| SIMBA404 Media Ltd | Manufacturing | 2025 |
| Simhandyman Limited | Construction | 2016 |
| Simmich Limited | Real estate | 2018 |
| Simone's Cake City Ltd | Manufacturing | 2020 |
| Simp Design Services Limited | Professional & scientific | 2013 |
| Simply Better Living Limited | Hospitality | 2025 |
| Simply Ecom Ltd | Wholesale & retail | 2023 |
| Simply Fresh & Simply Local Ltd | Professional & scientific | 2014 |
| Simply Necessities Ltd | Wholesale & retail | 2025 |
| Simprex Ltd | Information & communication | 2025 |
| Simpson Instruments Ltd | Manufacturing | 2026 |
| Simpson's Ventures Ltd | Wholesale & retail | 2026 |
| Sina Auto Parts Limited | Administrative & support | 2024 |
| Sinaury Ltd | Wholesale & retail | 2025 |
| Sinclair Mrinceton Ltd | Wholesale & retail | 2025 |
| Sindustria Ltd | Wholesale & retail | 2023 |
| Sing Energy Metals Ltd | Extraterritorial | 2026 |
| Singolo Wines Limited | Wholesale & retail | 2018 |
| Singularity Communication Consulting Limited | Wholesale & retail | 2025 |
| Singularityecho Ltd | Wholesale & retail | 2025 |
| Sino-Italian JZ Marine Engineering Co., Ltd. | Wholesale & retail | 2025 |
| Sino-Uk Ergothioneine Joint Research Center Ltd | Wholesale & retail | 2025 |
| Sino-Uk Joint Research Center for International Ltd | Wholesale & retail | 2025 |
| Sinoauto Co., Ltd | Wholesale & retail | 2024 |
| Sinoflex Industrial Solutions Co., Ltd. | Wholesale & retail | 2025 |
| Sinogum Group Ltd. | Administrative & support | 2019 |
| Sinoman International Group Co., Ltd | Administrative & support | 2009 |
| Sinotruk Global Co., Ltd | Administrative & support | 2022 |
| Sinovolt International Limited | Professional & scientific | 2025 |
| Sintra 7 Ltd | Real estate | 2008 |
| Sinuk Ltd | Information & communication | 2024 |
| Sinyan Entertainment Limited | Wholesale & retail | 2025 |
| Sinynn Technology Co., Limited | Wholesale & retail | 2025 |
| SIP of Warmth Limited | Wholesale & retail | 2026 |
| Siqian Ltd | Wholesale & retail | 2025 |
| SIR J.H.Biles & Co.Limited | Professional & scientific | 1967 |
| Siren Tears Ltd | Wholesale & retail | 2025 |
| Sirena Home Design Limited | Wholesale & retail | 2021 |
| Sirena Vista UK Limited | Wholesale & retail | 2026 |
| Sirens Hair Ltd | Other services | 2025 |
| Sirius Beam Ltd | Information & communication | 2025 |
| Siromonie Holdings Limited | Extraterritorial | 2017 |
| Siromonie Limited | Extraterritorial | 2025 |
| SIT Caribbean Limited | Hospitality | 2025 |
| Sitean Limited | Administrative & support | 2020 |
| Sitesys Ltd | Information & communication | 2026 |
| Sitewatchers Ltd | Administrative & support | 2024 |
| SITREP999 Ltd | Education | 2026 |
| Siyawela Creative Ltd. | Arts & recreation | 2022 |
| Siyi Technology Limited | Wholesale & retail | 2026 |
| SJ Kent Digital Ltd | Wholesale & retail | 2025 |
| Sjhaj Ltd | Wholesale & retail | 2025 |
| Sjlt Properties Limited | Real estate | 2019 |
| Sjtd Consulting Limited | Professional & scientific | 2026 |
| SK Brand Limited | Wholesale & retail | 2025 |
| SK Healthcare Pro Ltd | Health & social care | 2023 |
| Skarflow Ltd | Wholesale & retail | 2026 |
| SKB Leasing Group Limited | Administrative & support | 2025 |
| Skelva Limited | Wholesale & retail | 2025 |
| Skem Chad Media Ltd | Information & communication | 2025 |
| Skepsis Software Solutions Limited | Information & communication | 2022 |
| Skfirst Ltd | Wholesale & retail | 2025 |
| Skill UP Break Free Ltd | Education | 2025 |
| Skin Focused Ltd | Wholesale & retail | 2026 |
| Skin Sonata Limited | Wholesale & retail | 2023 |
| Skitteroo Ltd | Manufacturing | 2026 |
| Skittlepop Ltd | Wholesale & retail | 2024 |
| Skks MS Ltd | Wholesale & retail | 2025 |
| Skmh Group Ltd | Wholesale & retail | 2026 |
| SKN Global Ltd | Wholesale & retail | 2025 |
| Skryte Ltd | Information & communication | 2026 |
| Sky Band Limited | Wholesale & retail | 2021 |
| Sky Custom Box Ltd | Wholesale & retail | 2021 |
| Sky Domain Ltd | Wholesale & retail | 2026 |
| Sky Economy and Media Group Ltd | Information & communication | 2023 |
| Sky Link Media Ltd | Professional & scientific | 2026 |
| Sky Pinnacle Media Ltd | Information & communication | 2025 |
| Sky Protocol Limited | Extraterritorial | 2023 |
| Skycrest Homes Limited | Hospitality | 2025 |
| Skyfi Ltd | Manufacturing | 2025 |
| Skyforgeaerials Ltd | Professional & scientific | 2026 |
| Skyjet Technologies Ltd | Wholesale & retail | 2025 |
| Skylark Care Ltd | Health & social care | 2025 |
| Skyline International Trade Co., Ltd | Administrative & support | 2021 |
| SKYLINE6 Ltd | Wholesale & retail | 2025 |
| Skylord Limited | Other services | 2020 |
| Skylos Ltd | Wholesale & retail | 2025 |
| Skyparallel IS Network Technology Co., Ltd | Wholesale & retail | 2025 |
| Skypearl Solutions Limited | Transport & logistics | 2026 |
| Skypillarcollectibles Limited | Wholesale & retail | 2025 |
| Skyqj Ltd | Wholesale & retail | 2025 |
| Skyroam Ltd | Wholesale & retail | 2024 |
| Skytop E-Commerce Ltd | Wholesale & retail | 2025 |
| Skyverge Global Ltd | Wholesale & retail | 2025 |
| Skywell Trade Limited | Wholesale & retail | 2024 |
| SL Capital Ltd | Wholesale & retail | 2021 |
| SL Investments Group Limited | Professional & scientific | 2023 |
| Slatch Limited | Information & communication | 2024 |
| Slaystrandselite Ltd | Other services | 2025 |
| Slcoo Ltd | Extraterritorial | 2024 |