| Enjely Limited | Wholesale & retail | 2025 |
| Enjoy Transport Ltd | Transport & logistics | 2021 |
| Enjoyment.Managers.Entertainment Ltd | Hospitality | 2024 |
| Enlightened Care Generation Limited | Health & social care | 2018 |
| Enlightenment Press Limited | Information & communication | 2009 |
| Enliven Group Ltd | Administrative & support | 2025 |
| Enliven Properties Ltd | Real estate | 2025 |
| Enliven Social Care Limited | Health & social care | 2021 |
| Ennjay Care Limited | Administrative & support | 2023 |
| Ennoor Limited | Health & social care | 2025 |
| Ennovus Solutions Limited | Administrative & support | 2015 |
| Enny-Thing Ltd | Information & communication | 2024 |
| ENO Tiling Ltd | Construction | 2025 |
| Enough Stores Retail Ltd | Wholesale & retail | 2021 |
| Enough Technologies Ltd | Information & communication | 2024 |
| Enquire-It UK Ltd | Information & communication | 2016 |
| Enrj Consulting Limited | Professional & scientific | 2012 |
| Ensco 536 Limited | Real estate | 2006 |
| Ensor Consultancy Ltd | Information & communication | 2021 |
| Enstruct Training Ltd | Education | 2011 |
| Ensuremysmile Ltd | Health & social care | 2024 |
| Ensygn Limited | Manufacturing | 2010 |
| ENT Tutoring Ltd | Education | 2019 |
| Enter Edem Ltd | Professional & scientific | 2013 |
| Entera Medical Ltd | Wholesale & retail | 2020 |
| Enterprise Graphics Limited | Manufacturing | 1976 |
| Entertee Limited | Administrative & support | 1998 |
| Enthuse International Limited | Professional & scientific | 2005 |
| Enthuse Limited | Administrative & support | 2005 |
| Entiiro Ltd | Professional & scientific | 2026 |
| Entire Recycling Limited | Wholesale & retail | 2011 |
| Entire Urban Ltd | Wholesale & retail | 2024 |
| Entrad Financial Services Limited | Other services | 2016 |
| Entriga Ltd | Professional & scientific | 2016 |
| Entropy Laboratories Limited | Professional & scientific | 2023 |
| Enve Online Solutions Ltd | Wholesale & retail | 2023 |
| Envee Properties Limited | Real estate | 2019 |
| Enveh Transport & Logistics Limited | Wholesale & retail | 2024 |
| Enver Karadayi Ltd | Hospitality | 2012 |
| Envergure Limited | Real estate | 2019 |
| Enviro Volumetric Mixers Ltd | Manufacturing | 2022 |
| Enviro-Hygiene Ltd | Professional & scientific | 2010 |
| Enviroduct Limited | Construction | 2010 |
| Enviroera Ltd | Wholesale & retail | 2025 |
| Environmental Engineering Designs Limited | Construction | 2018 |
| Environtec Group Limited | Professional & scientific | 2018 |
| Environtec Limited | Professional & scientific | 1994 |
| Envisage Digital Limited | Wholesale & retail | 2016 |
| Envision Coachworks Ltd | Manufacturing | 2024 |
| Envision Concepts Limited | Information & communication | 2004 |
| Envision Property Limited | Real estate | 2021 |
| Envision TCI Ltd | Information & communication | 2024 |
| Envoria Ltd | Real estate | 2016 |
| Envy Innovations Limited | Manufacturing | 2019 |
| Envy POS Limited | Manufacturing | 2015 |
| Envy Retail Limited | Manufacturing | 2018 |
| Enzo Interiors Ltd | Manufacturing | 2025 |
| EP Business Growth Services Ltd | Administrative & support | 2024 |
| EP Cleaning Services Ltd | Administrative & support | 2026 |
| EP Property Services Ltd | Real estate | 2023 |
| EPA Talent Ltd | Arts & recreation | 2025 |
| Epaccsys Development Ltd | Real estate | 2004 |
| Epaccsys Ltd | Information & communication | 2001 |
| Epdl Ltd | Manufacturing | 2025 |
| Epeeple Limited | Real estate | 2008 |
| EPG Property Ltd | Construction | 2019 |
| Ephphatha Consulting Ltd | Health & social care | 2025 |
| Ephrathah Ltd | Health & social care | 2026 |
| Epic Build Limited | Construction | 2019 |
| Epic Equality Ltd | Professional & scientific | 2023 |
| Epic Merchants Limited | Construction | 2024 |
| Epic Music Events Ltd | Arts & recreation | 2014 |
| Epic Rally Limited | Administrative & support | 2019 |
| Epignosys Limited | Professional & scientific | 2010 |
| Epik Brands Ltd | Wholesale & retail | 2022 |
| Epileum Property Limited | Construction | 2020 |
| Epilith Limited | Information & communication | 2019 |
| Epower Ebikes UK Ltd | Manufacturing | 2022 |
| EPR Properties Ltd | Real estate | 2013 |
| EPR Repairs Ltd | Construction | 2025 |
| EPS Event Limited | Administrative & support | 2016 |
| Epsilon Electrical Holdings Limited | Financial services | 2025 |
| Epsilon Electrical Limited | Construction | 2010 |
| Epuffer Limited | Wholesale & retail | 2016 |
| Epworth Court Management Company Ltd | Households | 2006 |
| EQ Planning Ltd | Administrative & support | 2024 |
| EQ Wealth Management Limited | Financial services | 2018 |
| Equaa Ltd | Manufacturing | 2025 |
| Equal Margins Limited | Professional & scientific | 2026 |
| EQUARIO8 Limited | Professional & scientific | 2020 |
| Equestrian Living Global Limited | Real estate | 2006 |
| Equifyve Limited | Financial services | 2020 |
| Equipe Solutions Ltd | Information & communication | 2016 |
| Equipment Leasing Solutions Limited | Financial services | 2014 |
| Equira Ltd | Manufacturing | 2026 |
| Equisol UK Limited | Wholesale & retail | 2008 |
| Equity A.I. Limited | Information & communication | 2019 |
| Equity Consultants (Leicester) Limited | Professional & scientific | 2003 |
| Equity Energies Limited | Professional & scientific | 2016 |
| Equityguru Ltd | Real estate | 2021 |