| Scale Distribution Ltd | Transport & logistics | 2000 |
| Scallons Auto Services Limited | Wholesale & retail | 2019 |
| Scan Point 3D Ltd. | Other services | 2022 |
| Scancon Holding Ltd | Manufacturing | 2017 |
| Scandinavian Builders & Renovations Ltd | Construction | 2024 |
| Scanfocus Ltd | Wholesale & retail | 2021 |
| Scanguardian Ltd | Administrative & support | 2018 |
| Scanlock (UK) Ltd. | Wholesale & retail | 1993 |
| Scar Holdings Ltd | Financial services | 2025 |
| Scar Industries Ltd | Construction | 2016 |
| Scar Investment Ltd | Real estate | 2025 |
| Scar Propertys Ltd | Real estate | 2024 |
| Scargreen Avenue Management Company Limited | Households | 2005 |
| Scargreen Retail Limited | Wholesale & retail | 2019 |
| Scargreen Scran’S Limited | Hospitality | 2026 |
| Scarisbrick Gardens Management Company Limited | Construction | 2024 |
| Scarisbrick New Road Ltd | Real estate | 2021 |
| Scary Monster Ltd | Information & communication | 2021 |
| Scatterson Properties Limited | Real estate | 2023 |
| SCB Property Ltd | Real estate | 2016 |
| Scdc Investments Ltd | Real estate | 2024 |
| Sceneryy Ltd | Wholesale & retail | 2024 |
| Scentwise Group Limited | Wholesale & retail | 2025 |
| SCG Engineering Services Limited | Construction | 2022 |
| SCH Consulting Limited | Other services | 2025 |
| Schaef Systemtechnik Limited | Information & communication | 2005 |
| Schake Limited | Financial services | 2012 |
| Schalkx Conservation Limited | Arts & recreation | 2024 |
| Schedule 12 Limited | Administrative & support | 2019 |
| Schmechel Enterprises Ltd | Wholesale & retail | 2025 |
| Schmooze! Limited | Arts & recreation | 2003 |
| Schneider-Lloyd International Retail Consultants Ltd. | Professional & scientific | 2015 |
| Scho Installations Ltd | Construction | 2024 |
| Schofield Hall Mortgage Brokers Ltd | Professional & scientific | 2001 |
| Scholar Saver Ltd | Information & communication | 2024 |
| Scholes Hall Management Company Limited | Households | 2004 |
| School Estates Thought Leaders Ltd | Administrative & support | 2025 |
| School House Nursery (NE) Limited | Health & social care | 2019 |
| School Improvement Liverpool Limited | Administrative & support | 2014 |
| School Lane Drinks Ltd | Hospitality | 2018 |
| School Lane Investments NW Ltd | Hospitality | 2017 |
| School of Popular Music UK Limited | Education | 2025 |
| School SCR Ltd | Information & communication | 2023 |
| School Wellbeing Accelerator Ltd | Information & communication | 2018 |
| School's Out.Com Limited | Education | 2002 |
| Schools HR and Employment Law Co-Operative Limited | Professional & scientific | 2012 |
| Schoot Limited | Education | 2021 |
| Schope Consultancy Ltd | Professional & scientific | 2025 |
| Schrodinger's Cat Media UK Ltd | Information & communication | 2022 |
| Schumann Enterprise Group Limited | Other services | 2016 |
| SCI Poma Limited | Real estate | 2015 |
| SCI Properties Limited | Real estate | 2013 |
| Scial Bsst Agncy Ltd | Professional & scientific | 2024 |
| Science of Sound CIC | Health & social care | 2022 |
| Science Technology Engineering Mathematics Club Ltd | Education | 2024 |
| Scientific Holdings Limited | Financial services | 2024 |
| Scimitar Transport LLP | | 2005 |
| Scintilla CME Ltd | Manufacturing | 2015 |
| Scintilla Links Limited | Administrative & support | 1985 |
| Sciontec Developments Limited | Real estate | 2018 |
| SCJ Properties Liverpool Limited | Real estate | 2021 |
| Scja Limited | Financial services | 2020 |
| Scjf Property Ltd | Real estate | 2024 |
| SCM Outsourcing Limited | Administrative & support | 2019 |
| SCM Properties 1 Ltd | Real estate | 2022 |
| SCM Rentals Limited | Real estate | 2021 |
| SCM Transport Services Limited | Transport & logistics | 2018 |
| SCN Roofing Limited | Construction | 2025 |
| SCO Property Group Ltd | Real estate | 2023 |
| Sconnors Ltd | Construction | 2026 |
| Scooby Blue NW Ltd | Professional & scientific | 2024 |
| Scoozi Aintree Limited | Hospitality | 2017 |
| Scoozi Ormskirk Limited | Hospitality | 2019 |
| Scope Personnel Holdings UK Ltd | Financial services | 2020 |
| Scope Personnel Limited | Administrative & support | 2015 |
| Scope Property Investment Ltd | Real estate | 2025 |
| SCOPE4 Developments Ltd | Construction | 2018 |
| Scorefluence Management Ltd | Information & communication | 2025 |
| Scorpio Lounge Ltd | Other services | 2020 |
| Scott Alexander Thomas Limited | Information & communication | 2016 |
| Scott Brewster Limited | Professional & scientific | 2011 |
| Scott Contractors Limited | Construction | 1997 |
| Scott Graham Ltd | Wholesale & retail | 2019 |
| Scott Investment & Securities Limited | Extraterritorial | 2021 |
| Scott R Young Services Ltd | Construction | 2025 |
| Scott Townsley Investments Ltd | Professional & scientific | 2026 |
| Scouse Competitions Ltd | Other services | 2021 |
| Scouse Roots CIC | Wholesale & retail | 2025 |
| Scouse Travel Ltd | Transport & logistics | 2024 |
| Scouse Triple Transport Ltd | Transport & logistics | 2025 |
| Scouse-Superstore Ltd | Wholesale & retail | 2021 |
| Scousemarket Limited | Information & communication | 2026 |
| Scout and Source Recruitment Ltd | Administrative & support | 2025 |
| Scpl HK Limited | Real estate | 2021 |
| Scpl International Limited | Real estate | 2022 |
| Scpl Property Limited | Real estate | 2022 |
| Scranary Cafe Limited | Hospitality | 2018 |
| Scrap Car Heaven Ltd | Wholesale & retail | 2016 |
| Scrap Tyre Solutions Ltd | Water & waste | 2026 |
| Scrapyard Studios CIC | Information & communication | 2018 |