelier Limited | Extraterritorial | 2024 |
| Softreach Ltd | Professional & scientific | 2022 |
| Software Automation Ltd | Information & communication | 2023 |
| Soga Developments Ltd | Real estate | 2021 |
| Solace Point Ltd | Hospitality | 2025 |
| Solaris Generation and Storage Ltd | Construction | 2025 |
| Somic Textiles Limited | Manufacturing | 2009 |
| Sonia Morgan Podiatry Limited | Health & social care | 2018 |
| Sonrix Ltd | Health & social care | 2023 |
| Soper Group Holdings Ltd | Financial services | 2016 |
| Sophia Olivia Properties Ltd | Real estate | 2020 |
| Sorcha Property Ltd | Real estate | 2022 |
| Sorcha Systems Ltd | Information & communication | 2020 |
| Soul Smash Street Food Ltd | Hospitality | 2023 |
| Southwinds Tech Ltd | Information & communication | 2022 |
| Sozo Ltd | Professional & scientific | 2017 |
| Spacewalker Trading Ltd | Hospitality | 2025 |
| Sparway Homes Limited | Real estate | 1998 |
| Spectra Data Solutions Limited | Information & communication | 2025 |
| Spicy Waves Ltd | Hospitality | 2024 |
| Spinney Management Company (Anchorsholme) Limited(The) | Households | 1983 |
| SPL Technical Ltd | Manufacturing | 2023 |
| Spots & Stripes Products Ltd | Manufacturing | 2018 |
| Spray Granitefx Ltd | Construction | 2023 |
| Sprocket UX Limited | Information & communication | 2021 |
| Sproot Limited | Information & communication | 2014 |
| Sprp Investments Limited | Households | 2023 |
| SPS360 Limited | Construction | 2022 |
| Spsm Design Limited | Professional & scientific | 2011 |
| Sqqr Biomedical Ltd | Professional & scientific | 2022 |
| Squire Hair Limited | Wholesale & retail | 2016 |
| Squires Court Limited | Households | 1973 |
| Squires Gate Court Management Company Limited | Administrative & support | 2010 |
| SR Financial Limited | Professional & scientific | 2016 |
| SRD Consultancy Services Limited | Professional & scientific | 2007 |
| SRI Kamakshi IT Consultancy Services UK Ltd | Information & communication | 2023 |
| SRI Murugan Foundry Equipment Ltd | Manufacturing | 2023 |
| SRS Project Management Consultancy Limited | Professional & scientific | 2007 |
| ST Anne's Guitars Limited | Wholesale & retail | 2016 |
| ST Annes Beach Huts Limited | Other services | 2011 |
| ST Annes Fish Restaurant Ltd | Hospitality | 2014 |