| Slyne Holdings Ltd | Financial services | 2023 |
| Slyne Lodge 2026 Ltd | Hospitality | 2026 |
| Slyne Stores Ltd | Wholesale & retail | 2015 |
| Slyne Woods Management Company Limited | Households | 1997 |
| SM OPS Tech Ltd | Professional & scientific | 2017 |
| Small World Consulting Limited | Professional & scientific | 2002 |
| Smalldesk Ltd | Information & communication | 2025 |
| Smart Choice Consulting Partnerships Limited | Professional & scientific | 2023 |
| Smart Renters Ltd | Real estate | 2023 |
| Smartship Couriers Ltd | Transport & logistics | 2025 |
| Smartstart (Catterall) Limited | Education | 2001 |
| Smirkin Limited | Information & communication | 2018 |
| Smith & Co Lancaster Limited | Professional & scientific | 2021 |
| Smith & Sons Vehicle Sales Ltd | Wholesale & retail | 2019 |
| Smith Steel Structures Ltd | Construction | 2025 |
| Smsjuice Limited | Information & communication | 2013 |
| Snuggli Protection Wear Limited | Wholesale & retail | 2020 |
| SO Training & Consulting Ltd | Education | 2020 |
| Sodashield (UK) Ltd | Manufacturing | 2012 |
| Sofias Candy Ltd | Wholesale & retail | 2024 |
| Sofimed Ltd | Health & social care | 2025 |
| Solera Group North Limited | Financial services | 2026 |
| Solid Soul Furniture Design Limited | Manufacturing | 2004 |
| Sonaspection International Limited | Manufacturing | 1986 |
| Sophia Holdings Limited | Other services | 2018 |
| Soterra Labs Limited | Agriculture & fishing | 2025 |
| Soul Food Street Kitchen Limited | Hospitality | 2021 |
| Soul Space Therapeutic Services Limited | Health & social care | 2021 |
| Soundsphere Limited | Hospitality | 2019 |
| South Cumbria Lets Ltd | Transport & logistics | 2019 |
| South East Block Paving Limited | Construction | 2005 |
| South East Paving Limited | Construction | 2016 |
| South Lakeland Damp Proof Coursing Limited | | 1984 |
| South Lakes Drain Jetting Limited | Administrative & support | 2018 |
| South Lakes Hotels Limited | Hospitality | 2004 |
| South Lakes Windows Limited | Construction | 2009 |
| Southeast Performing Arts Challenge Limited | Arts & recreation | 2025 |
| Southey Consultants Limited | Professional & scientific | 2007 |
| Southey Group Ltd | Financial services | 2022 |
| Southey Investco Limited | Financial services | 2022 |
| Southgate Industrial Estate Management Company Limited(The) | Households | 1986 |
| Southside School of Dance Limited | Arts & recreation | 2024 |
| SP & Co Accountancy Services (International) Ltd | Professional & scientific | 2016 |
| SP & Co Accountancy Services Limited | Professional & scientific | 2014 |
| Spacecadets Air Design Limited | Administrative & support | 2008 |
| Spacedna Consultancy Ltd | Information & communication | 2019 |
| Sparkle Cleaning Services (NW) Limited | Administrative & support | 2019 |
| Sparkles Hand Car Wash (Lancs) Ltd | Administrative & support | 2019 |
| Sparkles School of Dance Limited | Arts & recreation | 2024 |
| Sparklesun Ltd | Wholesale & retail | 2024 |
| Sparkloft Limited | Wholesale & retail | 2024 |
| SPC Construction Services Ltd | Professional & scientific | 2017 |
| Special Processing, Auditing and Consultancy Limited | Professional & scientific | 2012 |
| Specialist Outdoors Limited | Wholesale & retail | 2011 |
| Spectacular Science Club Ltd | Education | 2023 |
| Spectral Consulting Limited | Professional & scientific | 2016 |
| Spectrum Dynamics Community Interest Company | Administrative & support | 2022 |
| Speedydev Limited | Administrative & support | 2011 |
| Spencer Sutcliffe Security & Training Ltd | Administrative & support | 2019 |
| Spinrad Property Management Ltd. | Real estate | 2023 |
| Splitz Dance Academy Limited | Education | 2022 |
| Spokesy Properties Ltd | Real estate | 2024 |
| Sportivebike Limited | Arts & recreation | 2010 |
| Sportsfree Ltd | Wholesale & retail | 2023 |
| Spray Tech Finishing (NW) Ltd | Manufacturing | 2024 |
| Spring Orchard Limited | Professional & scientific | 2026 |
| Springs Dance & Fitness Limited | Arts & recreation | 2025 |
| SPW Contractors Limited | Construction | 2025 |
| Squires Sports Ltd | Hospitality | 2015 |
| SR Design & Build Ltd | Construction | 2011 |
| SRM Foods Limited | Hospitality | 2024 |
| Srsd Performance Limited | Arts & recreation | 2025 |
| ST Airtightness Ltd | Professional & scientific | 2025 |
| ST Anthony’S Close Management Company Limited | Households | 2021 |
| ST Enochs Garage Limited | Wholesale & retail | 2007 |
| ST John's Hospice Catering Limited | Hospitality | 2017 |
| ST John's Hospice Lancaster Limited | Wholesale & retail | 2010 |
| ST Johns Mews Lancaster Limited | Households | 1997 |
| ST Leonard Court RTM Company Limited | Households | 2020 |
| ST Louis Medical Ltd | Health & social care | 2023 |
| ST Marks (West Gorton) Limited | Wholesale & retail | 2017 |
| ST Thomas Lancaster Developments Ltd | Other services | 2018 |
| ST. John's Hospice Shops Limited | Wholesale & retail | 1990 |
| Stable END Curios Limited | Wholesale & retail | 2015 |
| Stableops Ltd | Information & communication | 2025 |
| Stackhouse Ltd | Financial services | 2018 |
| Staggland Ltd | Information & communication | 2010 |
| Stainton Property Holdings Ltd | Real estate | 2025 |
| Stalker Group Limited | Professional & scientific | 2026 |
| Standen Country Park Limited | Households | 1998 |
| Standen Gate (Lancaster) Management Company Limited | Households | 2002 |
| Stanhope Court Residents' Association Limited | Households | 1966 |
| Starlight Musical Theatre Company NW Ltd | Arts & recreation | 2025 |
| Starlight Stage School North West Ltd | Arts & recreation | 2025 |
| Stars of Bowness Ltd | Administrative & support | 2023 |
| Starvale Management and Technologies Limited | Information & communication | 1999 |
| Starvale Technical Systems Limited | Administrative & support | 2003 |
| Stasa Group Ltd | Wholesale & retail | 2026 |
| Statement Voting Ltd | Information & communication | 2018 |
| Station Court Residents Association (Lancaster) Limited | Households | 1991 |