| Silverfox Consulting Ltd | Information & communication | 2018 |
| Simple Property Solutions Limited | Real estate | 2019 |
| Sinclair Interiors Limited | Wholesale & retail | 2005 |
| SIXTEEN80 Ltd | Wholesale & retail | 2003 |
| SJB Cleaning Ltd | Other services | 2019 |
| SJH Joinery Limited | Manufacturing | 2003 |
| Skinluxe Harrogate Ltd | Other services | 2024 |
| Skinmed Ltd | Wholesale & retail | 2001 |
| Skinvital Ltd | Wholesale & retail | 2017 |
| Skipton Road Services Limited | Households | 1996 |
| SKM Homes Ltd | Real estate | 2025 |
| Slingsby Tiling Ltd | Professional & scientific | 2021 |
| Smart Touch Autobodies Ltd | Wholesale & retail | 2016 |
| SMF701 Ltd | Agriculture & fishing | 2009 |
| Smile Hospitality Ltd | Hospitality | 2024 |
| Smith Mcbride Limited | Professional & scientific | 2011 |
| SMR Agrifor Ltd | Agriculture & fishing | 2022 |
| Smtr Properties Ltd | Real estate | 2026 |
| Snappy and Catchy Ltd | Hospitality | 2026 |
| Snoogle Limited | Other services | 2023 |
| SNS Property PVT Ltd | Real estate | 2021 |
| SOB UK Ltd | Administrative & support | 2021 |
| Soilworks Ltd | Extraterritorial | 2016 |
| Solar Republic Ltd | Construction | 2024 |
| Soli Entertainment Ltd | Arts & recreation | 2025 |
| Solum Saxum Consulting Ltd | Professional & scientific | 2024 |
| Solum Saxum Ltd | Professional & scientific | 2024 |
| Spa Gardens (Gainford) Management Company Limited | Households | 2025 |
| Spa Wealth Management Ltd | Professional & scientific | 2021 |
| Spark 365 Ltd | Information & communication | 2021 |
| Spark and Bind Ltd | Wholesale & retail | 2020 |
| Spark Health and Wellbeing Ltd | Health & social care | 2014 |
| Specialised Embroidery Services Ltd | Wholesale & retail | 2010 |
| Sporting Colours Limited | Extraterritorial | 1980 |
| Sports Ground Design Limited | Construction | 2012 |
| Sprout Gifts and Greenery Ltd | Wholesale & retail | 2026 |
| Square Kiwi Ltd | Administrative & support | 2016 |
| Ssorelle Ltd | Real estate | 2026 |
| SST Electrical Services Limited | Construction | 2022 |
| ST Roberts Close Management Company Limited | Households | 2014 |
| Stadia Vending Ltd | Wholesale & retail | 2025 |
| Stagelight Productions Ltd | Arts & recreation | 2026 |
| Stairs ETC Limited | Wholesale & retail | 2009 |
| Startmusic Ltd | Education | 2016 |
| Statler and Waldorf Limited | Information & communication | 2023 |
| Staveley Field D Ltd | Real estate | 2009 |
| Stay North Luxe Ltd | Real estate | 2026 |
| Stephen Kirk Nonclinical Drug Development Services Ltd | Professional & scientific | 2026 |
| Stephen Mcdine Limited | Financial services | 2004 |
| Sticker Lane Fisheries Limited | Hospitality | 2019 |
| Stockwell House Management Limited | Households | 1999 |
| Stone + Petal Ltd | Wholesale & retail | 2026 |
| Stoneacre Freehold Limited | Real estate | 2007 |
| Stonegarth Whitby Management Limited | Households | 2015 |
| Stow & Go Self Storage Ltd | Real estate | 2024 |
| Stray Away Ltd | Real estate | 2021 |
| Stray Business Services Limited | Professional & scientific | 2017 |
| Sttar Systems Ltd | Professional & scientific | 2012 |
| Studley Properties Ltd | Real estate | 2021 |
| Sudek Limited | Wholesale & retail | 2010 |
| Sugar Hill Farm Property Management Limited | Real estate | 1998 |
| Sun Nest Private Limited | Hospitality | 2020 |
| Sunlider Care Ltd | Health & social care | 2023 |
| Sunnyside K9 Academy Ltd | Other services | 2023 |
| Sunnyside K9 Grooming Ltd | Other services | 2023 |
| Supraseal Ltd | Wholesale & retail | 2026 |
| Swales Construction Ltd | Construction | 2019 |
| Swish Fibre Yorkshire Limited | Information & communication | 2021 |
| Switched on (Harrogate) Limited | Construction | 2008 |
| Switched on Energy Ltd | Professional & scientific | 2012 |
| SWM Capital Limited | Professional & scientific | 2023 |
| Symmetry of Health Limited | Health & social care | 2023 |
| SYN Retail Ltd | Professional & scientific | 2019 |
| Synnovia Limited | Professional & scientific | 2007 |
| Synpac Limited | Professional & scientific | 1984 |
| Syscol Limited | Information & communication | 2005 |
| Systems Training Support Ltd | Education | 2007 |
| SYSTEMS7 UK Ltd | Professional & scientific | 2025 |
| T & L Family Ltd | Real estate | 2026 |
| T C Consulting (Killinghall) Limited | Professional & scientific | 2003 |
| T J Electrical Contractors Ltd | Construction | 2022 |
| T L & C W Webster Ltd | Agriculture & fishing | 2014 |
| Tablewise Italia Ltd | Administrative & support | 2025 |
| Take IT Photography Ltd | Other services | 2016 |
| Talent House Group Limited | Administrative & support | 2021 |
| Tayberry Property Ltd | Real estate | 2022 |
| Taylley Estates Limited | Real estate | 2021 |
| Taylor’S Recovery&Rescue Ltd | Transport & logistics | 2026 |
| Team Food Limited | Professional & scientific | 2012 |
| Techforge Systems LLP | | 2024 |
| Technical Prospects Limited | Administrative & support | 2013 |
| Teckwise - Technology Solutions Ltd | Construction | 2023 |
| TED Kitchens and Bedrooms Ltd | Wholesale & retail | 2017 |
| Terra Green Yorkshire Ltd | Real estate | 2023 |
| Terra Vita Eternal Rest Ltd | Other services | 2026 |
| Testerdirect.Co.Uk Limited | Information & communication | 2023 |
| Tetragen (Knapton) (UK) Ltd | Energy | 2014 |
| Tetragen Holdings Limited | Energy | 2012 |
| TH Automotive Limited | Wholesale & retail | 2018 |
| THE 8020 Training Company Ltd | Administrative & support | 2023 |