| Scapers Limited | Transport & logistics | 2019 |
| Scar Therapy Network Limited | Public administration | 2025 |
| Scarcroft Logistics Ltd | Transport & logistics | 2014 |
| Scarfo Ltd | Wholesale & retail | 2024 |
| Scarlett and Wildflowers Limited | Wholesale & retail | 2024 |
| Scarlett Grace Ltd | Other services | 2019 |
| SCD Bird Ltd | Professional & scientific | 2019 |
| Scene Music Group Ltd | Hospitality | 2025 |
| Scenex Property Limited | Real estate | 2012 |
| Scenex Sets and Staging Ltd | Manufacturing | 2000 |
| Scent 3 Ltd | Wholesale & retail | 2025 |
| Scent Select Ltd | Wholesale & retail | 2026 |
| Scentech Ltd | Wholesale & retail | 2025 |
| Scented Ecom Limited | Wholesale & retail | 2025 |
| Scented Gardens by Vision Limited | Wholesale & retail | 2024 |
| Scented GEM Limited | Other services | 2022 |
| Scented Vibez Limited | Wholesale & retail | 2025 |
| SCF Western Limited | Professional & scientific | 2012 |
| SCG Transport Ltd | Transport & logistics | 2016 |
| SCH Machinery Trading LLP | | 2013 |
| Schlegel Automotive Europe Limited | Manufacturing | 1999 |
| Schmunny Limited | Professional & scientific | 2024 |
| Scholar's View (Leicester) Management Company Limited | Households | 2002 |
| Scholarino Ltd | Education | 2025 |
| Scholars Academy Trust | Education | 2013 |
| Scholars Court Management Limited | Real estate | 2006 |
| School Improvement Service Ltd | Education | 2022 |
| School of Art, Commerce & Technology Limited | Education | 2020 |
| School Runs Group Limited | Transport & logistics | 2023 |
| Schoolsplusuk Ltd | Information & communication | 2019 |
| Schulz Coaching Academy Limited | Arts & recreation | 2020 |
| Schulz Elite Performance Centre Limited | Education | 2022 |
| Schulz Events Limited | Administrative & support | 2023 |
| SCI Consultants Ltd | Professional & scientific | 2025 |
| SCI ED Consult Ltd | Education | 2019 |
| SCI Group Ltd | Construction | 2021 |
| SCI Properties Group Ltd | Households | 2024 |
| Sci-Sport Limited | Manufacturing | 1989 |
| Scicomm Solutions Ltd | Administrative & support | 2022 |
| Science of MAN International Ltd | Administrative & support | 2016 |
| Sciers Ltd | Transport & logistics | 2019 |
| Scimedex Limited | Wholesale & retail | 2016 |
| SCJ16 Limited | Administrative & support | 2020 |
| SCL Sheetmetal Limited | Manufacturing | 2026 |
| Scl-Contracts and Building Limited | Construction | 2025 |
| SCM Auto Group Ltd | Transport & logistics | 2024 |
| SCM Electrical Services Limited | Construction | 2013 |
| SCN24 Ltd | Wholesale & retail | 2024 |
| Scomed Ltd | Professional & scientific | 2018 |
| Sconversions Ltd | Professional & scientific | 2026 |
| Scoops Cozak Ltd | Wholesale & retail | 2026 |
| Scope Electrical Ltd | Construction | 2021 |
| Scope Homes and Property Limited | Real estate | 2025 |
| Scope Training Ltd | Education | 2022 |
| Scopic Research Limited | Financial services | 2009 |
| Scorpion Properties Ltd | Financial services | 2013 |
| Scorpion Security Global Ltd | Administrative & support | 2021 |
| Scorpvirgo Ltd | Real estate | 2023 |
| Scotia Press Limited | Manufacturing | 1998 |
| Scotia Press UK Limited | Manufacturing | 2018 |
| Scott Bailye Hairdressing Limited | Other services | 2009 |
| Scott Choucino Limited | Professional & scientific | 2026 |
| Scott Couriers Limited | Transport & logistics | 2024 |
| Scott H Limited | Construction | 2007 |
| Scott Lapidge Photography Ltd | Professional & scientific | 2020 |
| Scott Locums Ltd | Health & social care | 2018 |
| Scott Lyons Lettings Limited | Real estate | 2026 |
| Scott Lyons Property Limited | Administrative & support | 2025 |
| Scott Mcquillan Limited | Construction | 2026 |
| Scott Swift Limited | Professional & scientific | 2003 |
| Scott Water Services Limited | Professional & scientific | 2020 |
| Scott Watson Builders Limited | Construction | 2014 |
| Scottie Contract Cleaning Ltd | Administrative & support | 2023 |
| Scovos Limited | Wholesale & retail | 2021 |
| Scpa Solutions Limited | Professional & scientific | 2025 |
| Scrambled Data Ltd | Information & communication | 2019 |
| Scrap&Waste Ltd | Water & waste | 2020 |
| Scraptoft Lane Store Ltd | Wholesale & retail | 2022 |
| Scratch-Technology Ltd | Professional & scientific | 2012 |
| Screen Print Supply Ltd | Administrative & support | 2009 |
| Script-Link Limited | Administrative & support | 2026 |
| Scripti Limited | Administrative & support | 2009 |
| Scrivens Safety Solutions Ltd | Health & social care | 2020 |
| Scroll Bidco Limited | Information & communication | 2025 |
| Scrubs Cleaning Services Ltd | Administrative & support | 2025 |
| SCT Admin Services Limited | Administrative & support | 2025 |
| Scube Digital Limited | Information & communication | 2013 |
| Scudamore Motors Ltd | Wholesale & retail | 2020 |
| Sculpt & Form Ltd | Arts & recreation | 2025 |
| Sculptaé Ltd | Other services | 2021 |
| Sculpti Ltd | Information & communication | 2025 |
| Sculptia Limited | Administrative & support | 2009 |
| SD Construction Leicester Ltd | Construction | 2023 |
| SD Housing Ltd | Real estate | 2025 |
| SD Hub Ltd | Wholesale & retail | 2025 |
| SD Impact Venture Limited | Professional & scientific | 2024 |
| SD Medics Ltd | Health & social care | 2021 |
| SD Store Ltd | Wholesale & retail | 2026 |
| SD Studio Ltd | Professional & scientific | 2009 |
| SD Translate UK Limited | Professional & scientific | 2022 |