| Scratch Crew Skateboarding Ltd | Wholesale & retail | 2025 |
| Screen Positive Limited | Information & communication | 2015 |
| Screenflow.Ai Ltd | Information & communication | 2024 |
| Screenlab Liverpool Ltd | Information & communication | 2024 |
| Screenlife Liverpool Limited | Information & communication | 2021 |
| Scribe Associates Ltd | Administrative & support | 2014 |
| Scribe Kitchen Supplies Limited | Construction | 2025 |
| Scribeshopfitting UK Ltd | Construction | 2013 |
| Script Circle CIC | Education | 2025 |
| Script Happens Ltd | Information & communication | 2025 |
| Scriptable Ltd | Information & communication | 2013 |
| Scriptdog Limited | Arts & recreation | 2018 |
| Scripted Socials Ltd | Professional & scientific | 2021 |
| Scriptly Ltd | Information & communication | 2025 |
| Scrubbed Cleaning Ltd | Administrative & support | 2025 |
| Scruffs Hair Ltd | Other services | 2024 |
| Scrutiny and Empowerment Partners Limited | Professional & scientific | 2011 |
| SCS Distributions Ltd | Wholesale & retail | 2026 |
| Scully Ltd | Real estate | 2016 |
| Sculpt @ 72 Ltd | Other services | 2024 |
| Sculpted Sirens Limited | Health & social care | 2026 |
| Sculpture Hair Limited | Professional & scientific | 2012 |
| Scunthorpe Freight Services Ltd | Transport & logistics | 2024 |
| SD 1 Civils Ltd | Construction | 2024 |
| SD Administration Ltd | Administrative & support | 2019 |
| SD Barber Shop Limited | Other services | 2025 |
| SD Developments Liverpool Ltd | Real estate | 2023 |
| SD Group (NW) Ltd | Financial services | 2019 |
| SD Guthrie International Liverpool Refinery Limited | Administrative & support | 2008 |
| SD Malone Limited | Health & social care | 2024 |
| SD Project Management NW Ltd | Professional & scientific | 2024 |
| SD Properties (NW) Ltd | Real estate | 2019 |
| SD Solutions North West Ltd | Professional & scientific | 2026 |
| SDB Electrical Contractors Ltd | Construction | 2010 |
| Sdbf Property Ltd | Real estate | 2025 |
| SDE Hair Ltd | Wholesale & retail | 2022 |
| Sdfb Asset Management Ltd | Real estate | 2024 |
| Sdfb Developments Ltd | Construction | 2024 |
| Sdfb Housing Ltd | Real estate | 2023 |
| Sdfb Ltd | Wholesale & retail | 2021 |
| Sdfb Property Management Ltd | Real estate | 2023 |
| SDG Foods Ltd | Hospitality | 2015 |
| SDG1878 Ltd | Households | 2024 |
| SDH Northwest Limited | Financial services | 2013 |
| SDJ Telecoms Ltd | Information & communication | 2024 |
| SDK11 Ltd | Hospitality | 2025 |
| SDL11 Ltd | Hospitality | 2025 |
| SDL13 Ltd | Hospitality | 2025 |
| SDL24 Ltd | Hospitality | 2025 |
| SDL3 Ltd | Hospitality | 2025 |
| SDL8 Ltd | Hospitality | 2025 |
| Sdni Trans Ltd | Transport & logistics | 2024 |
| SDP67 Ltd | Professional & scientific | 2026 |
| SDS Electrical Services Ltd | Construction | 2024 |
| SDS Food Ltd | Hospitality | 2025 |
| SDS Heating and Plumbing Ltd | Construction | 2018 |
| SDS Interiors Ltd | Construction | 2024 |
| SDS Investments Limited | Transport & logistics | 2011 |
| Sds-Uk Ltd | Wholesale & retail | 2024 |
| Sdsb Limited | Households | 2022 |
| SDW Property Services Ltd | Real estate | 2017 |
| SE Liverpool Ltd | Other services | 2020 |
| Sea CAP. Limited | Hospitality | 2020 |
| Sea Lettings Ltd | Real estate | 2018 |
| Sea Trade Holdings Limited | Professional & scientific | 2023 |
| Sea YOU Ltd | Wholesale & retail | 2017 |
| Seabridge Fish Bar Ltd | Hospitality | 2024 |
| Seabright Enterprise Limited | Real estate | 2016 |
| Seacroft Trading Limited | Professional & scientific | 2021 |
| Seadrill Management Ltd. | Mining & quarrying | 2012 |
| Seadrill Treasury UK Limited | Professional & scientific | 2018 |
| Seadrill UK Ltd. | Administrative & support | 2008 |
| Seaforth Group Ltd | Other services | 2019 |
| Seaforth Haulage Contractors Limited | Transport & logistics | 2002 |
| Seaforth Information Network Group | Administrative & support | 1997 |
| Seaforth P O & News Ltd | Wholesale & retail | 2019 |
| Seaforth Quick Valeting Ltd | Hospitality | 2019 |
| Seaforth Radio Cars Limited | Transport & logistics | 2006 |
| Seaforth Shop Ltd | Wholesale & retail | 2025 |
| Seagrave Property Limited | Real estate | 2023 |
| Seagull Aerial Survey & Photography Ltd | Professional & scientific | 2019 |
| Seagull Maritime Services Ltd | Transport & logistics | 2020 |
| Seagull's Choice Limited | Wholesale & retail | 2021 |
| Seahorse Communications Limited | Information & communication | 1997 |
| Seairo Shipping Limited | Administrative & support | 2004 |
| Seal Real Estate Ltd | Real estate | 2026 |
| Seal Smart Waterproofing Solutions Ltd | Transport & logistics | 2023 |
| Sealand Limited | Health & social care | 2012 |
| Sealand Management Limited | Households | 2002 |
| Seamless Support Limited | Health & social care | 2025 |
| Seamline Limited | Manufacturing | 2020 |
| Seamster & Shepherd Limited | Manufacturing | 2024 |
| Sean Clarke Ltd | Construction | 2026 |
| Sean Crowley Boxing and Fitness Ltd | Administrative & support | 2016 |
| Sean Doherty Construction Ltd | Construction | 2015 |
| Sean James Heating & Plumbing Ltd | Construction | 2010 |
| Sean Matthew Construction Ltd | Construction | 2025 |
| Sean Patrick Media Ltd. | Professional & scientific | 2022 |
| Sean Pearce Motion Design Limited | Information & communication | 2019 |
| Sean Salmon Limited | Professional & scientific | 2013 |