| Salkaara Kitchen Ltd | Hospitality | 2025 |
| Salla Ltd | Construction | 2026 |
| Salon 11 Ltd | Other services | 2019 |
| Salon Aura Ltd | Other services | 2024 |
| Salon Cafe Limited | Other services | 2026 |
| Salon Sara Limited | Other services | 2025 |
| Salon SJ Limited | Other services | 2020 |
| Salsabel Limited | Wholesale & retail | 2026 |
| Salsabil Ornaments Limited | Wholesale & retail | 2021 |
| Salt and Light Therapy Limited | Extraterritorial | 2022 |
| Salto Gymnastics Charitable Foundation Limited | Education | 2003 |
| Salvage Ltd | Information & communication | 2005 |
| Salvage Plus Ltd | Wholesale & retail | 2023 |
| Salvation Coaching Company Limited | Professional & scientific | 2002 |
| Salvator Automotive Ltd | Administrative & support | 2022 |
| Salzoy Ltd | Wholesale & retail | 2021 |
| SAM & Co Group Ltd | Wholesale & retail | 2018 |
| SAM Cars Bay Ltd | Wholesale & retail | 2019 |
| SAM Lofts Limited | Construction | 2017 |
| SAM Magnet Exports (UK) Ltd | Water & waste | 2026 |
| SAM Magnet UK Limited | Water & waste | 2010 |
| SAM Motor Services Ltd | Wholesale & retail | 2023 |
| SAM UK Estate Ltd | Real estate | 2024 |
| Sam's Beauty Booth Ltd | Other services | 2018 |
| Samad Overseas Service Ltd | Financial services | 2011 |
| Samantha Reddington Limited | Professional & scientific | 2020 |
| Samaritan Films Ltd | Information & communication | 2026 |
| Samavia Limited | Transport & logistics | 2022 |
| Samawat Ltd | Wholesale & retail | 2025 |
| Sambyal Halal Meats Ltd | Wholesale & retail | 2021 |
| Samcargos Limited | Transport & logistics | 2015 |
| Samedialabs Ltd | Administrative & support | 2011 |
| Samfza Ltd | Wholesale & retail | 2021 |
| Sami Brothers Ltd | Wholesale & retail | 2024 |
| Samiha Chowdhury Ltd | Health & social care | 2021 |
| Samira Enterprise Limited | Wholesale & retail | 2026 |
| Samkuma Ltd | Health & social care | 2019 |
| Sammy Consultants Ltd | Extraterritorial | 2017 |
| Samo Construction Ltd | Construction | 2026 |
| Sampi Ltd | Transport & logistics | 2023 |
| Samror Amberley Limited | Real estate | 2023 |
| Sams & S Company Ltd | Administrative & support | 2018 |
| Sams Heating & Plumbing Solutions Ltd | Construction | 2018 |
| Samsandy Ltd | Transport & logistics | 2026 |
| Samsonartist Ltd | Wholesale & retail | 2023 |
| Samuel Holdings Limited | Real estate | 2023 |
| Samuel Safo & Co Ltd | Construction | 2015 |
| Samurai Autos Ltd | Wholesale & retail | 2025 |
| Samy&Samy Transport Ltd | Transport & logistics | 2026 |
| Sam’S Greek Pitta Ltd | Hospitality | 2024 |
| SAN Commerce Ltd | Wholesale & retail | 2024 |
| Sana Property Ltd | Real estate | 2025 |
| Sanaaz Ltd | Real estate | 2024 |
| Sanabi Limited | Wholesale & retail | 2024 |
| Sanabil Ltd | Information & communication | 2016 |
| Sanatain Limited | Education | 2019 |
| Sanchorawala Ltd | Hospitality | 2025 |
| Sanctuary Serene Clean Limited | Extraterritorial | 2024 |
| Sanctus Heating Ltd | Wholesale & retail | 2025 |
| Sandbyte Limited | Information & communication | 2025 |
| Sander Property Limited | Real estate | 2017 |
| Sanderson Jewellery Group Ltd | Wholesale & retail | 2023 |
| Sandhill Close Management Company Limited | Construction | 2020 |
| Sandhu Autos Ltd | Wholesale & retail | 2024 |
| Sandhu Driveway Ltd | Construction | 2024 |
| Sandhu Travel Ltd | Transport & logistics | 2024 |
| Sandhurst Investments Limited | Real estate | 1957 |
| Sandpiper Court Limited | Real estate | 2013 |
| Sandsure Ltd | Construction | 2023 |
| Sandu.San Ltd | Construction | 2026 |
| Sandwich Luton Ltd | Hospitality | 2021 |
| Sandy Courier Ltd | Transport & logistics | 2021 |
| Sandy Enterprises Ltd | Transport & logistics | 2020 |
| Sandy Hill Limited | Hospitality | 2017 |
| Sanfan Limited | Information & communication | 2015 |
| Sangeen Mini Market Ltd | Wholesale & retail | 2026 |
| Sanha Traders Ltd | Hospitality | 2023 |
| Sanj Transport Ltd | Transport & logistics | 2026 |
| Sanjude Care Limited | Health & social care | 2015 |
| Sanka Trans Limited | Other services | 2016 |
| Sankefullon Ltd | Transport & logistics | 2019 |
| Santhos Food & Wine Ltd | Administrative & support | 2018 |
| Santillo 2006 Ltd | Hospitality | 2006 |
| Santillo 2018 Limited | Real estate | 2018 |
| Santillo Brothers Ltd | Real estate | 2006 |
| Santos Transport Services Ltd | Transport & logistics | 2026 |
| Sany Cleaning Limited | Administrative & support | 2016 |
| SAP IT Limited | Information & communication | 2019 |
| Sapanta Ltd | Construction | 2012 |
| Sapna Clothes Limited | Wholesale & retail | 2020 |
| Sapo Constructions Ltd | Construction | 2025 |
| Sapphire AD Ltd | Transport & logistics | 2026 |
| Sapphire Hospitality Limited | Wholesale & retail | 2015 |
| Sapphire Properties MK Ltd | Real estate | 2020 |
| Sapphire Property Specialists Limited | Real estate | 2019 |
| Sapphires Decor Limited | Wholesale & retail | 2021 |
| Sapporo Consultancy Limited | Administrative & support | 2026 |
| SAR Grocery Luton Limited | Wholesale & retail | 2024 |
| Sara Estates Luton Ltd | Real estate | 2022 |
| Sara Hamid Limited | Wholesale & retail | 2024 |