| CTM Flooring Ltd | Construction | 2022 |
| Cube (Leigh) Ltd | Wholesale & retail | 2025 |
| Cubecraft Ltd | Information & communication | 2024 |
| Cunninghams Bathrooms Ltd | Construction | 2020 |
| Cupid's Health Club Limited | Arts & recreation | 2020 |
| Cuppa Coffee Club Limited | Hospitality | 2026 |
| Custom Shuttering and Logistic Solutions Ltd | Construction | 2024 |
| CVS Hvac Services Limited | Construction | 2020 |
| Cyaneus Consultancy Ltd | Professional & scientific | 2025 |
| Cyptour Ltd | Information & communication | 2025 |
| D & E Joinery Limited | Manufacturing | 2019 |
| D Greenwood Investments Ltd | Administrative & support | 2016 |
| D J Pilling & SON LLP | | 2016 |
| D L Plumbing (NW) Ltd | Wholesale & retail | 2008 |
| D R C Plant Engineering Ltd | Manufacturing | 2020 |
| D&M Whitelion Ltd | Hospitality | 2025 |
| D'Luxe Solution Ltd | Administrative & support | 2025 |
| D. Holt Flooring Contractors Limited | Construction | 1999 |
| D2R Property Management Ltd | Real estate | 2025 |
| DAC Interiors & Refurbishment Limited | Construction | 2012 |
| Daida Limited | Information & communication | 2022 |
| Dainsmith & Co. Limited | Construction | 1982 |
| Daintith Transport Limited | Transport & logistics | 2017 |
| Dakore Media Limited | Information & communication | 2025 |
| Damp Shield Solutions Limited | Construction | 2025 |
| Danfield Limited | Manufacturing | 1965 |
| Darby Dog Kennels Ltd | Professional & scientific | 1998 |
| Dark ELF INK Ltd | Arts & recreation | 2019 |
| Darren J Photography Limited | Professional & scientific | 2019 |
| Darwen Holdings Ltd | Financial services | 2024 |
| Datametriks Ltd | Information & communication | 2022 |
| David Ormerod Limited | Real estate | 1999 |
| Davidolf Trans Ltd | Construction | 2026 |
| Davinci Services Ltd | Construction | 2021 |
| Dawn Fencing Limited | Construction | 1984 |
| Dawsons Bakers and Confectioners Ltd | Wholesale & retail | 2019 |
| Dawsons Leigh Ltd | Wholesale & retail | 2019 |
| Daylight Counselling Limited | Health & social care | 2005 |
| DCB (Waterside) Ltd | Hospitality | 2025 |
| DDG Heating & Plumbing Limited | Construction | 2006 |
| Ddll Leisure Ltd | Real estate | 2025 |
| Ddrive Ltd | Education | 2023 |
| DE Cedar Health Ltd | Health & social care | 2025 |
| Deans Retail Ltd | Wholesale & retail | 2019 |
| Decoredge Limited | Professional & scientific | 2004 |
| Deehaven Properties Ltd | Real estate | 2025 |
| Degrees & Medals Limited | Professional & scientific | 2025 |
| DEL X Limited | Construction | 2022 |
| Deli Boys Limited | Hospitality | 2013 |
| Delta Access Limited | Construction | 2019 |
| Delta Engineering Services Limited | Construction | 2026 |
| Delta Trader Ltd | Wholesale & retail | 2026 |
| Deluxus Ltd | Wholesale & retail | 2023 |
| Deng Transport Ltd | Transport & logistics | 2023 |
| Dentdale Developments Limited | Construction | 2018 |
| Derek's Rugs Ltd | Wholesale & retail | 2024 |
| Designer Wetrooms Limited | Wholesale & retail | 2012 |
| DF Agriservice Ltd | Manufacturing | 2019 |
| DG Conservatories and Windows Limited | Construction | 2013 |
| DG Engineering and Fabrication Services Ltd | Professional & scientific | 2024 |
| DI Transport Ltd | Transport & logistics | 2017 |
| Diamond Hart Limited | Information & communication | 2019 |
| Difr Ecom Limited | Wholesale & retail | 2023 |
| Digital Marketing Focus Ltd | Information & communication | 2009 |
| Dillan's Deli & Sandwich Bar Ltd | Hospitality | 2025 |
| Dina Chicken Ltd | Hospitality | 2021 |
| Direct Ecommerce Ltd | Wholesale & retail | 2020 |
| Direct Response Services (NW) Ltd | Other services | 2007 |
| Direct Solutions Plumbing Ltd | Construction | 2021 |
| Disability Transport Services Ltd | Transport & logistics | 2023 |
| Divine Amazing Joy & Favour Ltd | Administrative & support | 2020 |
| Divo Logistics Ltd | Transport & logistics | 2019 |
| Divvy in a Bivvy Ltd | Manufacturing | 2026 |
| DJ Couriers Ltd | Transport & logistics | 2017 |
| Djidjor Ltd | Wholesale & retail | 2024 |
| DJM Engineering (NW) Limited | Professional & scientific | 2022 |
| DJS Heating Limited | Construction | 2017 |
| DLM Textiles Ltd | Wholesale & retail | 2025 |
| DM Spraying Services Ltd | Wholesale & retail | 2018 |
| DMA Amour Limited | Wholesale & retail | 2025 |
| DMG Autos & Recovery Ltd | Wholesale & retail | 2021 |
| DMG Bricklaying Ltd | Construction | 2018 |
| DML Electrical Services Ltd | Manufacturing | 2014 |
| DMP Plumbing & Heating Service Limited | Construction | 2023 |
| DMR Training & Consultancy Limited | Professional & scientific | 2013 |
| Dojo Lettings Ltd | Real estate | 2025 |
| Dolled UP Beauty Bar Ltd | Other services | 2020 |
| Dols BIA Limited | Health & social care | 2015 |
| Dolsuk Limited | Health & social care | 2015 |
| DON Alberto's Leigh Ltd | Hospitality | 2022 |
| Don'T Diet Club Ltd | Hospitality | 2016 |
| Done Dealz Services Limited | Transport & logistics | 2025 |
| Dootsons Law Limited | Professional & scientific | 2015 |
| Doplagos Limited | Arts & recreation | 2025 |
| Double Best Creation Ltd | Construction | 2022 |
| Double Check Digital Engineering Ltd | Professional & scientific | 2022 |
| Double DMS (UK) Limited | Households | 2023 |
| Doublet Consulting Ltd | Professional & scientific | 2026 |
| Dovedale Property Management Limited | Real estate | 2005 |
| Down to Earth Groundwork Limited | Administrative & support | 2015 |