| Chimichecas Limited | Manufacturing | 2025 |
| Chnt Ltd | Real estate | 2025 |
| Christopher Taylor Design Limited | Professional & scientific | 1988 |
| Churnet Valley Books Limited | Wholesale & retail | 2002 |
| Churnet Valley Garden Furniture Ltd | Manufacturing | 2017 |
| Churnet Valley Limited | Construction | 2002 |
| Churnet Valley Precision Engineering Ltd | Manufacturing | 2014 |
| Churnetsoundradio Community Interest Company | Information & communication | 2021 |
| Ciseo Limited | Professional & scientific | 2023 |
| Citadel U.K. Limited | Construction | 2002 |
| Clay Projects Limited | Construction | 2008 |
| Claycast Developments Ltd | Real estate | 2025 |
| Clewlow Electrical Limited | Construction | 2003 |
| Clifford Green Electrical Limited | Construction | 2000 |
| Clyb Design Ltd | Construction | 2023 |
| CMT Joinery Ltd | Construction | 2024 |
| CMX Holdings Limited | Financial services | 2026 |
| Cofam Limited | Wholesale & retail | 2025 |
| Coffee Beans Cafe Limited | Hospitality | 1988 |
| Coffee Beans Leek Ltd | Hospitality | 2025 |
| Cogress Keston Limited | Financial services | 2015 |
| Collision Course Limited | Hospitality | 2024 |
| Colshaw Structures Ltd | Construction | 2024 |
| Companion for Care Services Limited | Health & social care | 2018 |
| Compression Ignition Power Solutions Ltd. | Manufacturing | 2017 |
| CON VIT Software Ltd | Information & communication | 2024 |
| Connectlink Limited | Wholesale & retail | 1999 |
| Consall Valley Leisure Limited | Hospitality | 2019 |
| Container Storage Leek Ltd | Other services | 2025 |
| Controlled Hydraulic Movement Limited | Construction | 1999 |
| Cooper & SON Farm Machinery Ltd | Wholesale & retail | 2025 |
| Corble Group Limited | Financial services | 2013 |
| Corlyn Calibration Limited | Administrative & support | 2025 |
| Cornerstone Developments (Staffs) Ltd | Real estate | 2023 |
| Cornerstone Developments Leek Ltd | Real estate | 2017 |
| CRD Communications Ltd | Administrative & support | 2014 |
| Creative Wooden Structures Ltd | Construction | 2019 |
| Credible Clothing Ltd | Wholesale & retail | 2021 |
| Crewe Ultra Ltd | Hospitality | 2025 |
| Critical Security Solutions Limited | Construction | 2014 |
| CS Plastering and Rendering Services Limited | Construction | 2021 |
| CSF Commercials Limited | Wholesale & retail | 2007 |
| Culinary Care Limited | Hospitality | 2024 |
| Curious Badger Limited | Information & communication | 2014 |
| Curry Spice (Leek) Ltd | Hospitality | 2025 |
| Curtis Rivers Coaching Limited | Education | 2024 |
| Custom Products Europe Limited | Administrative & support | 2014 |
| Cv-Abas Limited | Professional & scientific | 2012 |
| Cyberline Distribution Limited | Wholesale & retail | 2025 |
| Cycle Frames Ltd. | Administrative & support | 2018 |
| D & D UK Courier Ltd | Transport & logistics | 2016 |
| D & T Food Services Limited | Hospitality | 2021 |
| D a Smith Groundworks Ltd | Agriculture & fishing | 2019 |
| D Metcalfe Ltd | Construction | 2025 |
| D&Bpipestands Ltd | Manufacturing | 2019 |
| D. Lear Haulage Limited | Transport & logistics | 2005 |
| D2H Limited | Professional & scientific | 2008 |
| D7 Dreams Ltd | Real estate | 2023 |
| Daisylaneco Limited | Wholesale & retail | 2026 |
| Dale Electrical & Security Ltd | Construction | 2015 |
| DAN Massey Joinery Ltd | Construction | 2023 |
| Daniel & Hulme (Leek) Ltd | Real estate | 2023 |
| Daniel Hyde Financial Services Ltd | Financial services | 2017 |
| DAP Squared Ltd | Manufacturing | 2012 |
| Data Logic Solutions Limited | Information & communication | 2025 |
| Davem Plant Limited | | 1966 |
| DB Properties (Staffordshire) Ltd | Real estate | 2022 |
| DB Services (Staffordshire) Ltd | Construction | 2015 |
| DBD Architectural Consultancy Ltd | Professional & scientific | 2014 |
| Ddqi Ltd | Construction | 2020 |
| Ddsr Limited | Administrative & support | 2025 |
| Dear Barber Ltd | Wholesale & retail | 1984 |
| Deebank Developments Ltd. | Construction | 2016 |
| Deebank Heights Management Company Limited | Households | 2017 |
| Delinquent&Co Ltd | Wholesale & retail | 2022 |
| Delta Force Cleaning & Hygiene Ltd | Administrative & support | 2026 |
| Delta Force Fire & Security Ltd | Administrative & support | 2025 |
| Delta Force Landscaping & Ground Maintenance Ltd | Administrative & support | 2025 |
| Delta Force Ltd | Administrative & support | 2025 |
| Delta Force Security Ltd | Administrative & support | 2024 |
| Denby Campervans Limited | Administrative & support | 2008 |
| Denise White Estate Agents Buxton Ltd | Real estate | 2026 |
| Denise White Estate Agents Limited | Real estate | 2017 |
| Derek Mawby Paving Limited | Construction | 1999 |
| Design Solutions Interiors Limited | Construction | 2012 |
| Designed Architecture Solutions Limited | Professional & scientific | 2023 |
| Devilformetal Records Ltd | Wholesale & retail | 2018 |
| DFK Properties Ltd | Households | 2026 |
| DG Investments (Staffordshire) Ltd | Real estate | 2021 |
| Direct Synergy LLP | | 2021 |
| DIY Conservatories Ltd | Professional & scientific | 2011 |
| Dj&R Ltd | Hospitality | 2026 |
| DLH Taverns Limited | Hospitality | 2025 |
| DN Building Services Ltd | Construction | 2026 |
| Docksey Transport Holdings Limited | Financial services | 2018 |
| Dog Dayzz Ltd | Agriculture & fishing | 2024 |
| Dog Training Revolution Ltd | Education | 2024 |
| Dornlie Limited | Health & social care | 2013 |
| Dove Valley Investments Limited | Real estate | 1999 |
| Dream Business Dream Life Consulting Ltd | Other services | 2024 |