| SD Vehicles Ltd | Wholesale & retail | 2021 |
| SD12 Ltd | Professional & scientific | 2019 |
| SDC Construction (Midlands) Limited | Construction | 2021 |
| SDC Securities (Leicester) Limited | Real estate | 1999 |
| SDC1 Projects Ltd | Construction | 2021 |
| SDD Couriers Ltd | Transport & logistics | 2018 |
| SDD Group Limited | Transport & logistics | 2018 |
| Sddm Projects Ltd | Real estate | 2024 |
| SDL Elevation Limited | Administrative & support | 2025 |
| SDL Express Limited | Wholesale & retail | 2026 |
| SDM Care Limited | Health & social care | 2015 |
| SDR Building and Maintenance Ltd | Construction | 2024 |
| SDR Corporation Limited | Professional & scientific | 2022 |
| SDR Events Limited | Wholesale & retail | 2022 |
| SDR Investor Limited | Real estate | 2025 |
| SDR Pharma Limited | Wholesale & retail | 2015 |
| Sdrn Properties Ltd | Real estate | 2023 |
| SDS Brickwork Ltd | Construction | 2021 |
| Sdsa Foundation | Education | 2011 |
| Sdsa Leicester | Education | 2011 |
| SE8 Developments Ltd | Construction | 2025 |
| Sea Land Enterprise Ltd | Wholesale & retail | 2022 |
| Sea Never DRY Limited | Transport & logistics | 2025 |
| Sea Pantry Limited | Hospitality | 2025 |
| Seabrook Digital Solutions Limited | Professional & scientific | 2008 |
| Seafood Centre Leicester Ltd | Wholesale & retail | 2020 |
| Seagrave Nurseries Ltd | Wholesale & retail | 2009 |
| Seagrave Park Residents Management Company Limited | Households | 2023 |
| Seagull Ship Services Limited | Wholesale & retail | 2020 |
| Seagull Transport Ltd | Transport & logistics | 2024 |
| Seaheights Ltd | Real estate | 2025 |
| Seal Consulting Limited | Professional & scientific | 2023 |
| Seal Property Assets Limited | Real estate | 2023 |
| Seal Rental LLP | | 2022 |
| Sealgrove Trustees Limited | Professional & scientific | 1979 |
| Seamless Guttering Limited | Construction | 2024 |
| Seamona Property Investment Ltd | Real estate | 2024 |
| Sean & Sons Trading Ltd | Administrative & support | 2024 |
| Sean Davis Ltd | Education | 2015 |
| Sean Mary Ltd | Wholesale & retail | 2024 |
| Seaquest Trading Ltd | Wholesale & retail | 2026 |
| Search Cloud Ltd | Real estate | 2017 |
| Search&Buy Ltd | Wholesale & retail | 2025 |
| SEARCH4ENERGY Ltd | Energy | 2015 |
| Searchtal Recruitment Limited | Wholesale & retail | 2016 |
| Searlcon Limited | Construction | 2025 |
| Seasay Ltd | Real estate | 2018 |
| Season and More Ltd | Wholesale & retail | 2023 |
| Seasonal Home Solutions Limited | Manufacturing | 2024 |
| Seasonal Investments Ltd | Real estate | 2020 |
| Seasonal Leicester Ltd | Wholesale & retail | 2016 |
| Seasonal Superbooze Ltd | Wholesale & retail | 2017 |
| Seasons Beauty Salon & Day Spa Limited | Other services | 2003 |
| Seasons Supplies Limited | Wholesale & retail | 2023 |
| Seaton Family Limited | Health & social care | 2023 |
| Seaton Investments Limited | Real estate | 2003 |
| Seaton Roswell Ltd | Wholesale & retail | 2025 |
| Seaweed Wonderland Ltd | Wholesale & retail | 2020 |
| Seawind Solution Ltd | Information & communication | 2016 |
| Seaworld Ltd | Wholesale & retail | 2017 |
| SEB Construction Ltd | Construction | 2019 |
| SEB Courier Ltd | Transport & logistics | 2018 |
| Sebastian Kraft Consulting Limited | Professional & scientific | 2020 |
| Sebastian Pawlaczek Ltd | Wholesale & retail | 2014 |
| Sebi&Deni Limited | Transport & logistics | 2026 |
| Seby UK Removals Ltd | Transport & logistics | 2016 |
| Secel Ltd | Wholesale & retail | 2026 |
| Secklow Properties Limited | Construction | 2000 |
| Second Gears Trading Ltd | Professional & scientific | 2025 |
| Second Generation (2000) Limited | Administrative & support | 1988 |
| Second Nature Gardens Limited | Construction | 2013 |
| Second Property Ltd | Real estate | 2020 |
| Second Time Around CIC | Wholesale & retail | 2022 |
| Secret of Eden Ltd | Hospitality | 2024 |
| Section SIX Ltd | Wholesale & retail | 2018 |
| Sector Refit & Refurbishment Limited | Construction | 2020 |
| Secure Homes (Leicester) Ltd | Construction | 2021 |
| Secure I Ltd | Construction | 2019 |
| Secure Key Property Ltd | Real estate | 2023 |
| Secure One Holdings Limited | Construction | 2008 |
| Secure Payment Platform Ltd | Administrative & support | 2025 |
| Secure Property Leasing Ltd | Real estate | 2026 |
| Secure Security & Services Ltd | Construction | 2020 |
| Secure Shredding Solutions Ltd | Administrative & support | 2018 |
| Secure Social Housing Ltd | Real estate | 2020 |
| Secure Trade Windows & Doors Ltd | Construction | 2011 |
| Secure Zonee Ltd | Wholesale & retail | 2025 |
| Secure-It (Leicester) Limited | Manufacturing | 2004 |
| Secured Quantum Services Europe Ltd | Professional & scientific | 2025 |
| Securesecuritysolutionsuk Ltd | Administrative & support | 2023 |
| Securesmart Solutions Ltd | Administrative & support | 2023 |
| Securitransform IT Consulting Ltd | Information & communication | 2023 |
| Security & Risk Management Services Ltd | Administrative & support | 2024 |
| Security Studio Limited | Administrative & support | 2025 |
| Seddons Industrial Heritage Limited | Manufacturing | 2015 |
| SEE YOU Songs Limited | Information & communication | 2021 |
| SEE Your Baby Limited | Health & social care | 2018 |
| See.K Design Services Ltd | Professional & scientific | 2022 |
| Seeb's International Atmosphere Ltd | Wholesale & retail | 2026 |
| Seed Properties Ltd | Real estate | 2016 |