| Safe Cylinders Limited | Extraterritorial | 2014 |
| Safe Facility Managements Limited | Administrative & support | 2025 |
| Safe Ground Work & Utilities Ltd | Construction | 2023 |
| Safe Haven Care and Support Ltd | Health & social care | 2023 |
| Safe Journeys Ltd | Administrative & support | 2016 |
| Safe Line Trading Company Limited | Information & communication | 2026 |
| Safe Place & Adventures Ltd | Real estate | 2023 |
| Safe Plumber and GAS Engineer Ltd | Construction | 2021 |
| Safe Policies Ltd | Professional & scientific | 2023 |
| Safe Sedation Services Limited | Health & social care | 2016 |
| Safe Travel and Tours Ltd | Administrative & support | 2024 |
| Safe-T Electrics Ltd | Energy | 2013 |
| SAFE2BUY Global Ltd | Wholesale & retail | 2024 |
| Safecert Skills Ltd | Construction | 2024 |
| Safeco Machinery Limited | Wholesale & retail | 2023 |
| Safeer Asif Ltd | Wholesale & retail | 2024 |
| Safeguard PMS Ltd | Other services | 2017 |
| Safeguard Roofing Solutions Limited | Construction | 2026 |
| Safeguarding and Behaviour Consultancy Ltd | Education | 2024 |
| Safekeep Hub Ltd | Health & social care | 2023 |
| Safepoint Logistics Ltd | Transport & logistics | 2025 |
| Safero Limited | Wholesale & retail | 2025 |
| Safetrans George Ltd | Transport & logistics | 2021 |
| Safex Intelligence Ltd | Information & communication | 2025 |
| Saffron A5 Ltd | Hospitality | 2015 |
| Saffron Enterprises Ltd | Wholesale & retail | 2024 |
| Saffron Indian Restaurant (UK) Limited | Extraterritorial | 2015 |
| Saffron Plaza Ltd | Hospitality | 2012 |
| Saffron Walden Takeaway Ltd | Hospitality | 2022 |
| Saffron Water Ltd | Manufacturing | 2025 |
| Safiya Investment UK Ltd | Real estate | 2023 |
| Safk Properties Ltd | Financial services | 2021 |
| Safri Enterprises KH Ltd | Construction | 2020 |
| Saft Limited | Manufacturing | 1937 |
| Saftec Limited | Administrative & support | 2007 |
| Saftex Trading Limited | Information & communication | 2025 |
| Saftey Masters Ltd | Wholesale & retail | 2018 |
| SAG Transport Ltd | Transport & logistics | 2019 |
| Saga Facilities Ltd | Administrative & support | 2021 |
| Sagala Limited | Construction | 2025 |
| Sagano Properties Ltd | Households | 2022 |
| Sage Ideal Properties Ltd | Real estate | 2023 |
| Sage Orin Ltd | Hospitality | 2025 |
| Saggu Transport Limited | Transport & logistics | 2025 |
| Sagoo Capital Limited | Information & communication | 2023 |
| Sagron Builders Ltd | Construction | 2020 |
| Sahaba Recruitment Ltd | Administrative & support | 2022 |
| Sahar Services UK Ltd | Financial services | 2020 |
| Sahar Travel UK Ltd | Administrative & support | 2024 |
| Sahi & Sahi Limited | Real estate | 2026 |
| Sahi Estates Limited | Real estate | 2025 |
| Sahi Services Limited | Construction | 2017 |
| Sahib Property Management Limited | Real estate | 2024 |
| Sahib's Three Daimond Bar & Grill Ltd | Hospitality | 2024 |
| Sahibwal Services Ltd | Administrative & support | 2021 |
| Sahid Ltd | Other services | 2025 |
| Sahil Construction Ltd | Construction | 2006 |
| Sahithi Limited | Information & communication | 2025 |
| Sahra 24 Ltd | Hospitality | 2020 |
| Sahtexh Solutions Ltd | Administrative & support | 2019 |
| Sahussain Consultancy Ltd | Education | 2021 |
| Sahwr | Administrative & support | 1998 |
| SAI Aesthetics Ltd | Other services | 2018 |
| SAI Global Ltd | Information & communication | 2020 |
| SAI Growing Little Minds Ltd | Health & social care | 2022 |
| SAI Prime Investments LLP | | 2019 |
| Saicres Ltd | Real estate | 2026 |
| Saifanav Ltd | Administrative & support | 2024 |
| Saii Essentials Ltd | Wholesale & retail | 2024 |
| Saik Ltd | Wholesale & retail | 2025 |
| Saimla Limited | Information & communication | 2026 |
| Sain Delivery Ltd | Transport & logistics | 2023 |
| Sain Investments Limited | Real estate | 2023 |
| Saint Aims Care and Support Ltd | Health & social care | 2022 |
| Saint Michael Ambulance Limited | Transport & logistics | 2024 |
| Saints Fast Food Ltd | Hospitality | 2025 |
| Sainy Ltd | Wholesale & retail | 2026 |
| Sair FM Limited | Construction | 2021 |
| Saizar Limited | Real estate | 2025 |
| Sajada Property Ltd | Real estate | 2025 |
| Sajeena Homes Limited | Hospitality | 2022 |
| Sajj's CAB & Car Repairs Limited | Wholesale & retail | 2018 |
| Sajjad Anwar Limited | Financial services | 2025 |
| Sajjad Cars Ltd | Transport & logistics | 2012 |
| Sajnani Enterprise UK Limited | Health & social care | 2013 |
| Sajz Property Solutions Ltd | Extraterritorial | 2021 |
| Sakm Golden Nest Ltd | Real estate | 2025 |
| SAL Transportt Limited | Transport & logistics | 2023 |
| Salaams Healthcare Limited | Health & social care | 2025 |
| Salaamseeker Ltd | Education | 2021 |
| Salajan Group Ltd | Transport & logistics | 2023 |
| Salajan Tiling L Limited | Construction | 2014 |
| Salam Construction Management Ltd | Construction | 2024 |
| Salamon Construction Ltd | Construction | 2020 |
| Salavath Builds Ltd | Construction | 2026 |
| Saleem & Sons Limited | Hospitality | 2026 |
| Salim & Daughters Ltd | Real estate | 2026 |
| Salim Travel & Tourism Limited | Administrative & support | 2018 |
| Salisbury Capital Real Estate Partners Ltd | Real estate | 2023 |
| Salkaara Catering Limited | Hospitality | 2026 |