| Scorpio Products International Limited | Real estate | 2019 |
| Scorpion 311 Ltd | Construction | 2025 |
| Scot Ross Consultancy Ltd | Administrative & support | 2016 |
| Scotchie's Caribbean Cuisine Ltd | Wholesale & retail | 2019 |
| Scotfield Group Limited | Real estate | 1989 |
| Scotgate Development Limited | Wholesale & retail | 1990 |
| Scothaul Ltd | Transport & logistics | 2025 |
| Scotnest Property Group Ltd | Real estate | 2025 |
| Scots Group Ltd | Wholesale & retail | 2026 |
| Scotscraig Consultancy Limited | Professional & scientific | 2016 |
| Scott & James Limited | Manufacturing | 2017 |
| Scott & Mears Credit Services Limited | Financial services | 2005 |
| Scott Brothers Enterprises Limited | Manufacturing | 2009 |
| Scott Copley Estate Agents Limited | Real estate | 2024 |
| Scott Cricket Bats Limited | Manufacturing | 2021 |
| Scott Custom Ltd | Manufacturing | 2011 |
| Scott Dickson Ltd | Manufacturing | 2025 |
| Scott Electrical (Leeds) Ltd | Construction | 2016 |
| Scott Johnson Personal Training Limited | Arts & recreation | 2024 |
| Scott Properties (YKS) Ltd | Real estate | 2026 |
| Scott Sparrow Limited | Wholesale & retail | 2017 |
| Scott Waldron Groundworks Limited | Construction | 2023 |
| Scott's Building Co. Limited | Construction | 2025 |
| Scott's of Leeds Ltd | Wholesale & retail | 2017 |
| Scottbar Limited | Construction | 2007 |
| Scotthall & Chapeltown Aikido Limited | Arts & recreation | 2017 |
| Scotthall Gents Barber Ltd | Other services | 2023 |
| Scotts of Leeds Service and MOT Limited | Wholesale & retail | 2021 |
| Scotts Property Management Ltd | Real estate | 2020 |
| Scottsdale Properties Limited | Real estate | 2017 |
| Scottyp Projects Ltd | Construction | 2020 |
| Scotwood Global Ltd | Professional & scientific | 2020 |
| Scout Tech Ltd | Information & communication | 2025 |
| Scoutport Ltd | Real estate | 2024 |
| SCP Developments Limited | Construction | 2023 |
| Scratch and Newton Ltd | Wholesale & retail | 2011 |
| Scratching Shed Publishing Limited | Information & communication | 2008 |
| Scrawny Badger Ltd | Information & communication | 2022 |
| Screen Activation Ltd | Administrative & support | 2019 |
| Screen Dummies Limited | Wholesale & retail | 2024 |
| Screen Yorkshire Limited | Information & communication | 2002 |
| Screen-O-Rama Ltd | Wholesale & retail | 2014 |
| SCREEN4 (Yorkshire) Limited | Transport & logistics | 2019 |
| Screenhouse Productions Limited | Information & communication | 1991 |
| Screenie Limited | Wholesale & retail | 2025 |
| Screening Solutions Ltd | Administrative & support | 2020 |
| Screenjam Ltd | Manufacturing | 2025 |
| Scribedge Ltd | Other services | 2025 |
| Script OQ Ltd | Information & communication | 2020 |
| Script Yorkshire Limited | Arts & recreation | 1997 |
| Scruffy D Broadcast Services Limited | Information & communication | 2007 |
| Scrum Cubs Ltd | Arts & recreation | 2026 |
| Scuderia (Gosforth) Limited | Real estate | 2016 |
| Scullonix Limited | Information & communication | 2013 |
| Scully Michele Ltd | Hospitality | 2026 |
| Sculpt Aura Ltd | Health & social care | 2024 |
| Sculpt Digital Limited | Information & communication | 2017 |
| Sculpt Medical Aesthetics Ltd | Other services | 2022 |
| Sculpt Spmu Academy Ltd | Other services | 2025 |
| Sculpt Spmu Ltd | Arts & recreation | 2025 |
| Sculptured Elegance (Leeds) Limited | Construction | 2004 |
| SD Bango Property Investments Limited | Real estate | 2023 |
| SD Couriers (NE) Ltd | Transport & logistics | 2018 |
| SD Global Ltd | Wholesale & retail | 2026 |
| SD Media Productions Ltd | Information & communication | 2025 |
| SD Trading Leeds Limited | Wholesale & retail | 2014 |
| SDA Architects Limited | Professional & scientific | 1997 |
| SDA Partnership Limited | Professional & scientific | 1994 |
| SDA Trustees Limited | Administrative & support | 2024 |
| Sdar Properties Ltd | Real estate | 2024 |
| SDB Tyre Services Limited | Wholesale & retail | 2019 |
| Sdbpatel Ltd | Health & social care | 2022 |
| SDC Yorkshire Ltd | Construction | 2020 |
| Sdds Consulting Limited | Information & communication | 2006 |
| Sderio Ltd | Information & communication | 2019 |
| Sdet Digital Ltd | Information & communication | 2018 |
| SDF Diagnostic Imaging Ltd | Other services | 2025 |
| SDG (Glossop) Limited | Construction | 2010 |
| SDG (Newport) Limited | Construction | 2010 |
| SDG (Wigan) Limited | Construction | 2010 |
| SDG Edinburgh Ltd | Real estate | 2022 |
| SDG Home & Property Maintenance Limited | Construction | 2023 |
| SDH Installs Limited | Construction | 2021 |
| SDK Property Limited | Real estate | 2018 |
| SDK Roofing Ltd | Construction | 2015 |
| SDL Ceramics Limited | Construction | 2012 |
| SDL Groundworks Ltd | Construction | 2026 |
| SDM Signs & Graphics Ltd | Construction | 2019 |
| Sdmt Limited | Information & communication | 2010 |
| Sdna Properties Ltd | Real estate | 2017 |
| SDP Laboratory Limited | Health & social care | 2011 |
| SDS Medical Services Ltd | Health & social care | 2015 |
| SDS RT Ltd | Professional & scientific | 2024 |
| SE Environmental Ltd | Financial services | 2022 |
| SE Investment Properties (UK) Ltd | Real estate | 2025 |
| SE Realisations Limited | Information & communication | 2018 |
| SE Search Ltd | Administrative & support | 2023 |
| Sea & Speed Ltd | Wholesale & retail | 2023 |
| Sea Pearl Yacht Recruitment Ltd | Administrative & support | 2026 |
| SEA2SKI Travel Ltd | Administrative & support | 2023 |