| Enlight a Life Ltd | Wholesale & retail | 2021 |
| Enlight International Education Ltd | Education | 2014 |
| Ennea Health Limited | Health & social care | 2023 |
| Ennis Property Ventures Limited | Real estate | 2021 |
| Ennyjojo & Co Limited | Health & social care | 2017 |
| Enoch Electrical Ltd | Construction | 2026 |
| Enora Designer Boutique Ltd | Wholesale & retail | 2025 |
| Enova Solutions Limited | Energy | 2023 |
| Enrich Coaching Consultancy Limited | Administrative & support | 2019 |
| Enriched Spaces Ltd | Construction | 2025 |
| Enrique Sanchez Spanish Lawyers Ltd | Professional & scientific | 2012 |
| ENS Consulting Ltd | Information & communication | 2023 |
| Ensco 1150 Limited | Financial services | 2015 |
| Ensign Flag Co. Limited | Manufacturing | 1953 |
| Ensign Regalia Limited | Extraterritorial | 2003 |
| Entasia Music Ltd | Arts & recreation | 2026 |
| Enteral Access Technologies Ltd | Manufacturing | 2018 |
| Enterprise Blade Repair Services Ltd | Manufacturing | 2025 |
| Enterprise NW Services Ltd | Construction | 2017 |
| Entice Club Limited | Other services | 2026 |
| Entrust Professional Services Ltd | Professional & scientific | 2011 |
| Entwine Live (Club) Ltd | Arts & recreation | 2022 |
| Entwine Live (Festivals) Ltd | Arts & recreation | 2025 |
| Enviro Chill Ltd | Construction | 2013 |
| Enviro Clean Peterborough Ltd | Administrative & support | 2025 |
| Enviro Matters Ltd | Professional & scientific | 2025 |
| Enviro Path Waste Systems Limited | Water & waste | 2025 |
| Envirocleanlcr Ltd | Professional & scientific | 2025 |
| Environmental Asbestos Removals Ltd | Water & waste | 2021 |
| Envirope Ltd | Construction | 2024 |
| Envirosolution Limited | Other services | 2009 |
| Envirotec Solutions Holdings Limited | Financial services | 2022 |
| Envirotec Solutions Limited | Construction | 2022 |
| Envirotech (UK) Limited | Manufacturing | 1998 |
| Envisage Gardens by Design Ltd | Construction | 2016 |
| Envision NW Ltd | Administrative & support | 2025 |
| Envo Digital Ltd | Administrative & support | 2017 |
| Envogen Instrument Services Limited | Manufacturing | 1983 |
| Envogen M. and I. Ltd. | Professional & scientific | 2009 |
| Envogen U.K. Limited | Other services | 2002 |
| Enwright Holdings Ltd | Real estate | 2024 |
| Enxoo Limited | Information & communication | 2007 |
| Enya Holdings Limited | Financial services | 2002 |
| Enza Race Team & Logistics Ltd | Transport & logistics | 2023 |
| Enzo Consultancy Limited | Professional & scientific | 2025 |
| Enzo Moda Ltd | Wholesale & retail | 2024 |
| EO Creative Limited | Information & communication | 2023 |
| EO Sparkle Services Ltd | Administrative & support | 2026 |
| EOL Domestic Services Ltd | Administrative & support | 2006 |
| EOL Music Productions Limited | Information & communication | 2015 |
| EOP Properties Limited | Real estate | 2004 |
| EOS Bulk Limited | Transport & logistics | 2020 |
| EOS Engineering NW Ltd | Manufacturing | 2010 |
| EP Developments (NW) Limited | Real estate | 2025 |
| EP Property Management Ltd | Real estate | 2020 |
| EP Visual Ltd | Information & communication | 2025 |
| EPC Civil Engineering Limited | Construction | 2017 |
| EPC Liverpool Ltd | Professional & scientific | 2026 |
| EPC Northwest Ltd | Professional & scientific | 2022 |
| Epcm Professional Services Ltd | Administrative & support | 2017 |
| EPD Taxis Ltd | Transport & logistics | 2004 |
| Ephiny Ltd | Arts & recreation | 2025 |
| EPI North West Limited | Administrative & support | 2008 |
| Epic Agile UK Ltd | Professional & scientific | 2026 |
| Epic Home Collection Ltd | Wholesale & retail | 2025 |
| Epic Liverpool Limited | Hospitality | 2012 |
| Epic MBG Ltd | Real estate | 2016 |
| Epic Mobile Gaming Ltd | Arts & recreation | 2021 |
| Epic Nova Realm Ltd | Information & communication | 2025 |
| Epic Social Care C.I.C. | Health & social care | 2023 |
| Epica Environmental Limited | Professional & scientific | 2012 |
| Epica Health & Safety Limited | Professional & scientific | 2012 |
| Epica Health, Safety & Wellbeing Ltd | Administrative & support | 2019 |
| Epicerie Fine Limited | Hospitality | 2021 |
| Epiphany Bliss CIC | Other services | 2025 |
| Episode Properties Ltd | Hospitality | 2020 |
| Episteme Scientific Consulting Ltd | Professional & scientific | 2026 |
| Epizeuxis Ltd | Professional & scientific | 2014 |
| EPL Capital Limited | Financial services | 2017 |
| EPL Penny Lane Limited | Health & social care | 2025 |
| EPM Electrical Ltd | Professional & scientific | 2017 |
| EPM Technical Ltd | Construction | 2022 |
| EPO Performance Ltd | Wholesale & retail | 2022 |
| Epoch Engineering Limited | Manufacturing | 2025 |
| Epotech Limited | Hospitality | 1981 |
| EPR Consultants Ltd | Professional & scientific | 2025 |
| Epsilon Social Limited | Information & communication | 2025 |
| Epsilon Sport Services Ltd | Arts & recreation | 2026 |
| Epstein Court (Liverpool) Management Company Limited | Households | 1983 |
| Epstein Estates (Liverpool) Limited | Real estate | 2020 |
| Epstein Recruitment & Employment Ltd | Administrative & support | 2026 |
| Epsy Trading Ltd | Wholesale & retail | 2023 |
| Epuni Estates Ltd | Real estate | 2020 |
| EQ Electrical Ltd | Construction | 2021 |
| EQE Health Ltd | Health & social care | 2012 |
| EQU Ltd | Real estate | 2018 |
| Equal Vision Merseyside Community Interest Company | Health & social care | 2016 |
| Equality and Employment Law Centre Ltd. | Health & social care | 2003 |
| Equality Care NW Ltd | Health & social care | 2026 |
| Equation Financial Services Ltd | Financial services | 2008 |