| Simplin Ltd | Information & communication | 2023 |
| SKI Sail City Ltd | Real estate | 2019 |
| Skillcash Media Limited | Information & communication | 2026 |
| Skin Solutions South Devon Ltd | Wholesale & retail | 2020 |
| Sky Whale Games Company Ltd | Wholesale & retail | 2024 |
| Sleevegrange Limited | Real estate | 1979 |
| Smoozle and Bone Ltd | Manufacturing | 2021 |
| SN Construction (Devon) Limited | Professional & scientific | 2007 |
| Somatic Shift Ltd | Information & communication | 2024 |
| Sophie P Co Limited | Other services | 2019 |
| Sorley Management Company Limited | Real estate | 2011 |
| Soteria Global Services Ltd | Information & communication | 2022 |
| South Devon Bass Guide Ltd | Agriculture & fishing | 2024 |
| South Devon Camping Limited | Hospitality | 2024 |
| South Devon Chilli Farm Ltd | Agriculture & fishing | 2004 |
| South Devon Estate Planning Ltd | Professional & scientific | 2020 |
| South Devon Fishers Limited | Agriculture & fishing | 1997 |
| South Devon Garden Railway Group Limited | Arts & recreation | 2016 |
| South Hams Area Wellbeing Community Interest Company | Health & social care | 2018 |
| South Hams Brewery Ltd | Manufacturing | 2017 |
| South Hams Business Park Management Company Limited | Households | 1991 |
| South Hams Car Spares Limited | Wholesale & retail | 2017 |
| South Hams Construction & Developments Ltd | Construction | 2024 |
| South Hams Development Company Ltd | Real estate | 2020 |
| South Hams Eco Developments Ltd | Professional & scientific | 2013 |
| South Hams Estates Limited | Real estate | 2016 |
| South Hams Flying Club | Arts & recreation | 2025 |
| South Hams Foods Ltd | Hospitality | 2026 |
| South Hams Staycations Ltd | Hospitality | 2021 |
| South Hams Urology Ltd | Health & social care | 2024 |
| South Moor Endsleigh Ltd | Real estate | 2017 |
| South Moor Equine Limited | Real estate | 2021 |
| South Moor Holdings Ltd | Financial services | 2024 |
| South Moor Limited | Professional & scientific | 2008 |
| South West Foreign Exchange Ltd | Financial services | 2008 |
| South West Studio Ltd | Professional & scientific | 2014 |
| South West Wine School Limited | Wholesale & retail | 2018 |
| Southdown Farm (Amenities) Limited | Households | 1989 |
| Southwater Court Limited | Real estate | 2006 |
| SPACE4U Ltd | Real estate | 2021 |
| Spanton.Co.Uk Limited | Information & communication | 2009 |
| Speak Tech ENG Ltd | Education | 2024 |
| Speaking HR Ltd | Professional & scientific | 2017 |
| Speedway Investments Limited | Real estate | 2023 |
| Spion Lodge Management Company Ltd | Real estate | 2020 |
| Sportsmb Limited | Wholesale & retail | 2019 |
| Springbrook Enterprises Limited | Hospitality | 2007 |
| Springfield Drive Management Company Ltd | Administrative & support | 2019 |
| Squirrel Design Solutions Limited | Professional & scientific | 2016 |
| ST Anne's Chapel Cottages Management Limited | Professional & scientific | 2012 |
| ST. Elmo House Management Company Limited | Real estate | 1989 |
| Stancombe Cross Farm Ltd | Agriculture & fishing | 2019 |
| Stancombe Property Limited | Real estate | 2011 |
| Stanjoy Engineering Consultants Limited | Real estate | 1946 |
| Stanton Court Management Company (Loddiswell) Limited | Households | 1999 |
| Star Bay View Ltd | Hospitality | 2024 |
| Starboard Tack Ltd | Health & social care | 2015 |
| Start Bay Bungalows Limited | Hospitality | 2003 |
| Start Bay Ltd | Hospitality | 2026 |
| Start Bay Studio Ltd | Health & social care | 2020 |
| Start Point Events Ltd | Administrative & support | 2022 |
| Start Point Finance Ltd | Financial services | 2007 |
| Start Point Law Limited | Professional & scientific | 2016 |
| Stephen Page and Partners Limited | Real estate | 2014 |
| STG Engineering Limited | Professional & scientific | 2008 |
| Stirling Consultants UK Limited | Professional & scientific | 2005 |
| Stokeley Barton Management Company Limited | Other services | 2000 |
| Stokenham Explorers Ltd | Health & social care | 2024 |
| Stopher Design Partnership Limited | Professional & scientific | 2004 |
| Storm Construction (SW) Ltd | Administrative & support | 2016 |
| Stuart Barrett Consulting Ltd | Financial services | 2022 |
| Studio Four (SW) Ltd | Construction | 2017 |
| Sucker Punch Kickboxing CIC | Education | 2025 |
| SUE Johnston LAB Ltd | Manufacturing | 2024 |
| Summer Heritage Estates Limited | Construction | 2025 |
| Summercross Estates Ltd | Households | 2023 |
| Summerfield Collections Ltd | Construction | 2024 |
| Sunny Cliff Management Company Ltd | Households | 2017 |
| Surety Xchange Ltd | Administrative & support | 2025 |
| Surf Coach International Ltd | Arts & recreation | 2011 |
| Suscircle Limited | Professional & scientific | 2025 |
| Swindells Property Ltd | Real estate | 2023 |
| T B International Consulting Limited | Extraterritorial | 2009 |
| T.C.E.F. Limited | Hospitality | 1998 |
| T24 Seven Limited | Manufacturing | 2003 |
| Tacket Wood Lane Management Company Limited | Households | 2022 |
| Tally HO! Coaches Holdings Limited | Transport & logistics | 2025 |
| Tally HO! Coaches Limited | Transport & logistics | 2004 |
| Tarifa Management Limited | Households | 2001 |
| Tax & Accounts (SW) Ltd | Professional & scientific | 2013 |
| Taylor Developments Ltd | Construction | 2022 |
| Taylor Land & Property Ltd | Construction | 2025 |
| Taylored Games Ltd | Wholesale & retail | 2017 |
| TBP Properties Limited | Real estate | 2025 |
| TCL Consultants Ltd | Financial services | 2020 |
| TCR Consultants Ltd | Information & communication | 2009 |
| Teign (LQE Cornwall) Limited | Financial services | 2021 |
| Teign Construction Solutions Limited | Professional & scientific | 2022 |
| Teign Consulting & Surveying Limited | Professional & scientific | 2018 |
| Teign Group Ltd | Financial services | 2026 |