| Severn Communications Limited | Professional & scientific | 2005 |
| Sexton Belle Ltd | Real estate | 2021 |
| SF Forever Homes C.I.C. | Public administration | 2021 |
| SF Smith Mechanical Repairs Ltd | Wholesale & retail | 2015 |
| Sflichfield Ltd | Education | 2024 |
| SG Legacy Ltd | Financial services | 2026 |
| SGP Sorting UK Ltd | Wholesale & retail | 2012 |
| Sguk Enterprises Limited | Other services | 2019 |
| Sguk Estates Limited | Real estate | 2021 |
| SH Hospitality Limited | Hospitality | 2009 |
| Shadow Gaming Limited | Extraterritorial | 2021 |
| Shadow Sports Limited | Arts & recreation | 2019 |
| Shanknight Group Ltd | Financial services | 2024 |
| Shark Holdings Ltd | Financial services | 2016 |
| Sharp Home Improvements Limited | Construction | 2006 |
| Sharp Supply Ltd | Wholesale & retail | 2025 |
| Shaw Estate Management 2 Limited | Real estate | 2023 |
| Shaw Estate Management Limited | Real estate | 2015 |
| Shawbury Wine Limited | Wholesale & retail | 2015 |
| SHE IS Jewellery Ltd | Wholesale & retail | 2026 |
| SHE Says Consulting Ltd | Professional & scientific | 2026 |
| Sheepwash Farm Day Nursery Limited | Education | 2020 |
| Sheepwash Farm Renewables Limited | Energy | 2012 |
| Sheepwash Machinery Hire Ltd | Administrative & support | 2025 |
| Shenaha Limited | Hospitality | 2022 |
| Shendor Limited | Administrative & support | 2006 |
| Shenstone Commodities Limited | Wholesale & retail | 1978 |
| Shenstone Construction Ltd | Construction | 2023 |
| Shenstone Financial Services Ltd | Professional & scientific | 2010 |
| Shenstone Group Limited | Financial services | 1997 |
| Shenstone Hall Ltd | Administrative & support | 2016 |
| Shenstone Properties Limited | Real estate | 1986 |
| Shenstone Property Ltd | Construction | 2025 |
| Shenstone Stores T/A Village Stores Ltd | Wholesale & retail | 2019 |
| Shenstone Timber Preservation Ltd. | Wholesale & retail | 1969 |
| Shepherd Properties Ltd | Real estate | 2023 |
| Shepherds Farm Management Company Limited | Households | 2026 |
| Sheppard and Sheppard Ltd | Real estate | 2022 |
| Sheriffs Ride Management Company Limited | Households | 2004 |
| Sherwood Hall Associates Ltd | Professional & scientific | 1998 |
| Shft Media Limited | Information & communication | 2025 |
| Shivalika Properties Limited | Real estate | 2017 |
| SHO Supply Limited | Other services | 2025 |
| Shokar Property Limited | Real estate | 2021 |
| Short and Curly's Coffee Ltd | Hospitality | 2024 |
| Shoshin.Co.Shop Limited | Information & communication | 2024 |
| Shropshire Building Company Ltd | Construction | 2020 |
| Shumary Estates Ltd | Real estate | 2025 |
| Siam Corner Express Ltd | Hospitality | 2024 |
| Siam Corner Mama Thai Ltd | Hospitality | 2021 |
| SIB Group Ltd | Manufacturing | 2012 |
| Sidney Goodman Properties Limited | Real estate | 2016 |
| Silhill Taverns (Brewcity Lichfield) Ltd | Manufacturing | 2025 |
| Silica Properties Limited | Real estate | 2018 |
| Silkcroft Limited | Agriculture & fishing | 2018 |
| Silver Blades Ice Rink Company (Altrincham) Limited | Arts & recreation | 2006 |
| Silver Blades Ice Rink Company (Cannock) Limited | Extraterritorial | 2006 |
| Silver Blades Ice Rink Company (Gillingham) Ltd. | Arts & recreation | 2008 |
| Silver Blades Ice Rink Company (Leeds) Limited | Arts & recreation | 2014 |
| Silver Blades Ice Rink Company (Solihull) Limited | Arts & recreation | 2015 |
| Silver Blades Ice Rink Company (Widnes) Limited | Arts & recreation | 2012 |
| Silver Stingray Limited | Hospitality | 2017 |
| Silverface Ltd | Other services | 2020 |
| SIM Holdings Limited | Real estate | 2025 |
| SIM Mayou Hardware Limited | Wholesale & retail | 2024 |
| SIM Mayou Properties Limited | Real estate | 2023 |
| Simbadaktari Locum Services Ltd | Professional & scientific | 2015 |
| Simon Bridgens Engineering Limited | Real estate | 1979 |
| Simon Chan IT Ltd | Information & communication | 2016 |
| Simon Johnson Limited | Other services | 2014 |
| Simplicate Consulting Limited | Professional & scientific | 2016 |
| Simply Trading Forex Limited | Education | 2008 |
| Simpson Waste Services Limited | Water & waste | 2025 |
| Simtra Global Ltd | Professional & scientific | 2024 |
| Sinclair Computer Limited | Information & communication | 2014 |
| Sinclair Thomson Building & Project Consultancy Limited | Professional & scientific | 2020 |
| Sinead Mccann Aesthetics Ltd | Other services | 2026 |
| Sing N JAM Ltd | Education | 2019 |
| Sirag Tours Limited | Administrative & support | 2018 |
| Sisu Therapy Limited | Health & social care | 2016 |
| Sitefortyfive Ltd | Real estate | 2021 |
| SJ Healthcare Ltd | Health & social care | 2025 |
| SJM Fire Protection Services Limited | Public administration | 2025 |
| Sjmb Investments Ltd | Real estate | 2015 |
| SJP Lichfield Limited | Other services | 2017 |
| Skarn Associates Limited | Professional & scientific | 2016 |
| Skarn Water Limited | Professional & scientific | 2023 |
| Skatterbox Ltd | Professional & scientific | 2009 |
| Skin Essential Lichfield Ltd | Other services | 2025 |
| Skipp Properties Limited | Real estate | 2023 |
| SKK Interiors Ltd | Administrative & support | 2023 |
| Skye Holiday Rentals Ltd | Real estate | 2016 |
| SL & Co Solicitors Limited | Professional & scientific | 2005 |
| Sleepless Knights Games Ltd | Information & communication | 2025 |
| Slicz Golf Ltd | Manufacturing | 2023 |
| SM Holdings SPV Limited | Financial services | 2025 |
| Smart Accountants Limited | Professional & scientific | 2000 |
| Smart Entertainment Limited | Information & communication | 1998 |
| Smart Image (Shenstone) Limited | Manufacturing | 2005 |
| Smart Online Accountants Ltd | Professional & scientific | 2013 |