| Snacc Ltd | Hospitality | 2022 |
| Snacky Bites Ltd | Hospitality | 2024 |
| Snake Newton Limited | Other services | 2021 |
| SNB AD Consultancy Services Ltd | Professional & scientific | 2024 |
| Snorer.Com Limited | Health & social care | 2012 |
| Snugglefoots Ltd | Manufacturing | 2025 |
| Snugstaff Ltd | Administrative & support | 2023 |
| SO Greedy Food Co Ltd | Hospitality | 2020 |
| SO Organic (UK) Limited | Wholesale & retail | 2008 |
| Sochar Prop Ltd | Real estate | 2019 |
| Social Care Strategies Limited | Professional & scientific | 2005 |
| Social Change Ltd | Information & communication | 2010 |
| Soclear Consulting Limited | Information & communication | 2019 |
| Sofone Ltd | Wholesale & retail | 2020 |
| Software and Integration Services Associates Limited | Information & communication | 2015 |
| Soggy Dogz Ltd | Arts & recreation | 2023 |
| Solamio Estates Limited | Real estate | 1989 |
| Solara Health Ltd | Health & social care | 2024 |
| Soldierboy Ltd | Wholesale & retail | 2026 |
| Solution Focused Psychology Ltd | Education | 2020 |
| Solutions and Beyond Limited | Information & communication | 2016 |
| Somayeh Expert Ltd | Extraterritorial | 2023 |
| Somers Bigsby Ltd | Financial services | 2023 |
| Somerton Meadows (Plots 53 and 54) Residents Management Company Limited | Real estate | 2016 |
| Sonic ROO Collective Ltd | Other services | 2025 |
| Sopart Ltd | Wholesale & retail | 2021 |
| Sorella Marketing Agency Limited | Professional & scientific | 2023 |
| Sorrento Bespoke Ltd | Real estate | 2022 |
| Sorrento Homes Ltd | Real estate | 2022 |
| Sosna Inc. Ltd | Information & communication | 2026 |
| Sota Living Ltd | Manufacturing | 2015 |
| Sothall Green Limited | Extraterritorial | 2025 |
| Sotm Clothing Limited | Wholesale & retail | 2025 |
| Soul Technology Limited | Information & communication | 2025 |
| Soundlincs | Arts & recreation | 1999 |
| Soundscription Limited | Manufacturing | 2019 |
| Sourcing Habitats Ltd | Real estate | 2019 |
| South East EYE Services Limited | Health & social care | 2006 |
| South East Urology Services Ltd | Extraterritorial | 2012 |
| South Hykeham Business Park Management Co Ltd | Real estate | 2025 |
| South Lincoln Healthcare Limited | Health & social care | 2015 |
| South Lincolnshire Crematorium Limited | Other services | 2012 |
| South London GI and Liver Clinics Ltd | Health & social care | 2012 |
| South Park Investments (Lincoln) Limited | Real estate | 2002 |
| South West ALP & Mentoring Limited | Arts & recreation | 2019 |
| South Yorkshire Fresh Produce and Flower Centre Management Company Limited | Administrative & support | 2000 |
| Southpark Letting Limited | Real estate | 2015 |
| Sova Transport Ltd | Transport & logistics | 2022 |
| Sovereign Estate Properties Ltd | Real estate | 2024 |
| Sovereign Lifestyle Music Limited | Arts & recreation | 1992 |
| Soyu Tech Ltd | Information & communication | 2025 |
| Spa Court (Woodhall) Management Company Limited | Households | 1988 |
| Spa Crop Consultants Limited | Professional & scientific | 1986 |
| Spa Theraplate Lincoln Ltd | Other services | 2025 |
| Spa Theraplate Wellness Clinics Ltd | Health & social care | 2025 |
| Space for Grace Limited | Agriculture & fishing | 2019 |
| Spalding Fasteners Limited | Wholesale & retail | 2018 |
| Spaldings Holdings Limited | Agriculture & fishing | 2003 |
| Spaldings Limited | Agriculture & fishing | 1981 |
| Spaniel Inns Holdings Limited | Hospitality | 2021 |
| Spaniel Properties Limited | Real estate | 2021 |
| Sparkle Entertainment Limited | Arts & recreation | 2009 |
| Sparklinc Clean Ltd | Administrative & support | 2022 |
| Sparkly Clean by Sarah Ltd | Administrative & support | 2025 |
| Sparks Electrical Installations Limited | Construction | 2011 |
| Sparrow Homes Ltd | Construction | 2016 |
| Sparta Care Ltd | Construction | 2024 |
| Sparta Heating Ltd | Construction | 2021 |
| Spartan Analytics Ltd. | Information & communication | 2022 |
| SPE International Limited | Manufacturing | 1983 |
| Spec & FIX Locking Solutions Limited | Other services | 2022 |
| Specialist Anaesthesia Limited | Health & social care | 2019 |
| Specialist Heat Exchangers Limited | Manufacturing | 1968 |
| Specialist Psychology Services Limited | Health & social care | 2010 |
| Specialist Surface Solutions Ltd | Construction | 2014 |
| Specialist Water Technologies Limited | Administrative & support | 2017 |
| Speeder Property Ltd | Real estate | 2022 |
| Speedframe (Lincoln) Limited | Wholesale & retail | 2002 |
| Spence Accounting Limited | Professional & scientific | 2009 |
| Spencer-Mills Developments Limited | Real estate | 2016 |
| Spericle Ltd | Real estate | 2008 |
| SPG Logistics Limited | Transport & logistics | 2017 |
| SPH Fire Safety Limited | Professional & scientific | 2016 |
| Sphinx SCT Ltd | Other services | 2021 |
| Spicer Investments Ltd | Health & social care | 2025 |
| Spikomat Limited | Wholesale & retail | 1998 |
| Spilsby Garage Limited | Wholesale & retail | 2020 |
| Spineworks Limited | Health & social care | 2000 |
| Spiranto Limited | Information & communication | 2014 |
| Spires Solutions Limited | Professional & scientific | 2021 |
| Splashscreen Limited | Information & communication | 2019 |
| Split Infinitive Ltd | Arts & recreation | 2019 |
| Spooner Transport Ltd | Transport & logistics | 2022 |
| Sportreel Ltd | Wholesale & retail | 2017 |
| Sports & Leisure Brands Ltd | Wholesale & retail | 2004 |
| Sports Clinical Ltd | Health & social care | 2021 |
| Sports Therapy 2 YOU Ltd | Health & social care | 2017 |
| Sports Therapy Association | Other services | 2015 |
| Spotless & Sparkle Cleaning Services Ltd | Administrative & support | 2025 |
| Spotless Cleaning (Lincs) Limited | Administrative & support | 1999 |