| Emporia Marketing Ltd | Professional & scientific | 2021 |
| Emporium Collective Ltd | Hospitality | 2015 |
| Empower Accounting Ltd | Professional & scientific | 2023 |
| Empower Through Motion CIC | Education | 2025 |
| Empowered Consulting Services Ltd | Professional & scientific | 2023 |
| Empoweredfit Liverpool Ltd | Arts & recreation | 2024 |
| Empowering Wellbeing Limited | Education | 2024 |
| Empowher Womens Boxing Liverpool CIC | Arts & recreation | 2026 |
| Empra ELY Ltd | Manufacturing | 2022 |
| Empress HP Ltd | Other services | 2017 |
| Empress Letting Estates Ltd. | Real estate | 2012 |
| Empty Space Properties Ltd | Real estate | 2019 |
| Empyreal Candles Limited | Manufacturing | 2024 |
| EMR Cleaning Services Limited | Administrative & support | 2025 |
| EMR Columbus Quay Limited | Extraterritorial | 2012 |
| Emresibel Ltd | Arts & recreation | 2025 |
| Emro (SD) Ltd | Health & social care | 2020 |
| EMS Mortgages and Protection Ltd | Financial services | 2021 |
| EMS Repair Centre Ltd | Wholesale & retail | 2017 |
| Emsapphire Limited | Health & social care | 2025 |
| Emsoni Ltd | Wholesale & retail | 2024 |
| Emtech Group Ltd | Construction | 2023 |
| Emto Productions Ltd | Arts & recreation | 2024 |
| Emulsional Support Ltd | Construction | 2021 |
| ENA Sooknanan Trading Limited | Professional & scientific | 2017 |
| ENA Travels & Hire Ltd | Transport & logistics | 2025 |
| Enahouse Ltd | Real estate | 2023 |
| Enbild Limited | Wholesale & retail | 1967 |
| Enchanting Marketing Limited | Professional & scientific | 2012 |
| Encil Limited | Real estate | 1985 |
| Encore Retail Limited | Wholesale & retail | 1999 |
| Encrypted Fire & Security Ltd | Professional & scientific | 2025 |
| END Furniture Poverty Foundation | Health & social care | 2015 |
| END to END Limited | Professional & scientific | 2004 |
| Endale Energy Limited | Professional & scientific | 2020 |
| Endbutt Management Limited | Households | 1976 |
| Enddex Limited | Administrative & support | 2019 |
| Endeavour North Limited | Extraterritorial | 2010 |
| Endgame Studio Ltd | Information & communication | 2025 |
| Endless Opportunities.Care Limited | Health & social care | 2025 |
| Endless Sea Ltd | Wholesale & retail | 2023 |
| Endling Services Ltd | Other services | 2018 |
| Endmoore Properties Limited | Real estate | 2025 |
| Endopure Ltd | Other services | 2017 |
| Endopure Medical Limited | Manufacturing | 2006 |
| Endorsed Limited | Information & communication | 2026 |
| Endotone Ltd | Education | 2024 |
| Endurabox Ltd | Manufacturing | 2023 |
| Endurance Development Management Limited | Administrative & support | 2008 |
| Endurance Land (Farringdon) Limited | Construction | 2014 |
| Endurance Land (Northern) Limited | Construction | 2015 |
| Endurance Limited | Extraterritorial | 2008 |
| Endurance Properties Limited | Real estate | 2018 |
| Endurocide Limited | Extraterritorial | 2022 |
| Endymion Consulting Limited | Information & communication | 2023 |
| ENE Services Ltd | Wholesale & retail | 2021 |
| Energetic DEZ Ltd | Health & social care | 2021 |
| Energia (NW) Ltd | Energy | 2020 |
| Energite Ltd | Administrative & support | 2025 |
| Energiya Ltd | Other services | 2020 |
| Energize Electrical Services Limited | Construction | 2007 |
| Energizer Electrical Limited | Construction | 2019 |
| Energy Group Inc. Ltd | Construction | 2023 |
| Energycation Limited | Professional & scientific | 2022 |
| Energyprotech Limited | Professional & scientific | 2012 |
| Enervate Maintenance Ltd | Construction | 2021 |
| Enervate Property Group Ltd | Construction | 2020 |
| Enervate Renovations Ltd | Construction | 2021 |
| Enes Group Ltd | Financial services | 2023 |
| Eneso Trading Ltd | Wholesale & retail | 2021 |
| Enfield FC Football in the Community Ltd | Transport & logistics | 2005 |
| Enfield Football Club Football in the Community Ltd | Transport & logistics | 2005 |
| Engage Experts Limited | Information & communication | 2016 |
| Engage Liverpool CIC | Other services | 2012 |
| Engagewall Limited | Information & communication | 2018 |
| Engin NW Ltd | Construction | 2022 |
| Engine Room Gym Ltd | Arts & recreation | 2026 |
| Engineering and Mechanical Components Limited | Wholesale & retail | 1995 |
| Engineering Bureau Franke International Limited | Administrative & support | 2007 |
| Engineering Consulting Ltd | Professional & scientific | 2026 |
| Engineering Data Analytics Ltd | Information & communication | 2019 |
| Engineeringpmglobal Ltd | Professional & scientific | 2023 |
| Enginovate Ltd | Manufacturing | 2010 |
| English Provender Company Limited | Manufacturing | 1991 |
| English Schools' SKI Association Limited | Arts & recreation | 2012 |
| English Shop Property Limited | Extraterritorial | 2011 |
| English Village Homes Limited | Real estate | 2010 |
| English's Wreath Designs and More Ltd | Wholesale & retail | 2025 |
| Enhance Cleaning Ltd | Administrative & support | 2018 |
| Enhance Education Training Ltd | Education | 2021 |
| Enhance Partnership Limited | Education | 2020 |
| Enhance Window Cleaning Ltd | Administrative & support | 2021 |
| Enhanced Plumbing & Tiling Ltd | Construction | 2023 |
| Enhanced Security Services Ltd | Administrative & support | 2026 |
| Eniad Connects Services Ltd | Administrative & support | 2025 |
| Enigmayne Solutions Ltd | Transport & logistics | 2025 |
| Enjaz Holdings Ltd | Households | 2021 |
| Enjoy Nails Spa & Hair Salon Limited | Other services | 2025 |
| Enki Marine Ltd | Professional & scientific | 2022 |
| Enlai International Ltd | Administrative & support | 2021 |