| Denflav Clean Ltd | Administrative & support | 2024 |
| Dengenzii UK Ltd | Real estate | 2020 |
| Dengenzy UK Limited | Real estate | 2012 |
| Dengo Media Limited | Professional & scientific | 2016 |
| Denia Property 2000 Limited | Real estate | 2001 |
| Deniro Fast Food Ltd | Hospitality | 2017 |
| Denis Concept Ltd | Construction | 2022 |
| Denis GANGAL20 Ltd Ltd | Transport & logistics | 2026 |
| Denises Dancewear Ltd | Wholesale & retail | 2010 |
| Denison Hall Limited | Households | 2005 |
| Denison Investments Ltd | Construction | 2025 |
| Denison Mayes Group Limited | Manufacturing | 1998 |
| Denlab Ltd | Construction | 2024 |
| Dennet Ltd | Hospitality | 2018 |
| Dennis Construct Ltd | Administrative & support | 2025 |
| Denphil Ltd | Administrative & support | 2013 |
| Dental Drop Shop Limited | Wholesale & retail | 2026 |
| Dental Mavericks | Health & social care | 2011 |
| Dentcore Ltd | Administrative & support | 2023 |
| Dentcraft Dental Laboratory Limited | Manufacturing | 2002 |
| Denton Park Ltd | Extraterritorial | 2005 |
| Dentozen Leeds Ltd | Health & social care | 2023 |
| Dentsecure Ltd | Health & social care | 2022 |
| Dentzilla Limited | Wholesale & retail | 2018 |
| Denworthy Ltd | Construction | 2005 |
| Denzel Power - Cabling & Energy Services Ltd | Construction | 2022 |
| Deodats Ltd | Wholesale & retail | 2026 |
| Deols Convenience Stores Ltd | Information & communication | 2017 |
| DEP GAS Services Ltd | Other services | 2015 |
| Departure Events Limited | Arts & recreation | 2025 |
| Dependable Trading Ltd | Wholesale & retail | 2012 |
| Depho Estates Limited | Real estate | 2004 |
| Deploypro Limited | Information & communication | 2023 |
| Deposit Guard Ltd | Information & communication | 2025 |
| Depuy Synthes (UK) Limited | Manufacturing | 2026 |
| Deqq Ltd | Information & communication | 2026 |
| Dera Carriage Ltd | Transport & logistics | 2019 |
| Derby Energy Limited | Construction | 2024 |
| Derby Pads Ltd | Real estate | 2023 |
| Derekbuilding Limited Enterprise Ltd | Construction | 2025 |
| Derett Ltd | Extraterritorial | 2022 |
| Derin Transparts Ltd | Transport & logistics | 2025 |
| Deritend International Limited | Manufacturing | 1948 |
| Derived Power Ltd | Water & waste | 2019 |
| Derma Distribution Ltd | Wholesale & retail | 2018 |
| Derma Glow Wellness & Medical Aesthetics Ltd | Administrative & support | 2025 |
| Derma Hubb Clinic Ltd | Health & social care | 2024 |
| Derma LAB Harrogate Ltd | Other services | 2024 |
| Derma Vivo Ltd | Health & social care | 2024 |
| Dermafollic Company Ltd | Health & social care | 2020 |
| Dermaglo Skin Clinic Limited | Other services | 2023 |
| Dermalabs Skincare Limited | Wholesale & retail | 2022 |
| Dermalift Limited | Professional & scientific | 1999 |
| Dermis Cosmetic Healthcare Limited | Health & social care | 2022 |
| Dermrs Limited | Health & social care | 2015 |
| Deroad Holdings Ltd | Financial services | 2025 |
| Dervento Limited | Real estate | 2024 |
| Dervish Specifications Ltd. | Hospitality | 2015 |
| Dervishi 05 Ltd | Hospitality | 2024 |
| Derwent Property Management Ltd | Real estate | 2023 |
| Deseo Locking Systems Limited | Wholesale & retail | 2013 |
| Deserve Energy Ltd | Professional & scientific | 2025 |
| Deshi Sweets and Restaurant Ltd | Wholesale & retail | 2024 |
| Desi Chai Adha Ltd | Hospitality | 2025 |
| Desi Khana Yorkshire Ltd | Hospitality | 2018 |
| Desi Pavilion Limited | Hospitality | 2024 |
| Desi Wedeesi Ltd | Wholesale & retail | 2025 |
| Desiderius Global Ltd | Arts & recreation | 2026 |
| Design & Build Interiors Limited | Manufacturing | 2009 |
| Design & Graphic Limited | Manufacturing | 2003 |
| Design by Field Ltd | Professional & scientific | 2021 |
| Design by Foundry Ltd | Professional & scientific | 2018 |
| Design by Francesca Phillippa Limited | Other services | 2018 |
| Design by Gravity Ltd | Real estate | 2017 |
| Design Cycle Consulting Limited | Professional & scientific | 2015 |
| Design District Interiors Ltd | Professional & scientific | 2021 |
| Design Edge Ltd | Real estate | 2024 |
| Design Facility Solutions Limited | Professional & scientific | 2025 |
| Design Fire Consultants Ltd | Professional & scientific | 2010 |
| Design Five Ltd | Professional & scientific | 2022 |
| Design for Performance Consulting Ltd | Other services | 2019 |
| Design FYI Ltd | Construction | 2023 |
| Design House (Yorkshire) Limited | Construction | 2016 |
| Design Italia Limited | Wholesale & retail | 2007 |
| Design Life Limited | Real estate | 2003 |
| Design Management Contracts Limited | Real estate | 1987 |
| Design Matters Ltd | Information & communication | 2025 |
| Design Project Limited | Administrative & support | 2004 |
| Design Something More Limited | Professional & scientific | 2014 |
| Design T Limited | Manufacturing | 2024 |
| Design Time Holdings 2025 Limited | Financial services | 2025 |
| Design Tonic (Holdings) Limited | Financial services | 2023 |
| Design Tonic Limited | Professional & scientific | 2019 |
| Design WAX Ltd | Professional & scientific | 2020 |
| Design, Build & Refurb Properties Limited | Real estate | 2020 |
| Designarm (UK) Ltd | Construction | 2005 |
| Designed by DUO Ltd | Professional & scientific | 2014 |
| Designed in a Shed Limited | Arts & recreation | 2022 |
| Designing Choice Ltd. | Wholesale & retail | 2007 |
| Designit Media Limited | Professional & scientific | 2023 |