| Solutions Asset Management Limited | Professional & scientific | 2025 |
| Solventum UK Holding Company Ltd | Financial services | 2023 |
| SOM: Simply Organised Money Limited | Professional & scientific | 2017 |
| Something Visual Limited | Arts & recreation | 2006 |
| Somex Properties Limited | Real estate | 2021 |
| Soph on Social Ltd | Information & communication | 2023 |
| Sorrel Barbers Limited | Other services | 2017 |
| Sotex International Limited | Wholesale & retail | 1976 |
| Souffle Limited | Hospitality | 2023 |
| Sound Barrier Solutions Limited | Professional & scientific | 1998 |
| Soundbox Events Ltd | Other services | 2008 |
| Sourct Ltd | Professional & scientific | 2023 |
| South Brothers Limited | Wholesale & retail | 2020 |
| South Notts Landscaping and Maintenance Ltd | Administrative & support | 2025 |
| South Wigston Hand Car Wash Ltd | Other services | 2023 |
| Sovereign Court RTM Company Limited | Households | 2008 |
| Sovereign Projects Limited | Wholesale & retail | 1992 |
| Sowle Company Limited | Education | 2021 |
| SP Bespoke Wellbeing Solutions Limited | Health & social care | 2021 |
| SP Golden Ltd | Administrative & support | 2021 |
| SP Golden Solutions Limited | Administrative & support | 2021 |
| SP Sales & Lettings Ltd | Real estate | 2017 |
| Space Outdoor Signage Limited | Professional & scientific | 2020 |
| Spaces Investment Limited | Real estate | 2022 |
| Spare Bricks Limited | Real estate | 2013 |
| Spare Prop Limited | Real estate | 2019 |
| Sparrow Hill International Limited | Wholesale & retail | 2025 |
| Sparrow Hill PUB Company Limited | Hospitality | 2025 |
| Special Occasions (Midlands) Limited | Wholesale & retail | 2013 |
| Specialised Groundcare Ltd | Agriculture & fishing | 2004 |
| Spectrum Slices Ltd | Hospitality | 2025 |
| Speculoos Limited | Households | 2025 |
| Speedster Cars Ltd | Wholesale & retail | 2024 |
| Spencer Hall Mortgages Ltd | Financial services | 2020 |
| Spencer Hill Growth Partners Ltd | Professional & scientific | 2021 |
| Spencer's Kitchen Ltd | Hospitality | 2020 |
| Spice Cube Kitchen Limited | Hospitality | 2021 |
| Spice Cube Restaurant Limited | Hospitality | 2019 |
| Spice Lounge (Shepshed) Limited | Hospitality | 2016 |
| Spicee UPP Ltd | Hospitality | 2014 |
| Spinnaker Innovation Ltd | Professional & scientific | 2015 |
| Spinners Law Limited | Professional & scientific | 2024 |
| Spirit Link Distribution Ltd | Wholesale & retail | 2025 |
| Spirit Sculpture Limited | Arts & recreation | 2013 |
| Spit and Sparkle Ltd | Administrative & support | 2026 |
| Splendid Apple Limited | Information & communication | 2011 |
| Sport Make Your Day Limited | Wholesale & retail | 2025 |
| Sports Advocate Limited | Wholesale & retail | 2010 |
| Sports Installations Limited | Construction | 2003 |
| Sportstechlab Ltd | Wholesale & retail | 2010 |
| Spotlight Analysis Ltd | Arts & recreation | 2021 |
| SPP Manufacturing Limited | Manufacturing | 2024 |
| Spray Plaster Specialists Ltd | Construction | 2011 |
| Springhill Properties(Donington)Limited | Real estate | 1959 |
| Springvale Energies Limited | Energy | 2013 |
| Springvale Farm & Haulage Limited | Agriculture & fishing | 2011 |
| Springvale Fishing Lakes Limited | Agriculture & fishing | 2010 |
| Springvale Lane Limited | Extraterritorial | 2009 |
| Springvale Park Limited | Hospitality | 2009 |
| Springvale Retirement Living Limited | Extraterritorial | 2017 |
| Springvale Retreat Limited | Hospitality | 2019 |
| Springven Living Limited | Health & social care | 2025 |
| Sprinkleaspark Ltd | Information & communication | 2024 |
| Spud Group Ltd | Hospitality | 2025 |
| Spudmax Ltd | Hospitality | 2025 |
| Spuds of Shepshed Limited | Hospitality | 2025 |
| Spur and West Ltd | Construction | 2014 |
| Squair Care Limited | Wholesale & retail | 2006 |
| Square Lemon Ltd | Manufacturing | 2022 |
| Square Limited | Extraterritorial | 2001 |
| Square Necessities Limited | Arts & recreation | 2026 |
| Square Storage Limited | Administrative & support | 2014 |
| Squeaky Clean Smiles Ltd | Health & social care | 2024 |
| Sr-Vapes Trade Ltd | Wholesale & retail | 2015 |
| SRD Transport Ltd | Transport & logistics | 2024 |
| Srdb Health Partners Limited | Health & social care | 2025 |
| SS Consolidated Ltd | Real estate | 2024 |
| SSJ Partners Limited | Construction | 2024 |
| Ssmart Kids Private Tutorials Limited | Education | 2022 |
| Ssrb Construction Ltd | Construction | 2026 |
| Ssss Consultancy Limited | Education | 2025 |
| SSV Corporation Ltd | Wholesale & retail | 2023 |
| ST George Hardware Limited | Wholesale & retail | 2017 |
| Staah Europe Limited | Information & communication | 2017 |
| Stac Consult Limited | Professional & scientific | 2016 |
| Stack Deliveries Private Limited | Information & communication | 2026 |
| Stack Estates Limited | Manufacturing | 2004 |
| Stack Utilities Ltd | Information & communication | 2024 |
| Staffordshire Spine Clinic (VJ) Limited | Health & social care | 2010 |
| Stahl UK Limited | Manufacturing | 1999 |
| Stainless Art Limited | Professional & scientific | 2001 |
| Stand OUT Leadership Limited | Information & communication | 2026 |
| Stanley Bott Transport Ltd | Transport & logistics | 2013 |
| Stanshawe Engineering Consultants Limited | Professional & scientific | 2005 |
| Stapletor Limited | Professional & scientific | 2018 |
| Star Express Courier Ltd | Transport & logistics | 2026 |
| Star Index Ltd | Information & communication | 2019 |
| Starke Arvid Limited | Administrative & support | 2005 |
| Starlight Secure Transport Ltd | Transport & logistics | 2024 |
| Starry-Eyed Pragmatics Limited | Professional & scientific | 2024 |