| S & J Wilkins Limited | Professional & scientific | 2008 |
| S & O Investments Limited | Real estate | 2014 |
| S & T Potatoes Limited | Wholesale & retail | 2003 |
| S Currie TM Ltd | Construction | 2024 |
| S E Controls Limited | Extraterritorial | 1988 |
| S J Beddoe Ltd | Construction | 2013 |
| S L Brickwork Limited | Construction | 2013 |
| S R P Contracts Limited | Construction | 2006 |
| S Rajkumar Limited | Health & social care | 2012 |
| S Saunders Quantity Surveying Ltd | Professional & scientific | 2014 |
| S T Renovations Ltd | Real estate | 2019 |
| S&S Architecture (Ashby) Limited | Professional & scientific | 2018 |
| S&S Architecture (UK) Limited | Professional & scientific | 2018 |
| S&S Architecture Limited | Professional & scientific | 2003 |
| S.A.I. Automotive Telford Limited | | 1987 |
| S.A.I. Emirates Limited | Real estate | 2020 |
| S.A.P Detailing Ltd | Administrative & support | 2024 |
| S.A.S Developments (Midlands) Limited | Real estate | 2025 |
| S.C.C. Electrical & Security Limited | Construction | 2005 |
| S.D.T.M Limited | Other services | 2013 |
| S.J.S. Interior Solutions Limited | Construction | 2006 |
| S.T.Surveys Ltd. | Financial services | 2015 |
| S.W. Johnson (Electrical) Limited | Construction | 2001 |
| S33MA B Ltd | Real estate | 2024 |
| S4 Swim (Franchising) Limited | Professional & scientific | 2013 |
| S4 Swim School Limited | Education | 2010 |
| Sacred SZN Limited | Wholesale & retail | 2025 |
| SAD Dog Films Limited | Information & communication | 2024 |
| Sade Developments Ltd | Real estate | 2023 |
| Safe Hands Finance Ltd | Professional & scientific | 2025 |
| Safe Spaces Therapy Ltd | Health & social care | 2021 |
| Safety on Track Limited | Information & communication | 2017 |
| SAI Automotive Washington Limited | Manufacturing | 1989 |
| Saigon Nails (Lichfield) Ltd | Other services | 2011 |
| Salon ENV Limited | Other services | 2007 |
| SAM Asghar Ltd | Wholesale & retail | 2019 |
| Samani Healthcare Limited | Health & social care | 2025 |
| Sambenellie Ltd | Real estate | 2025 |
| Sambrooke Park (Potters Bar) Management Company Limited | Households | 2025 |
| Samcro Solutions Limited | Professional & scientific | 2017 |
| Samuel Bailey Ltd | Wholesale & retail | 2024 |
| SAN Barbers Ltd | Other services | 2026 |
| Sanctuary Garden Rooms Limited | Construction | 2025 |
| Sanders Electrical Services Midlands Limited | Construction | 2025 |
| Sanders Fire & Compliance Ltd | Construction | 2024 |
| Sandhawalia Farm Ltd | Agriculture & fishing | 2024 |
| Sandringham House Management Ltd | Real estate | 2022 |
| Sands Media Associates Limited | Information & communication | 2010 |
| Santa and Friends Limited | Wholesale & retail | 2013 |
| Sapentia Limited | Information & communication | 2023 |
| Sapphire 22 Limited | Financial services | 2022 |
| SAR House Limited | Real estate | 2019 |
| Sarah Lowe Cosmetic Tattoo Specialist Ltd | Other services | 2026 |
| Saraswati Solutions Ltd | Professional & scientific | 2024 |
| Sass London Ltd | Administrative & support | 2018 |
| Savannah International Ltd | Information & communication | 2019 |
| Saxtons Vegetables Limited | Other services | 1996 |
| SB Legacy Property Ltd | Real estate | 2025 |
| SC Bartter Gardening & Waste Removal Ltd. | Water & waste | 2019 |
| Scabdym Ltd | Transport & logistics | 2019 |
| SCAN2SMILES Ltd | Health & social care | 2026 |
| Scelta Solutions Ltd | Professional & scientific | 2020 |
| SCH Solutions and Consultancy Ltd | Professional & scientific | 2021 |
| Scholar Construction Limited | Construction | 2004 |
| School Access Transport Ltd | Transport & logistics | 2025 |
| School Appeals (West Midlands) Limited | Education | 2014 |
| Screedspec Ltd | Wholesale & retail | 2017 |
| Screeduct Ltd | Construction | 1990 |
| Scribes Kitchens Limited | Construction | 2018 |
| SCS Property Holdings Ltd | Real estate | 2020 |
| SCW Electrical Limited | Construction | 2005 |
| SD Software Limited | Information & communication | 2025 |
| Sdginvest Limited | Administrative & support | 2020 |
| SE Controls Group Limited | Financial services | 2006 |
| Sea Change Therapy & Coaching Limited | Other services | 2025 |
| Sean Clair Limited | Information & communication | 2025 |
| Searchco Limited | Administrative & support | 2017 |
| Seasons Group Ltd | Manufacturing | 2024 |
| Seaxe Limited | Professional & scientific | 2002 |
| Sebar Holding Ltd | Financial services | 2022 |
| Sebastopol Publishing Limited | Information & communication | 2011 |
| Sebonig Properties Limited | Real estate | 2006 |
| Secure Hosting Limited | Extraterritorial | 1998 |
| Secure PAY Limited | Professional & scientific | 1999 |
| Seldom Ltd | Real estate | 2017 |
| Select Energy Group Ltd | Wholesale & retail | 2015 |
| Select Group Capital Holdings Ltd | Financial services | 2020 |
| Selectequip Holdings Limited | Financial services | 2016 |
| Selectequip Limited | Wholesale & retail | 1989 |
| Selfless Films Limited | Information & communication | 2021 |
| Septico Organic Products Limited | Manufacturing | 1989 |
| Septimus Spyder Soft Drinks Limited | Manufacturing | 1995 |
| Seren Agency Limited | Other services | 2025 |
| Serenity Beauty Salon Shenstone Ltd | Other services | 2018 |
| Service Garage (Borrowash) Ltd | Financial services | 2021 |
| Service Garage Limited | Wholesale & retail | 1990 |
| Settel Ltd | Information & communication | 2025 |
| Seven Care Services Ltd | Health & social care | 2021 |
| Seven Childrens Homes Limited | Health & social care | 2023 |
| Severn Communications Holdings Limited | Professional & scientific | 2005 |