| Sales on Surge Limited | Professional & scientific | 2025 |
| Sales Plus Consultants Limited | Professional & scientific | 2003 |
| Salida Productions Ltd | Arts & recreation | 2008 |
| Salt & Cliff Apartments Limited | Real estate | 2026 |
| Saltlemon Limited | Wholesale & retail | 2025 |
| Salvalee Limited | Wholesale & retail | 2026 |
| SAM Services PVT Ltd | Information & communication | 2025 |
| SAM Stonehouse Ltd | Extraterritorial | 2017 |
| Samaras Healthcare Recruitment Ltd | Hospitality | 2021 |
| Samid Ltd | Construction | 2015 |
| Samiz Ltd | Wholesale & retail | 2024 |
| Samywise Ltd | Information & communication | 2024 |
| SAN Jose Services Limited | Professional & scientific | 2025 |
| Sana Idris Limited | Manufacturing | 2025 |
| Sanapakt UK Ltd | Wholesale & retail | 2025 |
| Sand Seeds Ltd | Information & communication | 2025 |
| Sandgross Limited | Other services | 2012 |
| Sangcoo Ltd | Wholesale & retail | 2025 |
| Sanhe Trading Co., Limited | Professional & scientific | 2024 |
| Sankara Media Ltd | Information & communication | 2025 |
| Sanmetals Ltd | Wholesale & retail | 2025 |
| Sanmsyeye Ltd | Wholesale & retail | 2026 |
| Sanpeliano Ltd | Wholesale & retail | 2024 |
| Santana Property Group Ltd | Real estate | 2025 |
| Santon Int'L Co., Ltd. | Extraterritorial | 2015 |
| Santuda JSL Ltd | Administrative & support | 2026 |
| Saoirseris Ltd | Wholesale & retail | 2025 |
| Saphus Ltd | Manufacturing | 2021 |
| Saphyr Agency Ltd | Information & communication | 2025 |
| Sapphire Group Holdings Limited | Administrative & support | 2016 |
| SAR Consultancy Limited | Health & social care | 2015 |
| Sara Ahavah Spiritual Inst Ltd | Education | 2021 |
| Sarafa Ltd | Information & communication | 2024 |
| Sarah New SFX Limited | Professional & scientific | 2024 |
| Sarah's Oddjob Services Ltd | Construction | 2021 |
| Sarahoasis Ltd | Wholesale & retail | 2026 |
| Sarahweeksconsultancy Ltd | Professional & scientific | 2024 |
| Saravana Limited | Wholesale & retail | 2020 |
| Sarb Management Ltd | Professional & scientific | 2009 |
| Sarben Limited | Hospitality | 2022 |
| Sardine International Trading Limited | Wholesale & retail | 2024 |
| Sareenah Ltd | Wholesale & retail | 2024 |
| Sarks.Services Ltd | Health & social care | 2021 |
| Saros & Sense Ltd | Wholesale & retail | 2024 |
| Sarqcy U.K. Limited | Manufacturing | 2022 |
| Sarrison Waieo Ltd | Wholesale & retail | 2025 |
| Saru Force Ltd | Information & communication | 2022 |
| SAS Tech Investment and Industrial Co., Ltd | Wholesale & retail | 2024 |
| Sassy Sienna Ltd | Wholesale & retail | 2025 |
| Satsyf Ltd | Information & communication | 2025 |
| Satteta Enterprises Limited | Information & communication | 2013 |
| Sauna World Ltd | Wholesale & retail | 2025 |
| Savile ROW Accessories Co. Ltd | Wholesale & retail | 2025 |
| Savina Clothing Co., Ltd | Manufacturing | 2025 |
| Savvy Mosaic Solutions Ltd | Information & communication | 2025 |
| Savvylogical Ltd | Information & communication | 2025 |
| Savx Ltd | Health & social care | 2024 |
| SAW Deals Limited | Wholesale & retail | 2025 |
| Saxoncats Maine Coons Ltd | Agriculture & fishing | 2024 |
| Saxonvale UK Limited | Health & social care | 2026 |
| SB Cyprus Luxury Escapes Ltd | Hospitality | 2025 |
| SB Online Distributions Ltd | Wholesale & retail | 2025 |
| SBC Corporation Co., Ltd | Extraterritorial | 2023 |
| SBE Hospitality Limited | Hospitality | 2024 |
| SBJ Trading Limited | Wholesale & retail | 2026 |
| SBR Northwest Ltd | Professional & scientific | 2017 |
| Sbyraee Ltd | Other services | 2025 |
| SC Sun Ltd | Wholesale & retail | 2025 |
| Scaleframe Ltd | Professional & scientific | 2025 |
| Scaletific Ltd | Information & communication | 2018 |
| Scaleupops Ltd | Information & communication | 2024 |
| Scalient Limited | Information & communication | 2025 |
| Scalon Higarden Ltd | Wholesale & retail | 2025 |
| Scalorion Visuals Ltd | Information & communication | 2026 |
| Scandinavia Stories Ltd | Professional & scientific | 2013 |
| SCD Insight Consulting Ltd. | Information & communication | 2017 |
| Scene Magazine Media CIC | Information & communication | 1998 |
| SCH ENF Ltd | Professional & scientific | 2024 |
| Schalikon Kapellen Ltd | Wholesale & retail | 2025 |
| Schengen Journey Ltd | Professional & scientific | 2025 |
| Schengjun Ltd | Wholesale & retail | 2025 |
| Schneider International Limited | Manufacturing | 2011 |
| Scholarpro Ltd | Education | 2025 |
| Scholarshipsads Ltd | Wholesale & retail | 2024 |
| SCI Guys LLP | | 2020 |
| Sciencehouse Consultancy Ltd | Professional & scientific | 2022 |
| Scientific Open Access Publishing Ltd | Information & communication | 2026 |
| Scootflow Ltd | Wholesale & retail | 2025 |
| Scopevyn Intake Maps Ltd | Information & communication | 2026 |
| Scorp Venture Ltd | Other services | 2019 |
| Scott Wells Mini Fashion Limited | Wholesale & retail | 2026 |
| Scoutswap C.I.C. | Information & communication | 2026 |
| Screen Cycle Limited | Other services | 2021 |
| Screen Free Mind Ltd | Education | 2025 |
| Screen Revive Ltd | Information & communication | 2019 |
| Screensure Diagnostic Limited | Health & social care | 2026 |
| Scrigno Limited | Professional & scientific | 2007 |
| Scuderia Bruce Investments Ltd | Financial services | 2021 |
| Scuderia Bruce Property Ltd | Real estate | 2021 |
| Sculptor Aesthetics Ltd | Health & social care | 2021 |