| Sonali Trading Ltd | Wholesale & retail | 2024 |
| Sonata Services Ltd | Health & social care | 2022 |
| Sonder Dance Theatre Ltd | Arts & recreation | 2019 |
| Soner Doner Kebab Ltd | Hospitality | 2023 |
| Sonix Investment Limited | Financial services | 2022 |
| Sonix Logistics Ltd | Transport & logistics | 2019 |
| Sonnexx Productions Ltd | Information & communication | 2015 |
| Sony Trans Limited | Transport & logistics | 2017 |
| SOO Limited | Professional & scientific | 2018 |
| Sopa's Beauty & Nail Academy UK Ltd | Other services | 2016 |
| Sopa's Beauty Ltd | Other services | 2015 |
| Sophantlys Ltd | Financial services | 2022 |
| Sophia Nails Ltd | Other services | 2025 |
| Soreal Signals Ltd | Construction | 2024 |
| Soroush Driving School Ltd | Education | 2023 |
| Sort Solution Ltd | Financial services | 2019 |
| Sort Surance Ltd | Financial services | 2023 |
| Sort-Out Accounting Ltd | Professional & scientific | 2024 |
| Sortsure Ltd | Financial services | 2025 |
| SOS Care Solutions Ltd | Administrative & support | 2025 |
| SOS Plumbing Services Ltd | Construction | 2022 |
| SOS Remit Ltd | Financial services | 2021 |
| Sotobe Enterprise Limited | Health & social care | 2014 |
| Soul Capone Records Limited | Wholesale & retail | 2025 |
| Soul Centred Care Services Ltd | Health & social care | 2024 |
| Soul Serenity and Beyond Ltd | Health & social care | 2020 |
| Soulgym Ltd | Wholesale & retail | 2023 |
| Soulpledge Limited | Arts & recreation | 2025 |
| Soulsmeal Services Ltd | Administrative & support | 2026 |
| Soumya Anaesthetic and Surgical Services Ltd | Professional & scientific | 2020 |
| Sound & Safe Limited | Administrative & support | 1996 |
| Sound General Building Limited | Construction | 2016 |
| Sound SEC Security Limited | Other services | 2009 |
| Source My Part Limited | Wholesale & retail | 2025 |
| Source Town Creative Limited | Information & communication | 2016 |
| Source Vista Limited | Wholesale & retail | 2023 |
| South 9 Ltd | Real estate | 2022 |
| South Beds Golf Club Ltd | Arts & recreation | 2025 |
| South Catering Group UK Ltd | Hospitality | 2024 |
| South Drift Limited | Real estate | 2017 |
| South Green Limited | Hospitality | 2015 |
| South Indian Cuisine Ltd | Hospitality | 2025 |
| South Indian Street Foods Ltd | Hospitality | 2025 |
| South Midland Steel Limited | Wholesale & retail | 1989 |
| South Squad Ltd | Hospitality | 2024 |
| South Star Roofing Ltd | Construction | 2025 |
| South Surma Investments Limited | Real estate | 2020 |
| South Woodford Cakes Limited | Wholesale & retail | 2023 |
| Southbank UK Limited | Construction | 2005 |
| Southeast Affiliates Limited | Professional & scientific | 2017 |
| Southend Rose Limited | Hospitality | 2019 |
| Southerly Apartments Ltd | Real estate | 2023 |
| Southern Coast Maritime Limited | Professional & scientific | 2022 |
| Southway Property Ltd | Real estate | 2023 |
| Sovereign Chain Limited | Information & communication | 2024 |
| Sovereign Tattoo&Piercing Limited | Wholesale & retail | 2025 |
| Sovereign Tour Operations Limited | Extraterritorial | 1990 |
| SP Food & Wine Ltd | Wholesale & retail | 2023 |
| SP Food Beds Limited | Wholesale & retail | 2026 |
| SP Foods Beds Ltd | Wholesale & retail | 2020 |
| SP Goods Limited | Wholesale & retail | 2025 |
| SP Legal Limited | Professional & scientific | 2017 |
| SP Wholesale Limited | Wholesale & retail | 2017 |
| Spa Gymnastics Academy Ltd | Arts & recreation | 2024 |
| Space Motors Limited | Wholesale & retail | 2022 |
| Spaceagent Limited | Information & communication | 1995 |
| Spacecoshare Ltd | Administrative & support | 2017 |
| Spanyol Betyar Ltd | Transport & logistics | 2024 |
| Spara Investments Limited | Extraterritorial | 2025 |
| Spark &Serve Ltd | Hospitality | 2026 |
| Spark Aura Ltd | Wholesale & retail | 2024 |
| Spark Buddy Limited | Manufacturing | 2024 |
| Spark Novva Ltd | Wholesale & retail | 2026 |
| Sparkify Ltd | Manufacturing | 2025 |
| Sparkle & Shine by Lisa Toye Ltd | Administrative & support | 2025 |
| Sparkle and Polish Limited | Administrative & support | 2025 |
| Sparkle and Shine Maids Ltd | Construction | 2023 |
| Sparkle MK Ltd | Administrative & support | 2026 |
| Sparklestouch Ltd | Administrative & support | 2025 |
| Sparkling and Shining Stars Ltd | Health & social care | 2019 |
| Sparkling Klean Ltd | Administrative & support | 2020 |
| Sparklithic Ltd | Information & communication | 2022 |
| Sparkys Corner Ltd | Other services | 2013 |
| Sparo Limited | Transport & logistics | 2018 |
| Sparta Telecom Ltd. | Information & communication | 2011 |
| Spartans INV Ltd | Real estate | 2026 |
| Spartans Law Limited | Professional & scientific | 2018 |
| SPB Electrical Solutions Limited | Construction | 2017 |
| SPC Distributions Ltd | Wholesale & retail | 2024 |
| Special Education Need T S Ltd | Transport & logistics | 2025 |
| Special Glow Cleaning Services Ltd | Administrative & support | 2023 |
| Special Sameday Service Limited | Transport & logistics | 2021 |
| Specialist in Continuing Healthcare Limited | Health & social care | 2018 |
| Specialist Interpreting Ltd | Professional & scientific | 2014 |
| Specialists Performance Cars Ltd | Wholesale & retail | 2023 |
| Specialized Caretakers Ltd | Health & social care | 2025 |
| Specslab (Home Counties) Limited | Health & social care | 2006 |
| Specter North-East Ltd | Financial services | 2018 |
| Spectre Homes Ltd | Real estate | 2025 |
| Spectre Law Ltd | Professional & scientific | 2024 |