| SBK Consulting Limited | Professional & scientific | 2021 |
| SC Accountancy Ltd | Professional & scientific | 2019 |
| SC Advisors Ltd | Professional & scientific | 2019 |
| SC Property Ltd | Administrative & support | 2019 |
| SCH Installations Ltd | Construction | 2017 |
| Sciente-Alliance Ltd | Professional & scientific | 2019 |
| SCK Homes Ltd | Construction | 2020 |
| SCM Flooring Ltd | Construction | 2023 |
| Scot-Core Ltd | Wholesale & retail | 2021 |
| Screwshop Ltd | Wholesale & retail | 2017 |
| SD Promotional Products Limited | Wholesale & retail | 2018 |
| SDC Bathrooms Limited | Other services | 2010 |
| SDS Fire Protection Ltd | Public administration | 2023 |
| SDS North Ltd | Construction | 2026 |
| SDT Carpentry Ltd | Construction | 2019 |
| Sea Change Property Development Limited | Construction | 2023 |
| Sealants Direct Ltd | Construction | 2022 |
| Sean Mccormick Ltd | Construction | 2015 |
| Securasite Limited | Manufacturing | 2011 |
| Secure Solutions UK Limited | Professional & scientific | 2001 |
| Select Auto Parts Ltd | Wholesale & retail | 2018 |
| Sellgoods Limited | Wholesale & retail | 2015 |
| Sentry Medical Assessments Ltd | Public administration | 2019 |
| Serenity KBB Ltd | Wholesale & retail | 2023 |
| Serenity Kitchens and Bathrooms Ltd | Manufacturing | 2015 |
| Serenity Property Ltd | Real estate | 2017 |
| Serenity Ultrasound Services Ltd | Professional & scientific | 2023 |
| Serge in Sales Ltd | Wholesale & retail | 2022 |
| SGT Structures Limited | Construction | 2015 |
| Shadow Vaporz Ltd | Wholesale & retail | 2015 |
| Shaks Convenience Store Ltd | Wholesale & retail | 2022 |
| Shan Best Food Ltd | Wholesale & retail | 2024 |
| Shankly Investments Limited | Financial services | 2021 |
| Shankly Property Developments Limited | Construction | 2021 |
| Sharon Billingham Limited | Hospitality | 2025 |
| Sharshamar Limited | Health & social care | 2023 |
| Shearline Steel Strip Limited | Manufacturing | 2003 |
| Sheena Hamilton New AGE Educational Trust | Education | 2024 |
| Sheet Anchor Commercial Property Limited | Real estate | 2023 |
| Sheet Anchor Evolve (Birmingham) Limited | Real estate | 2021 |
| Sheet Anchor Evolve (EK) Limited | Extraterritorial | 2024 |
| Sheet Anchor Evolve (London) Limited | Real estate | 2015 |
| Sheet Anchor Evolve (Oxford) Limited | Real estate | 2024 |
| Sheet Anchor Evolve (Screen Co) Limited | Extraterritorial | 2024 |
| Sheet Anchor Evolve Group Limited | Real estate | 2024 |
| Sheet Anchor Evolve Limited | Real estate | 2013 |
| Sheet Anchor Evolve Retail Limited | Real estate | 2024 |
| Sheet Anchor Evolve Ventures Limited | Real estate | 2024 |
| Sheet Anchor Investments 2 Limited | Real estate | 2018 |
| Sheet Anchor Investments Limited | Real estate | 2014 |
| Sheet Anchor Northampton 1 Ltd | Real estate | 2022 |
| Sheet Anchor Northampton 2 Ltd | Real estate | 2022 |
| Sheet Anchor OES UK Limited | Energy | 2026 |
| Sheet Anchor Onsite Energy Solutions Limited | Financial services | 2026 |
| Sheet Anchor Properties (Screen Co) Limited | Professional & scientific | 2024 |
| Sheet Anchor Properties Limited | Real estate | 1988 |
| Sheet Anchor Property Investments 2 Limited | Real estate | 2018 |
| Sheet Anchor Property Investments 3 Limited | Other services | 2026 |
| Sheet Anchor Property Investments Ltd | Real estate | 2017 |
| Sheet Anchor Retail Investments Limited | Real estate | 2022 |
| SHG (Dog Kennel Lane) Limited | Real estate | 2026 |
| SHG Holdco Limited | Real estate | 2022 |
| Shirley-Rose Ltd | Health & social care | 2022 |
| Shls Property Group Limited | Construction | 2021 |
| Shoker Assets Ltd | Real estate | 2026 |
| Shoreline Wright Ltd | Construction | 2020 |
| Shropshire CAD Services Ltd | Professional & scientific | 2014 |
| Shropshire Drylining Services Ltd | Construction | 2020 |
| Shropshire Lifestyle Medicine Limited | Health & social care | 2024 |
| Signature Pipework Installations Ltd | Manufacturing | 2015 |
| Siltherm UK Ltd | Professional & scientific | 2016 |
| Silver-Tec Ltd | Manufacturing | 2014 |
| Silverhowe Ltd | Professional & scientific | 2025 |
| Silverlox Ltd | Other services | 2020 |
| Simworx Attractions Limited | Manufacturing | 2026 |
| Site Cranes Ltd | Administrative & support | 2006 |
| Siviter Greenfield Group Limited | Professional & scientific | 2007 |
| Siviter Wargames Limited | Wholesale & retail | 2014 |
| Siviter Yates Limited | Professional & scientific | 2009 |
| Siyona Limited | Health & social care | 2021 |
| SJ Property Solutions Ltd | Real estate | 2023 |
| SJJ Distribution Limited | Wholesale & retail | 2024 |
| SJK Utilities Ltd | Construction | 2015 |
| SJN Roofing and Driveways Limited | Construction | 2017 |
| SJO Engineering Ltd | Professional & scientific | 2023 |
| SK Barbers Shop Ltd | Other services | 2025 |
| Skaldic Ltd | Health & social care | 2025 |
| SKB Breaks Ltd | Wholesale & retail | 2026 |
| SKD Tapes Limited | Extraterritorial | 2020 |
| Skin 24/7 Limited | Wholesale & retail | 2021 |
| Sky Blue Vape Ltd | Wholesale & retail | 2018 |
| Skynost Investments | Financial services | 2021 |
| SL Accountancy Services Ltd | Professional & scientific | 2019 |
| SL Mortgages Ltd | Financial services | 2025 |
| SL Realisations 2026 Ltd | Manufacturing | 2005 |
| Slack JAW Games Ltd | Information & communication | 2025 |
| Slaters of Kingswinford Ltd | Other services | 2017 |
| SLB Enterprises Limited | Hospitality | 2023 |
| Sleep Tight Serviced Accommodation Ltd | Real estate | 2024 |
| Smart Bodyshop Solutions (Cardiff) Ltd | Wholesale & retail | 2019 |