| Ruzafa Ltd | Hospitality | 2024 |
| Ryan Joinery Services Ltd | Construction | 2025 |
| Ryecroft Limited | Construction | 2003 |
| S & B United Limited | Information & communication | 2010 |
| S & L Newburn Developments Ltd | Hospitality | 2020 |
| S & S Kitchens (Holdings) Limited | Professional & scientific | 2007 |
| S & T M Estates Ltd | Real estate | 2022 |
| S Akhtar and Associates Limited | Health & social care | 2019 |
| S E Educational Services Ltd | Professional & scientific | 2019 |
| S M Coaches Limited | Transport & logistics | 2003 |
| S Walsh Landscaping Ltd | Administrative & support | 2005 |
| S&D Real Estate Limited | Real estate | 2020 |
| S&K Housing Solutions Limited | Wholesale & retail | 2025 |
| S&N Property (Lancs) Limited | Real estate | 2019 |
| S4B Solutions Ltd | Information & communication | 2022 |
| Sadia Salam Ltd | Professional & scientific | 2018 |
| Saincouer Limited | Health & social care | 2014 |
| Sainsbury Properties Investments and Rentals Limited | Real estate | 2020 |
| Sainsbury Property Services Ltd | Real estate | 2024 |
| Sajoni Healthcare Ltd | Health & social care | 2026 |
| Sajoni Limited | Construction | 2025 |
| Sales Tech Services Ltd | Administrative & support | 2016 |
| Salia Limited | Health & social care | 2013 |
| Salient Engineering Limited | Professional & scientific | 2004 |
| Salisbury Kuczkowska Consulting Limited | Professional & scientific | 2018 |
| Salon GLO Ltd | Other services | 2020 |
| Salty Properties Limited | Real estate | 2005 |
| Salwick Estate Holdings Limited | Extraterritorial | 2017 |
| SAM Taylor Hair Ltd | Other services | 2005 |
| Samashers Ltd | Manufacturing | 2026 |
| Same Day Express North Ltd | Transport & logistics | 2020 |
| Sameday Freight Logistics Ltd | Transport & logistics | 2025 |
| Sameway Co. Ltd | Wholesale & retail | 2017 |
| Sandbanks Lytham Ltd | Real estate | 2018 |
| Sanderson Driveways & Landscapes Ltd | Administrative & support | 2025 |
| Sandgrown Consultancy Ltd. | Professional & scientific | 2010 |
| Sandgrown Ventures Ltd | Manufacturing | 2015 |
| Sandpit James Ltd | Professional & scientific | 2019 |
| Sangha Estates Lancashire Limited | Real estate | 2024 |
| Sapori Restaurant (Blackpool) Ltd | Hospitality | 2010 |
| Sapphire Cleaning & Maintenance Solutions Limited | Administrative & support | 2015 |
| Sapphire Tech Ltd | Information & communication | 2019 |
| Sarahtay Enterprises Limited | Wholesale & retail | 2025 |
| Saving AMY CIC | Manufacturing | 2020 |
| Sawthiri PVT Ltd | Wholesale & retail | 2022 |
| SBR Developments Ltd | Construction | 2015 |
| Scenario Management Ltd | Other services | 2012 |
| SCH Marine Limited | Manufacturing | 2022 |
| School Energy Matters Limited | Professional & scientific | 2012 |
| School of Antenatal Limited | Education | 2022 |
| Scope Business Solutions Limited | Information & communication | 2002 |
| Scott Digital Solutions Ltd | Information & communication | 2024 |
| Scott Winter (Holdings) Ltd | Real estate | 2021 |
| Scrooges Blackpool Ltd | Extraterritorial | 2019 |
| Scwe CIC | Education | 2023 |
| SD Brown Associates Ltd | Professional & scientific | 2015 |
| Sdml Properties Ltd | Real estate | 2025 |
| Seabourne Court (Ansdell) Limited | Households | 1968 |
| Sean Scoggins Limited | Professional & scientific | 2022 |
| Seaside Breaks Limited | Households | 2025 |
| Seaside Child Care Ltd | Health & social care | 2022 |
| Seaside Property Group Ltd | Construction | 2024 |
| SEE Sounds Limited | Other services | 2011 |
| Seemless Solutions Ltd | Information & communication | 2014 |
| Sell My Park Home Limited | Information & communication | 2014 |
| Selside Developments Ltd | Real estate | 2021 |
| SEM Construction NW Ltd | Construction | 2024 |
| SEM Joinery NW Ltd | Construction | 2024 |
| SEM Roofing Contractors Ltd | Construction | 2024 |
| Sempre Trading NW Ltd | Other services | 2021 |
| Sendcross Ltd | Administrative & support | 2025 |
| Senex Cleaning Ltd | Administrative & support | 2018 |
| Senior Moments Care LLP | | 2018 |
| Seniors Helping Seniors (Brighton & Hove) Ltd | Health & social care | 2020 |
| Sentanafisher Limited | Real estate | 2023 |
| Sequence Advisers LLP | | 2016 |
| Servicesoup Ltd | Professional & scientific | 2024 |
| Seveight Limited | Households | 1987 |
| Seven North Ltd | Extraterritorial | 2017 |
| Sewer Maintenance Company Limited | Water & waste | 2004 |
| SG Heating & GAS Services Ltd | Construction | 2021 |
| SGM Analysis Ltd | Professional & scientific | 2025 |
| SGV Elec Ltd | Construction | 2024 |
| Shadow Venues Group Ltd | Hospitality | 2021 |
| Shane Smith Grab Hire Ltd | Construction | 2016 |
| Shardale (ST Annes) Limited | Health & social care | 2013 |
| Shared Vision Ltd | Manufacturing | 2013 |
| Shark Supps Ltd | Arts & recreation | 2024 |
| Shaun Greenwood Stocktaking Limited | Administrative & support | 2008 |
| Shawwell COX Limited | Real estate | 2014 |
| Shelly Woods Limited | Arts & recreation | 2011 |
| Shepherd Arcades Limited | Arts & recreation | 2003 |
| Shepherds (Windermere) Limited | Wholesale & retail | 2019 |
| Sherlock Investigative Solutions Limited | Real estate | 2014 |
| Shift the Needle Limited | Professional & scientific | 2019 |
| Shop Bugs Limited | Wholesale & retail | 2020 |
| Shore Shine Services Ltd | Administrative & support | 2016 |
| Shoreline Estate Agents Ltd | Real estate | 2025 |
| Shorrock Lettings Limited | Real estate | 2021 |
| Show ME HOW Accountancy Ltd | Professional & scientific | 2025 |