| SLD Business Services UK Limited | Wholesale & retail | 2026 |
| Sledwrite Ltd | Information & communication | 2005 |
| Sleekcollectionsuk Ltd | Wholesale & retail | 2025 |
| Sleeke Entertainment Ltd | Arts & recreation | 2023 |
| Sleepfluent Ltd | Health & social care | 2025 |
| Slfirst Ltd | Wholesale & retail | 2025 |
| Slim&More Limited | Wholesale & retail | 2015 |
| Slimpharm Ltd | Wholesale & retail | 2025 |
| Slipdacademy Ltd | Education | 2026 |
| Slipstream Analytics Ltd | Administrative & support | 2014 |
| Sljgh Limited | Wholesale & retail | 2025 |
| SLL Law Limited | Professional & scientific | 2023 |
| Slllg. Ltd | Wholesale & retail | 2025 |
| SLM Building Construction Limited | Construction | 2017 |
| SLM Consulting Ltd | Professional & scientific | 2022 |
| SLR Energy NET Ltd | Construction | 2023 |
| Slumberpea Ltd | Wholesale & retail | 2025 |
| SM Digital Trading Ltd | Wholesale & retail | 2021 |
| SM House Ltd | Real estate | 2026 |
| SM Resolve Ltd | Professional & scientific | 2023 |
| Smanglow Company Limited | Wholesale & retail | 2025 |
| Smart Analysis Ltd | Information & communication | 2020 |
| Smart Cliniq AI Ltd | Information & communication | 2026 |
| Smart Comfort Homes Ltd | Real estate | 2026 |
| Smart Consulting Ltd | Administrative & support | 2025 |
| Smart Deal Mart Limited | Arts & recreation | 2026 |
| Smart Essentials Limited | Wholesale & retail | 2025 |
| Smart Integration AI Ltd | Information & communication | 2026 |
| Smart Life AI Tech Ltd | Wholesale & retail | 2024 |
| Smart Logistics Bridge Ltd | Transport & logistics | 2025 |
| Smart Money Management Ltd | Professional & scientific | 2019 |
| Smart Stone Investments Limited | Real estate | 2023 |
| Smartalpha Partners Ltd | Professional & scientific | 2017 |
| Smarter Techies Ltd | Information & communication | 2025 |
| Smartfun AI Technology Co., Ltd | Information & communication | 2025 |
| Smartgain Limited | Financial services | 2025 |
| Smartify Vault Ltd | Wholesale & retail | 2026 |
| Smartlet Properties NI Limited | Real estate | 2025 |
| Smartrad Creative Limited | Professional & scientific | 2020 |
| Smartvision Cinema Entertainment Co., Ltd | Information & communication | 2025 |
| Smartwind International Ltd | Manufacturing | 2024 |
| SMB Strategic Mining Consulting Ltd | Mining & quarrying | 2022 |
| SMG Management Asset Ltd | Extraterritorial | 2019 |
| SMG Technologies Ltd | Information & communication | 2015 |
| Smile Fashion Ltd | Extraterritorial | 2015 |
| Smile Property Solutions Ltd | Real estate | 2016 |
| Smile YI Xiao Ltd | Wholesale & retail | 2025 |
| Smilescore Ltd | Information & communication | 2026 |
| Smilestock Ltd | Wholesale & retail | 2025 |
| Smilogy Kids Ltd | Wholesale & retail | 2022 |
| Smith & Hobley Ltd | Construction | 2010 |
| Smith Construction (LON) Limited | Real estate | 2017 |
| Smith Property Partners Ltd | Real estate | 2025 |
| Smizeen Wellness Medical Research Center, UK Ltd | Wholesale & retail | 2025 |
| Smokingsforcoolpeople Ltd | Wholesale & retail | 2022 |
| Smooth Automation Services Ltd | Professional & scientific | 2025 |
| SMT Parts Supply Ltd | Administrative & support | 2015 |
| Smtpowerplant Ltd | Manufacturing | 2024 |
| Snail Kitty Ltd | Information & communication | 2025 |
| Snapre Group Ltd | Information & communication | 2026 |
| Snaptofig Ltd | Wholesale & retail | 2025 |
| Snaptop Group Ltd | Information & communication | 2024 |
| Snatched by Laura Limited | Wholesale & retail | 2024 |
| Snelston Medical Consulting Ltd | Professional & scientific | 2026 |
| Snhabib Ltd | Real estate | 2024 |
| Sniper Analytics Ltd | Information & communication | 2026 |
| SNM Capital Limited | Financial services | 2025 |
| Snoofly Ltd | Wholesale & retail | 2025 |
| Snowman Capital Ltd | Real estate | 2018 |
| Snowvideo Studio Ltd | Information & communication | 2025 |
| SNP IT Consultancy Ltd | Information & communication | 2025 |
| Snug Developments Ltd | Real estate | 2017 |
| SO Collagen Ltd | Wholesale & retail | 2020 |
| SO Ironing Bored Ltd | Administrative & support | 2021 |
| So-Ma Architects Ltd | Professional & scientific | 2024 |
| SOA Resolve Ltd | Professional & scientific | 2021 |
| Soapy Windows Limited | Administrative & support | 2014 |
| Soarpoint Group Ltd | Wholesale & retail | 2025 |
| Sobji Bazaar Ltd | Wholesale & retail | 2025 |
| SOC Blue Defence Labs Ltd | Education | 2025 |
| Socali Cantina Ltd | Hospitality | 2026 |
| Social Automation AI Ltd | Professional & scientific | 2023 |
| Social Housing Deals Limited | Administrative & support | 2019 |
| Social Spark IC Limited | Wholesale & retail | 2026 |
| Social Work Systems Ltd | Health & social care | 2023 |
| Socialist Publications Limited | Information & communication | 1997 |
| Society of Education Consultants Ltd | Education | 2011 |
| Sociowise Analytics Ltd | Information & communication | 2025 |
| Sock Vault Ltd | Wholesale & retail | 2018 |
| Sofar Electric Co., Ltd | Administrative & support | 2013 |
| Sofeez Store Ltd | Wholesale & retail | 2023 |
| Soft Gate Ltd | Wholesale & retail | 2026 |
| Soft Hearts Care Limited | Administrative & support | 2025 |
| Soft Living Limited | Wholesale & retail | 2017 |
| Softaware Tech Ltd | Information & communication | 2025 |
| Softrequest Ltd | Information & communication | 2021 |
| Sofun Essentials Limited | Wholesale & retail | 2025 |
| Sohaib Global Ltd | Information & communication | 2025 |
| Soho Ecomm Ltd | Wholesale & retail | 2023 |
| Soho Financials Ltd | Professional & scientific | 2020 |