| Solutas Limited | Professional & scientific | 2019 |
| Solutas Secure Ltd | Professional & scientific | 2025 |
| Sound View Imaging Ltd | Administrative & support | 2017 |
| Source & Sell Ltd | Professional & scientific | 2019 |
| Source Pure Limited | Wholesale & retail | 2024 |
| South Cheshire Maintenance Limited | Administrative & support | 2021 |
| Space Architecture + Property Limited | Professional & scientific | 2013 |
| Sparks of Art Ltd | Administrative & support | 2023 |
| SPC Specialist Paint Coatings Limited | Construction | 2019 |
| Specialist Inclusion Services Ltd | Administrative & support | 2023 |
| Specialist Send Group Limited | Administrative & support | 2024 |
| Spibey Electrical Limited | Construction | 2012 |
| Spice PR Ltd | Professional & scientific | 2009 |
| Sporting Holiday Group Ltd | Administrative & support | 2017 |
| Sports Planning Consultants Limited | Professional & scientific | 2022 |
| Square Pyramid Limited | Real estate | 2016 |
| Squarebridge Ltd | Information & communication | 2021 |
| Squirrels Childcare & Training Limited | Health & social care | 2019 |
| SSO Communications Limited | Administrative & support | 2016 |
| Stag Kitchens & Interiors Limited | Wholesale & retail | 2016 |
| Starley Industries Limited | Manufacturing | 2011 |
| Stathfield Limited | Construction | 2021 |
| Station 5 Technology Ltd | Information & communication | 2019 |
| Stepping Stones Nurseries(Midlands) Ltd | Health & social care | 2011 |
| Stepping Stones Nursery (Weston) Limited | Other services | 2006 |
| Steve Blears Ltd | Extraterritorial | 2013 |
| Storage Solutions Todmorden Ltd | Real estate | 2020 |
| Stretton Property Management Ltd | Real estate | 2021 |
| Studio 3822 Ltd | Administrative & support | 2024 |
| Survey Smart Ltd | Administrative & support | 2023 |
| Sutcliffe & SON (Plasterers) Limited | Construction | 1975 |
| Sutcliffe FIC Limited | Professional & scientific | 2018 |
| Swann Scientific Consulting Limited | Professional & scientific | 2014 |
| Swellaway Equine Ltd | Extraterritorial | 2014 |
| Swellaway Holdings Ltd | Extraterritorial | 2014 |
| Swellaway Ltd | Manufacturing | 2009 |
| Swift International Property Investment Limited | Real estate | 2020 |
| Swift Productions Limited | Professional & scientific | 1997 |
| Sysop Limited | Information & communication | 1985 |
| System Addict Limited | Wholesale & retail | 2005 |
| T&D Property Rentals Ltd | Real estate | 2025 |
| TAG Skip Hire Todmorden Ltd | Water & waste | 2025 |
| Talent Vista Limited | Education | 2023 |
| Talkplaces Ltd | Wholesale & retail | 2009 |
| Talon Property Ltd | Real estate | 2026 |
| Tameside Residential Ltd | Real estate | 2020 |
| Tanoshii Kaizen Ltd | Administrative & support | 2021 |
| Tdmpo Services Ltd | Other services | 2019 |
| Team R & D Limited | Wholesale & retail | 2001 |
| Tearless Kitchen Limited | Manufacturing | 2026 |
| Tempus Property Holdings Limited | Real estate | 2016 |
| TEN Four Trucking Limited | Wholesale & retail | 2022 |
| Tender Years Day Nursery (North West) Ltd | Education | 2008 |
| Testingtech Ltd | Information & communication | 2022 |
| TGD and SON Services Ltd | Transport & logistics | 2026 |
| THE Beam Education Trust | Education | 2021 |
| THE Bobbin Sisters Limited | Wholesale & retail | 2021 |
| THE Brow Management Company Limited | Administrative & support | 2007 |
| THE Cheshire SET Nail Lounge Limited | Other services | 2007 |
| THE Commsroom Ltd | Education | 2020 |
| THE Dopamine Dressing Room Ltd | Wholesale & retail | 2023 |
| THE Engine Room HQ Ltd | Administrative & support | 2025 |
| THE Filling LAB Ltd | Manufacturing | 2026 |
| THE Fourth Root Ltd | Wholesale & retail | 2026 |
| THE Grange Braintree Ltd | Real estate | 2018 |
| THE Green Nursery Limited | Education | 1991 |
| THE Grill Lymm. Ltd | Hospitality | 2025 |
| THE Hunny POT Day Nursery Limited | Education | 2003 |
| THE Jungle Day Nursery Limited | Education | 2010 |
| THE Label Hunters Ltd | Wholesale & retail | 2025 |
| THE Marigold Day Nursery Limited | Health & social care | 1995 |
| THE Mobile FD Limited | Professional & scientific | 2011 |
| THE Montessori Nursery Limited | Education | 2001 |
| THE Mvmt Room Ltd | Arts & recreation | 2020 |
| THE Owls Nursery Limited | Education | 2011 |
| THE Owls Property Limited | Real estate | 2011 |
| THE Paving Vault Ltd | Wholesale & retail | 2025 |
| THE Pennine Coffee Company Limited | Wholesale & retail | 2021 |
| THE Priory (Rushgreen Road) Management Company Limited | Administrative & support | 2002 |
| THE Prosecco POT Ltd | Wholesale & retail | 2016 |
| THE Rosebank Centre Limited | Education | 2015 |
| THE Soulful Stylist Ltd | Professional & scientific | 2021 |
| THE Training and Skills Organisation Limited | Professional & scientific | 2025 |
| THE Wendy House (Wales) Limited | Education | 2003 |
| THE Wendy House (Wirral) Ltd | Education | 2012 |
| THE Wendy House Properties (North Wales) Limited | Extraterritorial | 2012 |
| THE Wheatsheaf Bar and Grill Ltd | Hospitality | 2020 |
| THE Wine Kitchen Edinburgh Limited | Hospitality | 2025 |
| Themillwheel Limited | Hospitality | 2021 |
| Thetinroof Limited | Hospitality | 2026 |
| Thomas Turner Medical Ltd | Administrative & support | 2017 |
| Those IT Dudes Ltd | Information & communication | 2024 |
| THT Solutions Ltd | Professional & scientific | 2021 |
| TIC TOC Nursery Limited | Education | 2003 |
| Tilly and TED Homeware Limited | Wholesale & retail | 2021 |
| Tiny Teddies Day Nursery Limited | Education | 2003 |
| Tiny Tigers Childrens Day Nursery Ltd | Education | 2016 |
| Tipchip Innovations Limited | Professional & scientific | 2018 |
| TKP Ltd | Construction | 2011 |
| TMB Business Solutions Ltd | Information & communication | 2020 |