| Davey West Limited | Hospitality | 2019 |
| David Armstrong Plumbing and Heating Limited | Construction | 2005 |
| David J Dickinson & Sons Limited | Construction | 2023 |
| David Kneale Financial Management Ltd. | Financial services | 2003 |
| David Millington Photography Limited | Professional & scientific | 2003 |
| Daviemacd Ltd | Information & communication | 2024 |
| Dawngreen Limited | Wholesale & retail | 1991 |
| Daxing Limited | Hospitality | 2024 |
| DC PNP Ltd | Professional & scientific | 2019 |
| DCW Sales & Enterprises Limited | Hospitality | 2026 |
| DDI Dance and Cheer Limited | Arts & recreation | 2024 |
| Ddno Limited | Hospitality | 2026 |
| Ddpay Ltd | Administrative & support | 1994 |
| Dean Halal Foods Limited | Extraterritorial | 2008 |
| Dean Maddison (Bentham) Limited | Transport & logistics | 2014 |
| Deco Publique CIC | Professional & scientific | 2026 |
| Deep 6 Marine Ltd | Professional & scientific | 2026 |
| Deidda Ltd | Health & social care | 2012 |
| Deliberate NW CIC | Other services | 2024 |
| Delicious Desserts (North West) Ltd | Real estate | 2018 |
| Delicious LA1 Ltd | Hospitality | 2019 |
| Delicious Lancaster Limited | Hospitality | 2021 |
| Dementia Pioneers CIC | Professional & scientific | 2012 |
| Dent Gone Automotive Ltd | Wholesale & retail | 2025 |
| Depth First Ltd | Other services | 2024 |
| Derbyshire Projects Limited | Construction | 2019 |
| Desert DEW Ltd | Transport & logistics | 2026 |
| Design Check Studio Ltd | Professional & scientific | 2026 |
| Desmond Hearn Limited | | 1964 |
| Deviant Skincare Ltd | Wholesale & retail | 2020 |
| Dflorencia Ltd | Wholesale & retail | 2024 |
| DG and E Limited | Construction | 2021 |
| DG Wedding Photography Limited | Professional & scientific | 2010 |
| DGM Financial Planning Ltd | Financial services | 2015 |
| DGT Research Limited | Manufacturing | 1997 |
| DH Eggs Ltd | Agriculture & fishing | 2016 |
| DH Properties (North West) Limited | Households | 2016 |
| DI Brooksbank Limited | Arts & recreation | 2003 |
| Dial a Curry Lancaster Limited | Hospitality | 2019 |
| Diamond Hair Limited | Other services | 2025 |
| Diamond Nails 37 Ltd | Other services | 2024 |
| Diamond Resorts AB Acquisition Company Limited | Professional & scientific | 2012 |
| Diamond Resorts Financial Services Limited | Financial services | 1985 |
| Diaotec Limited | Wholesale & retail | 2026 |
| Dickinson & Whitaker Limited | Construction | 2008 |
| Diesel (Snowhill) Limited | Real estate | 2013 |
| Dietcheck Limited | Information & communication | 1997 |
| Diggles Limited | Wholesale & retail | 1999 |
| Digiprobe Ltd | Manufacturing | 2024 |
| Digital Advisory Global Services Ltd | Professional & scientific | 2025 |
| Digital Alchemy Publishing Ltd | Information & communication | 2021 |
| Digital Beginnings Limited | Information & communication | 2014 |
| Digital Heard Ltd | Information & communication | 2023 |
| Digital Industries Limited | Wholesale & retail | 2021 |
| Digital Mountain Ltd | Information & communication | 2021 |
| Digital Transit Limited | Manufacturing | 2013 |
| Digitap Ltd | Information & communication | 2016 |
| Directlogic Ltd | Professional & scientific | 1996 |
| Distinctive Gardens Ltd | Administrative & support | 2006 |
| Diverse Nation Limited | Real estate | 2023 |
| Diverse Nation Sales and Lettings Limited | Real estate | 2024 |
| Divine Deli Holdings Limited | Financial services | 2013 |
| Divine Deli Supplies Limited | Wholesale & retail | 2007 |
| Divine Signs Limited | Professional & scientific | 2017 |
| Divine Wraps and Graphics Ltd | Professional & scientific | 2018 |
| Dixondale Limited | Real estate | 1982 |
| DJ Lewis Travel Ltd | Administrative & support | 2026 |
| DJR 1 Ltd | Professional & scientific | 2018 |
| DLJ Agri Supplies Limited | Wholesale & retail | 2016 |
| DM Dance Events Ltd | Arts & recreation | 2025 |
| DM Dance School Ltd | Arts & recreation | 2025 |
| DM Dance Studios Limited | Arts & recreation | 2016 |
| DM Property and Rentals Ltd | Real estate | 2025 |
| DM2 Management Limited | Financial services | 2025 |
| Dmitrytrans Ltd | Transport & logistics | 2024 |
| Dnormand Ltd | Hospitality | 2024 |
| DO & AW Holdings Ltd | Real estate | 2025 |
| Doctor Velo Ltd | Manufacturing | 2020 |
| Doctors Link Homecare Ltd | Health & social care | 2026 |
| Doctors Lodges Salford Ltd | Real estate | 2023 |
| Dodgeball Academy Ltd | Arts & recreation | 2023 |
| Dog Adventures Limited | Other services | 2019 |
| Dog Walkers' Guild Limited | Other services | 2017 |
| Doggy Adventures Ltd | Other services | 2024 |
| Dola Logistics Limited | Transport & logistics | 2015 |
| Dolforwyn Hall Ltd | Hospitality | 2021 |
| Dolphinholme Developments Ltd | Construction | 2020 |
| Dolward Properties Ltd | Real estate | 2022 |
| Dosa Villa Ltd | Hospitality | 2025 |
| Down to Earth Craft Gallery Limited | Wholesale & retail | 2012 |
| Downings Property Limited | Real estate | 2021 |
| Doxa Group Consulting Ltd | Information & communication | 2020 |
| DP Letting Limited | Real estate | 2016 |
| DP Trucks Limited | Wholesale & retail | 2014 |
| Dplc Investments Limited | Real estate | 2020 |
| DPM Energy Services Ltd | Construction | 2025 |
| DR Katherine Ltd | Health & social care | 2024 |
| DR. S.Soo Clinic Ltd | Health & social care | 2023 |
| Dragonzeno Limited | Hospitality | 2022 |
| Drainaway (Northwest) Limited | Construction | 2017 |