| Scarborough Brunswick Limited | Real estate | 2021 |
| Scarborough Business Park Management Company Limited | Households | 2007 |
| Scarborough China Holdings Limited | Financial services | 2003 |
| Scarborough DC Limited | Real estate | 2012 |
| Scarborough Development Group Limited | Financial services | 2010 |
| Scarborough Development Services Limited | Construction | 2010 |
| Scarborough Energy Limited | Mining & quarrying | 2022 |
| Scarborough Fish (Wholesale) Limited | Wholesale & retail | 1978 |
| Scarborough GF Limited | Real estate | 2014 |
| Scarborough Group Limited | Financial services | 2004 |
| Scarborough International Properties Limited | Real estate | 2014 |
| Scarborough Legacy Holdings Limited | Construction | 2021 |
| Scarborough Management Limited | Professional & scientific | 2011 |
| Scarborough Mscp B3 Limited | Construction | 2020 |
| Scarborough Overseas Holdings Limited | Financial services | 2011 |
| Scarborough Partnership Limited | Professional & scientific | 2010 |
| Scarborough Partnership Residential Limited | Real estate | 2007 |
| Scarborough Premier Developments Limited | Financial services | 2011 |
| Scarborough Shellfish Limited | Wholesale & retail | 2017 |
| Scarborough Thorpe Park Holdings Limited | Financial services | 2015 |
| Scarborough United Group Limited | Financial services | 2000 |
| Scarcroft Court Management Company Limited | Households | 1983 |
| Scarcroft Crescent Management Company Limited | Households | 2023 |
| Scarcroft Estates Limited | Construction | 2016 |
| Scarcroft Golf Club Limited | Arts & recreation | 1957 |
| Scarcroft Home Developments Limited | Construction | 2021 |
| Scarcroft Loft Conversions Ltd | Construction | 2023 |
| Scarflace Ltd | Manufacturing | 1997 |
| Scargill Legal Services Limited | Professional & scientific | 2021 |
| Scarlet Cleaning Limited | Administrative & support | 2005 |
| Scarlett Homes Limited | Arts & recreation | 2006 |
| Scarlett Living Limited | Real estate | 2022 |
| Scarlett Pellam Ltd | Arts & recreation | 2025 |
| Scarlett Property Services Limited | Administrative & support | 2016 |
| Scarmac Limited | Financial services | 2000 |
| Scarsgarth Properties Ltd | Real estate | 2020 |
| Scarth Risk Management Ltd | Financial services | 2014 |
| Scarths Decorating Ltd | Construction | 2019 |
| Scarves Direct Ltd | Wholesale & retail | 2020 |
| Scatco Europa Limited | Manufacturing | 1977 |
| Scattergood & Johnson Limited | Wholesale & retail | 1924 |
| Scaunlocked Limited | Education | 2025 |
| SCB Properties Limited | Real estate | 2019 |
| SCC Education Ltd | Education | 2024 |
| SCC Leeds Limited | Wholesale & retail | 2015 |
| SCC Worldwide Limited | Wholesale & retail | 1987 |
| Sccb Properties Limited | Real estate | 2021 |
| SCD Construction Limited | Extraterritorial | 2008 |
| SCD Group Limited | Construction | 1997 |
| SCD Networks Limited | Information & communication | 2002 |
| Scenic Landscapers Limited | Administrative & support | 2005 |
| Scent Salim Bradford Ltd | Wholesale & retail | 2025 |
| SCF Property Management Ltd | Real estate | 2023 |
| SCH Legal Ltd | Professional & scientific | 2022 |
| Sch-Computing Ltd | Information & communication | 2014 |
| Schal International Management Limited | Administrative & support | 1991 |
| Schanez Ltd | Administrative & support | 2022 |
| Schefer Interim & Consulting Limited | Professional & scientific | 2021 |
| Scheme Underwriting (U.K.) Limited | Professional & scientific | 1982 |
| Schiadas Homes Ltd. | Administrative & support | 2019 |
| Schmutter Limited | Manufacturing | 2021 |
| Schofield Contracting Ltd | Construction | 1995 |
| Schofield Insurance Brokers Limited | Financial services | 2003 |
| Schofield Leeds Holdings Limited | Real estate | 2025 |
| Schofield Leeds Limited | Real estate | 2025 |
| Scholara Limited | Administrative & support | 2025 |
| Scholefield Estates Limited | Construction | 2015 |
| Scholes Daycare Limited | Health & social care | 2024 |
| Scholes Development Company Limited | Real estate | 1993 |
| Scholes Park Developments Limited | Real estate | 1999 |
| School Lane Limited | Real estate | 2022 |
| School LN Investments Limited | Financial services | 2024 |
| Schoolgle Limited | Information & communication | 2025 |
| Schools UK Protection Limited | Administrative & support | 2021 |
| Schooner Seafoods (Processing) Limited | Manufacturing | 1985 |
| Schur Flexible UK Ltd | Manufacturing | 1985 |
| Sci-Po Ltd | Extraterritorial | 2011 |
| Sci-Rec Ltd | Professional & scientific | 2023 |
| Science Communication Ltd | Information & communication | 2016 |
| Science Faraway Tech Ltd | Professional & scientific | 2024 |
| Science for Sport Limited | Education | 2018 |
| Science Supermarket Limited | Professional & scientific | 2016 |
| Scientific Games UK Acquisitions Ltd | Financial services | 2021 |
| Scilja Limited | Real estate | 2017 |
| Scin Aesthetics Limited | Health & social care | 2023 |
| Scintillate UP Ltd | Wholesale & retail | 2021 |
| Scissorhands Barber Ltd | Other services | 2023 |
| Scitech Solutions Ltd | Wholesale & retail | 2013 |
| SCJ Seligmann Limited | Health & social care | 2025 |
| Scjb Construction Ltd | Construction | 2026 |
| SCL Security Ltd | Education | 2009 |
| Sclim Surgical Ltd | Health & social care | 2022 |
| SCM Installations Ltd | Construction | 2019 |
| SCN Holidays Ltd | Transport & logistics | 2020 |
| SCO 174 Consulting Limited | Financial services | 2006 |
| Scobie (Llarn) Limited | Wholesale & retail | 1984 |
| Scoops and Sips Ltd | Hospitality | 2025 |
| Scopeos Limited | Information & communication | 2025 |
| Scoremore Limited | Education | 2024 |
| Scorpio Print Finishers Limited | | 2006 |