| Coker Landscaping & Fencing Limited | Administrative & support | 2022 |
| Cole Couriers Ltd | Transport & logistics | 2018 |
| Colin Murray UK Ltd | Hospitality | 2018 |
| Collaborative Counselling Limited | Health & social care | 2023 |
| Collative Limited | Other services | 2025 |
| Collative Studios Limited | Wholesale & retail | 2025 |
| Collings & Sons Logistics Ltd | Transport & logistics | 2019 |
| Colourbridge South West Limited | Administrative & support | 2015 |
| Coloured by Madison Limited | Other services | 2026 |
| Colt (London) Limited | Other services | 1990 |
| Combined Marine Services Ltd | Manufacturing | 2019 |
| Companionship & Enablement Services Ltd | Administrative & support | 2025 |
| Compass Property Maintenance Ltd | Construction | 2026 |
| Conchus Ltd | Wholesale & retail | 2018 |
| Contractors Holdings Limited | Financial services | 2024 |
| Cooper's Vision PUB Company Limited | Hospitality | 2019 |
| Coral Cove Ltd | Hospitality | 2024 |
| Core Block Management Ltd | Households | 2026 |
| Core FRA Solutions Ltd | Public administration | 2025 |
| Coredocs Limited | Manufacturing | 2025 |
| Cornwall and Devon Transmissions Limited | Manufacturing | 1975 |
| Cornwall Canoes Ltd | Wholesale & retail | 1988 |
| Cornwood Cats Limited | Other services | 2004 |
| Corrosion & Technology Consultants UK Limited | Construction | 2023 |
| Countrymans Butchery Limited | Wholesale & retail | 2013 |
| Countrymans Choice Farmshop Limited | Wholesale & retail | 2013 |
| Courtney Evans Holdings Limited | Professional & scientific | 2010 |
| Coverstructures Commercial Limited | Other services | 2006 |
| Cowsberry Farm Development Limited | Real estate | 2019 |
| Cowslip Developments Ltd | Real estate | 2018 |
| Cozy Grain Ltd | Hospitality | 2025 |
| CRD Bath Limited | Construction | 2013 |
| CRD Utilities Ltd | Construction | 2026 |
| Creative Garage Conversions (SW) Ltd | Construction | 2020 |
| CTS Energy Ltd | Construction | 2026 |
| Custom Carpentry and Construction SW Ltd | Construction | 2026 |
| Custom GAS Ltd | Construction | 2022 |
| Custom Group SW Ltd | Construction | 2021 |
| Custom Reworx Limited | Manufacturing | 2014 |
| Cygnus Marine Holdings Limited | Energy | 1993 |
| D Lish Vapes Ltd | Wholesale & retail | 2023 |
| D&A Property SW Ltd | Real estate | 2025 |
| D&T Waste Solutions Limited | Water & waste | 2026 |
| Dairycentre Limited | Professional & scientific | 2006 |
| Dame Hannah Rogers Trust 2019 Limited | Health & social care | 2019 |
| Dampbusters SW Ltd | Construction | 2025 |
| Darling Property Management Limited | Households | 2026 |
| Darling Studio Limited | Other services | 2026 |
| Darmouth Pizza Ltd | Hospitality | 2025 |
| Dartmoor Décor Ltd | Construction | 2024 |
| Daveswasteaway Ltd | Water & waste | 2023 |
| Dawn Patrol Ltd | Administrative & support | 2025 |
| Deadline Distribution Services Limited | Transport & logistics | 2000 |
| Demon International Ltd | Manufacturing | 1964 |
| Dennett Estates Ltd | Real estate | 2024 |
| Designed Space Limited | Professional & scientific | 2003 |
| Devlin Trust Community Interest Company | Arts & recreation | 2023 |
| Devon & Cornwall Timber Windows Ltd | Financial services | 2022 |
| Devon Carpentry Solutions Ltd | Manufacturing | 2025 |
| Devon GP Ltd | Health & social care | 2024 |
| Devon Kitchens Limited | Extraterritorial | 2016 |
| Devon Law Limited | Professional & scientific | 2014 |
| Devon Lean Limited | Professional & scientific | 2012 |
| Devon Pens Ltd | Extraterritorial | 2017 |
| Devon Pressure Washers Ltd | Manufacturing | 2010 |
| Devon Tees Ltd | Manufacturing | 2020 |
| Devon Tennis Ltd | Arts & recreation | 2024 |
| Devon Window Care Limited | Construction | 2009 |
| DEVONCARPENTERS83 Ltd | Construction | 2021 |
| Devonshire Tea Ltd | Wholesale & retail | 1985 |
| Diamond Accounts Bookkeeping & Payroll Limited | Professional & scientific | 2023 |
| Diamond Drainage Limited | Construction | 2026 |
| Digger Streetwear Limited | Wholesale & retail | 2007 |
| Dince Hill (Holdings) Limited | Wholesale & retail | 1974 |
| Distiller's CUT Ltd | Wholesale & retail | 2023 |
| Distribution UK 2025 Ltd | Wholesale & retail | 2025 |
| DK Plumbing & Heating SW Ltd Limited | Construction | 2024 |
| DL Motorsport Parts Ltd. | Wholesale & retail | 2007 |
| DMR Collation Limited | Professional & scientific | 2015 |
| DMS Bricklaying Limited | Construction | 2015 |
| DNA Windscreens Ltd | Wholesale & retail | 2025 |
| DNR Fire Protection Ltd | Construction | 2025 |
| Dodovens Motor Services Ltd | Wholesale & retail | 2025 |
| Dolce Plymouth Ltd | Hospitality | 2026 |
| Doohikee Ltd | Wholesale & retail | 2019 |
| Dorian Property Solutions Ltd | Construction | 2026 |
| Dorothy & Richard LLP | | 2008 |
| Drainblock Services Ltd | Administrative & support | 2025 |
| Drains & Tank Services Ltd | Construction | 2024 |
| Drains & Tank Solutions Southwest Ltd | Construction | 2023 |
| Drake Contracting Ltd | Construction | 2025 |
| Drake Holdings SW Ltd | Financial services | 2025 |
| Drake Resources Ltd | Construction | 2026 |
| Drakes Plaice Fish and Chips Ltd | Hospitality | 2024 |
| DRC Project Services Ltd | Professional & scientific | 2025 |
| Dream TV & Film Catering Ltd | Hospitality | 2018 |
| Drenbre Ltd | Construction | 2017 |
| Drive With John Limited | Education | 2025 |
| DT Media Limited | Information & communication | 1999 |
| DTM Global Holdings Limited | Information & communication | 2011 |