| Ship to Shore Designs Ltd | Manufacturing | 2022 |
| Shire Homes (Holdings) Limited | Financial services | 2025 |
| Shire Homes Joinery Manufacturing Ltd | Manufacturing | 2023 |
| Shunt Culture Ltd | Arts & recreation | 2024 |
| Sicily by Heart Ltd | Hospitality | 2025 |
| Sidas UK Ltd | Wholesale & retail | 2002 |
| Sight Advice South Lakes | Health & social care | 2011 |
| Silecroft Country Park Limited | Hospitality | 2017 |
| Sillfield Farm Markets Limited | Administrative & support | 2005 |
| Sillfield Farm Products Limited | Wholesale & retail | 2002 |
| Sillfield Farms Barrow Ltd | Wholesale & retail | 2013 |
| Silva Barns Limited | Professional & scientific | 2019 |
| Silver Assembly Ltd | Wholesale & retail | 2022 |
| Simia Marine Limited | Manufacturing | 2023 |
| Simon and Louise Budd Limited | Wholesale & retail | 2006 |
| Simon Kent Furniture Agencies Limited | Wholesale & retail | 2013 |
| Simon Radcliffe Limited | Health & social care | 2013 |
| Simply VEG Limited | Wholesale & retail | 2026 |
| Simpson Construction (Building Services) Limited | Construction | 2014 |
| Sinclair Prime Properties Ltd | Construction | 2023 |
| Sisters in the Wild Ltd | Administrative & support | 2022 |
| Site Radio Limited | Wholesale & retail | 2026 |
| Sitec Support Services Limited | Construction | 2002 |
| Sixpump Ltd | Real estate | 2021 |
| Sixtytwo Media Limited | Professional & scientific | 2023 |
| Sizergh Energy Ltd | Energy | 2012 |
| Sizergh Properties Limited | Real estate | 1995 |
| SJ Dalton Limited | Professional & scientific | 2018 |
| SJK Consultancy Ltd | Professional & scientific | 2023 |
| Skelcies Ltd | Professional & scientific | 2026 |
| Skelsmergh Lane Management Limited | Real estate | 2024 |
| Skwiot Auto Services Ltd | Wholesale & retail | 2020 |
| Skyline Walking Holidays Limited | Administrative & support | 2024 |
| Skyscape IT Limited | Information & communication | 2018 |
| Slewtic Limited | Manufacturing | 2017 |
| Sljos Capital Limited | Financial services | 2026 |
| Smart Tiles Limited | Wholesale & retail | 2010 |
| Smartphone Defence Limited | Information & communication | 2010 |
| Softwash Group Ltd | Administrative & support | 2024 |
| Sold OUT Records Limited | Information & communication | 2024 |
| Sole and Trail Ltd | Other services | 2026 |
| Solerco Ltd | Wholesale & retail | 2023 |
| Solid Roots Limited | Professional & scientific | 1997 |
| Soundsmith Limited | Construction | 2005 |
| South Lakeland Property Limited | Real estate | 2024 |
| South Lakes Citizens Advice Bureau | Information & communication | 2007 |
| South Lakes Dance Company Ltd | Arts & recreation | 2026 |
| South Lakes Health and Fitness Ltd | Arts & recreation | 2019 |
| South Lakes Holdings Ltd | Real estate | 2025 |
| South Lakes Lifting Services Limited | Professional & scientific | 2018 |
| South Lakes Mobility Limited | Wholesale & retail | 2013 |
| South Lakes Retreat Lodges Limited | Hospitality | 2017 |
| South Lakes Tattoo Ltd | Other services | 2025 |
| Spaciality Limited | Transport & logistics | 2013 |
| Sparkle Sisters Cleaning Ltd | Administrative & support | 2025 |
| Spatial Data Limited | Professional & scientific | 2021 |
| Specialist Communication and Psychology Services Limited | Education | 2023 |
| Spinal Homecare Holdings Limited | Administrative & support | 2015 |
| Spinal Homecare Topco Holdings Limited | Financial services | 2022 |
| Spinning Jennies Ltd | Administrative & support | 2021 |
| Spital Caravans Ltd | Hospitality | 2022 |
| Sport Maison Limited | Arts & recreation | 2015 |
| Sport Outdoor Limited | Wholesale & retail | 2024 |
| Sport Works Holdings Ltd | Education | 2019 |
| Sport Works Limited | Arts & recreation | 2009 |
| Sportivos Limited | Education | 2022 |
| Sports Recovery Kendal Ltd | Health & social care | 2018 |
| Sports Solar Ltd | Wholesale & retail | 2020 |
| Springstone Homes Limited | Real estate | 2016 |
| Spurrett Bespoke Eyecare Limited | Health & social care | 2013 |
| Stables Thompson & Briscoe Ltd | Professional & scientific | 2007 |
| Stack Distribution Limited | Wholesale & retail | 2014 |
| Stagborough Consulting Limited | Professional & scientific | 2017 |
| Stanley Graham Group Limited | Construction | 2016 |
| Stanway's Structural Solutions Limited | Extraterritorial | 2023 |
| Staveley & Kentmere Limited | Construction | 2018 |
| Staveley Healthcare Limited | Wholesale & retail | 2004 |
| Staveley Mill Yard Limited | Real estate | 2022 |
| Staveley Park Limited | Real estate | 2017 |
| Stephen Baines Groundworks Limited | Construction | 2025 |
| Stephen Raven (Kentmere) Limited | Construction | 2005 |
| Steve Defreitas Limited | Other services | 2015 |
| Steve Jones Electrical Limited | Construction | 2011 |
| Steve Mitchinson & Co Ltd | Construction | 2023 |
| Steve Price Electrical Services Limited | Construction | 2017 |
| Steve Selby Building Contractors Limited | Construction | 2005 |
| Steven Barber Photography Limited | Professional & scientific | 2007 |
| Steven Cross Finishing Limited | Construction | 2018 |
| Stevens Leadership Consulting Limited | Professional & scientific | 2017 |
| Stewart Surveyors Ltd | Professional & scientific | 2017 |
| Still Point Osteopathy Limited | Health & social care | 2002 |
| Stockbeck Ltd | Information & communication | 2014 |
| Stockgate Management Ltd. | Extraterritorial | 2014 |
| Stone and Slate Investments Limited | Real estate | 2017 |
| Stone World Limited | Manufacturing | 2002 |
| Storer Shiels Limited | Professional & scientific | 2017 |
| Storm Limited | Other services | 1995 |
| Stramongate Dental Care Limited | Health & social care | 2009 |
| Stramongate Properties Limited | Construction | 1984 |
| Street Couriers Ltd | Transport & logistics | 2015 |