| Station Taxis (Malton) Ltd | Transport & logistics | 2019 |
| Status BUS and Coach Limited | Financial services | 1999 |
| Stay on the BUS - Navigating Breast Cancer CIC | Health & social care | 2025 |
| Stay Unique Limited | Health & social care | 2025 |
| Staylong Limited | Real estate | 2000 |
| Stayproactive Consulting Ltd | Professional & scientific | 2025 |
| Stayz Properties Ltd | Real estate | 2022 |
| STB Direct Marketing Ltd | Administrative & support | 2005 |
| STB Solutions Limited | Information & communication | 2003 |
| Steady Care Solutions Limited | Health & social care | 2023 |
| Steanne Solutions Limited | Information & communication | 2006 |
| Stedcombe Farm Management Limited | Households | 1987 |
| Steel Fusion Designs Ltd | Professional & scientific | 2025 |
| Stefanie Reid Limited | Arts & recreation | 2010 |
| Steggles Holdings Limited | Financial services | 2026 |
| Sterling Education Limited | Education | 2013 |
| Sterling Investments (Oadby) Limited | Real estate | 1994 |
| Sterling Professional Services UK Limited | Professional & scientific | 2024 |
| Stern Graff Limited | Information & communication | 2015 |
| Steve Blackshaw Consulting Limited | Professional & scientific | 2017 |
| Steve Bower Joinery and Manufacturing Limited | Manufacturing | 2012 |
| Steve Chalmers Limited | Administrative & support | 2009 |
| Steve Olds Sofa Designs Ltd | Manufacturing | 2025 |
| Steve Slattery MOT & Service Centre Ltd | Wholesale & retail | 2024 |
| Steve Vernon Limited | Other services | 2026 |
| Steven LUA Limited | Financial services | 2020 |
| Steven LUA Ventures Limited | Financial services | 2020 |
| Stick & Ribbon Ltd | Wholesale & retail | 2010 |
| Stiff Wheels Ltd | Manufacturing | 2021 |
| Still ILL Ltd | Arts & recreation | 2015 |
| Stirling Lloyd Polychem Limited | Manufacturing | 1989 |
| Stirling Lloyd Products International Limited | Extraterritorial | 1990 |
| Stme Technical Services Limited | Professional & scientific | 2013 |
| Stockclause Limited | Extraterritorial | 1999 |
| Stoked Limited | Manufacturing | 2003 |
| Stonebow Primary School | Education | 2013 |
| Stonepharma Limited | Professional & scientific | 2022 |
| Stonerigg Consulting Limited | Professional & scientific | 2017 |
| Stones and Matheson Ltd | Real estate | 2025 |
| Stonesbridge Corporate Advisory Limited | Professional & scientific | 2021 |
| Storacall Voice Systems (2019) Limited | Information & communication | 2019 |
| Storage in Loughborough Limited | Real estate | 2009 |
| Store It-Uk Ltd | Real estate | 2021 |
| Story and Search Ltd | Professional & scientific | 2021 |
| Story Sense Franchise Ltd | Arts & recreation | 2026 |
| Stowe Hm-Pb Limited | Financial services | 2025 |
| STR Consultancy Ltd | Information & communication | 2025 |
| Strafford Interiors Limited | Construction | 1996 |
| Straw & Pearce Financial Management LLP | | 2013 |
| Straw and Pearce Ltd | Professional & scientific | 2024 |
| Streaminto Ltd | Financial services | 2023 |
| Streamrecruitmentuk Ltd | Administrative & support | 2025 |
| Street Design Limited | Manufacturing | 1986 |
| Street Fit Installations Ltd | Construction | 2025 |
| Street International Holdings Limited | Financial services | 2018 |
| Street Lets Flats Limited | Real estate | 2020 |
| Strength Business Mastery Limited | Professional & scientific | 2024 |
| Stresscraft Limited | Professional & scientific | 1987 |
| Strike MAP UK Ltd | Other services | 2020 |
| Strip-It Limited | Other services | 2013 |
| Stroudy IT Limited | Information & communication | 2009 |
| Stuart Smith Transport Ltd | Transport & logistics | 2020 |
| Studio Base Ltd | Information & communication | 2019 |
| Studio Elevate Ltd | Information & communication | 2023 |
| Studio Fish Ltd | Wholesale & retail | 2023 |
| Studio M Fitness Ltd | Arts & recreation | 2021 |
| Stumpclear Ltd | Agriculture & fishing | 2026 |
| Stylish Productions Ltd | Other services | 2022 |
| Subira Limited | Professional & scientific | 2026 |
| Submersible Motor Engineering (UK) Ltd | Manufacturing | 2016 |
| Suborbital UK Ltd | Manufacturing | 2019 |
| Subsea Plasma Limited | Extraterritorial | 1987 |
| Succeed Group Limited | Professional & scientific | 2016 |
| Succeed-Ed Limited | Education | 2013 |
| Sudhi R Verma (SRV) Ltd | Health & social care | 2021 |
| SUE Griffiths Consulting Limited | Other services | 2015 |
| Suhasini Ropana Ltd | Health & social care | 2022 |
| Suki Gifts International Limited | Wholesale & retail | 2011 |
| Sultan Barber Loughborough Ltd | Other services | 2023 |
| Sultan BBQ Ltd | Hospitality | 2019 |
| Summer Logistics Ltd | Other services | 2018 |
| Sunday Records Limited | Hospitality | 2017 |
| Sunken Hollow Limited | Other services | 2015 |
| Sunnyfy Entertainments Ltd | Arts & recreation | 2021 |
| Sunray Services Limited | Administrative & support | 2018 |
| Sunrise Digital Marketing UK Ltd | Information & communication | 2026 |
| Sunrise Eggs Holdings Limited | Professional & scientific | 2015 |
| Sunrise Poultry Farms Limited | Agriculture & fishing | 1973 |
| Sunset Catering Equipment Ltd | Manufacturing | 2023 |
| Super Bobble Ltd | Transport & logistics | 2023 |
| Super Sumo Limited | Manufacturing | 2003 |
| Super Vape INT Ltd | Wholesale & retail | 2026 |
| Superfix Limited | Extraterritorial | 2006 |
| Supermario Desing Ltd | Wholesale & retail | 2024 |
| Supersam Savanah Ltd | Wholesale & retail | 2020 |
| Support & Connections Ltd | Health & social care | 2012 |
| Supreme Fish Bar Limited | Wholesale & retail | 2006 |
| Suraj Property Ltd | Real estate | 2021 |
| Surecare (Loughborough) Ltd | Health & social care | 2026 |
| Surepipe Plumbing & Mechanical Pipeline Services Limited | Manufacturing | 2004 |