| DEO Property Limited | Real estate | 2014 |
| Deploy Link Limited | Administrative & support | 2026 |
| Derdateam Limited | Real estate | 2024 |
| Design & Control (Lighting) Ltd | Professional & scientific | 2011 |
| Design Command Limited | Professional & scientific | 2013 |
| Design Investments Limited | Professional & scientific | 2015 |
| Design Your Recline Ltd | Wholesale & retail | 2023 |
| Detailing Law Ltd | Other services | 2015 |
| DG Cleaners UK Ltd | Administrative & support | 2024 |
| DH Holdings Limited | Financial services | 2022 |
| DHH Garden Services Ltd | Administrative & support | 2015 |
| Diamiqe Financial Services Ltd | Other services | 2006 |
| Diamond Documentation Limited | Information & communication | 2017 |
| Diamond Wheels Ltd | Wholesale & retail | 2025 |
| Diara Properties Ltd | Real estate | 2023 |
| Didsbury House Ltd | Construction | 2020 |
| Digipoint Ltd | Information & communication | 2017 |
| Digisquad Consulting Limited | Information & communication | 2022 |
| Digitimer Holdings Limited | Financial services | 2022 |
| Digitimer Limited | Manufacturing | 1948 |
| Dilpreet Brickwork Ltd | Construction | 2011 |
| Discovering DNA Ltd | Professional & scientific | 2013 |
| Ditch's Driving School Limited | Education | 2026 |
| Ditcham Consulting Ltd | Professional & scientific | 2019 |
| Diva Jeans Ltd | Manufacturing | 2016 |
| DK Cleancare Ltd | Administrative & support | 2026 |
| DKH Underfloor Heating Consultants Ltd | Construction | 2007 |
| DKO Risk Management Limited | Information & communication | 2017 |
| DKS Legal Services Limited | Professional & scientific | 2024 |
| DM Calibration Group Limited | Administrative & support | 2024 |
| DM Calibration Limited | Administrative & support | 1991 |
| DM Systems Group Limited | Professional & scientific | 2010 |
| DM the Carpet Cleaners Ltd | Administrative & support | 2025 |
| DND Exterior Cleaning Limited | Administrative & support | 2026 |
| DNK Bros Ltd | Manufacturing | 2022 |
| DNK Properties and Investment Ltd | Financial services | 2023 |
| DNP Holdings Limited | Financial services | 2026 |
| Dodotraders UK Limited | Wholesale & retail | 2012 |
| Doek and Slay UK Ltd | Arts & recreation | 2025 |
| Dominion City Hatfield Ltd | Other services | 2025 |
| Double M Promotions Limited | Administrative & support | 2025 |
| Dovedale Farms Limited | Agriculture & fishing | 2010 |
| Dprc Trucking (UK) Ltd | Transport & logistics | 2013 |
| DR Felicity Wallace Services Ltd | Education | 2020 |
| Dragon Chinese Restaurant Ltd | Hospitality | 2020 |
| Drain Call Services Limited | Other services | 2001 |
| Drax (UK) Limited | Administrative & support | 2001 |
| Drax Services (UK) Ltd | Construction | 2014 |
| DRAX360 Limited | Construction | 2014 |
| DRB Building Limited | Construction | 2021 |
| Dream Stayz Ltd | Hospitality | 2023 |
| Drink on Ltd | Manufacturing | 2023 |
| DS2BUILDINGSOLUTION Ltd | Construction | 2025 |
| Dtech (Hitchin) Limited | Professional & scientific | 2006 |
| Dunhams Lane Limited | Real estate | 2017 |
| Duocor Limited | Health & social care | 2017 |
| Durachem Ltd | Wholesale & retail | 2008 |
| Duryard Ltd | Real estate | 2023 |
| DVB Tyre Recycling Limited | Water & waste | 2013 |
| E F Groundworks & Construction Ltd | Construction | 2022 |
| E W Flooring Specialists Ltd | Construction | 2022 |
| E&E Accounting and Tax Services Ltd | Professional & scientific | 2022 |
| Early Bird Pre-School CIC | Education | 2016 |
| East END Farm Eggs Ltd | Agriculture & fishing | 2020 |
| East Manufacturing Technologies Limited | Manufacturing | 1999 |
| Eastcheap Barbers Ltd | Other services | 2019 |
| Eastcheap Space CIC | Arts & recreation | 2022 |
| Eastons Boots Ltd | Hospitality | 2015 |
| Easysteame Ltd | Wholesale & retail | 2025 |
| Eazycraft Limited | Transport & logistics | 2001 |
| Eazytec Precision Limited | Manufacturing | 2006 |
| EC Resourcing Limited | Administrative & support | 2011 |
| Ecotyre Services Limited | Wholesale & retail | 2020 |
| ECS Global Europe Ltd | Information & communication | 1993 |
| ECS Global Group Ltd | Professional & scientific | 1996 |
| Eden Cosmetics Ltd | Wholesale & retail | 2021 |
| Eden Generation Ltd | Construction | 2021 |
| Eden Sustainable Growth Investments 1 Ltd | Professional & scientific | 2024 |
| Eden Sustainable Growth Ltd | Professional & scientific | 2024 |
| Eden Sustainable Investments 10 Ltd | Professional & scientific | 2023 |
| Eden Sustainable Investments 8 Ltd | Energy | 2018 |
| Eden Sustainable Investments Holdco Ltd | Financial services | 2018 |
| Eden Sustainable Ltd | Professional & scientific | 2014 |
| Edge IT Consulting Limited | Information & communication | 2012 |
| Edge Utility Networks Limited | Energy | 2024 |
| Edmonds Powder Coating Ltd | Professional & scientific | 2015 |
| Effexio Ltd | Professional & scientific | 2021 |
| Egri Maintenance Ltd | Construction | 2007 |
| EJF Town Planning Limited | Professional & scientific | 2022 |
| Ekdp Limited | Professional & scientific | 2018 |
| Ekdp Properties Ltd | Real estate | 2022 |
| El-Desire Investments and Properties Ltd | Real estate | 2021 |
| Elecology Limited | Construction | 2010 |
| Electrassure Limited | Construction | 2004 |
| Electronic Call Handling Operations Limited | Information & communication | 2017 |
| Electronic Waste Recycling Ltd | Wholesale & retail | 2005 |
| Elitco Ltd | Construction | 2012 |
| Elixier Consulting Limited | Professional & scientific | 2009 |
| Ellicott Productions Ltd | Construction | 2017 |
| Emans HCM Ltd | Information & communication | 2025 |