| Shiners Cleaning & Support Services Limited | Administrative & support | 2005 |
| Shiners Cleaning and Support Services (Holdings) Limited | Professional & scientific | 2012 |
| Shiny Blocks Ltd | Wholesale & retail | 2023 |
| Shoaib Online Ltd | Wholesale & retail | 2022 |
| Shoni Shokai UK Limited | Wholesale & retail | 2011 |
| Shopefay Ltd | Wholesale & retail | 2023 |
| Shore Retail Limited | Professional & scientific | 2002 |
| Short & Tall Coffee Ltd | Wholesale & retail | 2022 |
| Short Stay Rentals Ltd | Real estate | 2023 |
| Shreeji Select Ltd | Wholesale & retail | 2025 |
| Shubhmangal Limited | Real estate | 2022 |
| Sibo & Anshika Estate's Ltd | Real estate | 2020 |
| Sidhu Capital Limited | Real estate | 2024 |
| Sidmouth 1965 Limited | Extraterritorial | 2014 |
| Signature Appliances Ltd | Wholesale & retail | 2020 |
| Signike Ltd | Wholesale & retail | 2023 |
| Silk Route Travel Ltd | Administrative & support | 2025 |
| Silkmore Developments Limited | Real estate | 2020 |
| Sillusions Ltd | Information & communication | 2018 |
| Silver Delights Limited | Wholesale & retail | 2011 |
| Silver Eclipse Ltd | Health & social care | 2022 |
| Silverhall Global Wealth Limited | Financial services | 2024 |
| Silverhall Wealth Limited | Financial services | 2024 |
| Silverline Motor Hire Limited | Wholesale & retail | 2024 |
| Silverstone Property Investment Ltd | Real estate | 2022 |
| Simgad Ltd | Real estate | 2017 |
| Simon Bhatti Real Estate Ltd | Real estate | 2024 |
| Simon Colds Limited | Administrative & support | 2016 |
| Simple Health Kitchen Holdings Limited | Financial services | 2020 |
| Simple Marylebone Limited | Hospitality | 2020 |
| Simply Capital Partners Ltd | Professional & scientific | 2015 |
| Simplyspaces Ltd | Construction | 2022 |
| Simranjit Ltd | Wholesale & retail | 2025 |
| Sinclair Properties (UK) Limited | Professional & scientific | 2013 |
| Singh Delivers Ltd | Transport & logistics | 2024 |
| Singh Properties London Limited | Construction | 2022 |
| Singularium Limited | Professional & scientific | 2022 |
| Sinharay Engineering Services Ltd. | Professional & scientific | 2012 |
| SIP by SIP Alcohol Limited | Wholesale & retail | 2021 |
| SIR Accountancy Services UK Ltd | Professional & scientific | 2018 |
| Sirabhi Properties Ltd | Real estate | 2022 |
| Siri's Aesthetics Ltd | Other services | 2020 |
| Sisi (UK) Ltd | Wholesale & retail | 2012 |
| Sister Energy Limited | Financial services | 2016 |
| Siteology Studio Ltd | Information & communication | 2026 |
| Sizlers RES Limited | Hospitality | 2012 |
| SJ Growth Real Estate Limited | Financial services | 2025 |
| SJ Strategy Ltd | Professional & scientific | 2025 |
| SJB Wealth Management Ltd | Financial services | 2021 |
| Sjpa Sales Ltd | Wholesale & retail | 2025 |
| SK ENG. Limited | Professional & scientific | 2010 |
| SK Petroleum Limited | Wholesale & retail | 2009 |
| SK Scooters Limited | Wholesale & retail | 2024 |
| SKA Coliving Limited | Real estate | 2025 |
| SKA Consultancy Limited | Professional & scientific | 2025 |
| SKA Goldhawk Ltd | Real estate | 2022 |
| SKA Homes Ltd | Real estate | 2017 |
| SKJ Limited | Extraterritorial | 2022 |
| Skmann Group Ltd | Real estate | 2022 |
| Sky Corporate Secretary Limited | Professional & scientific | 2011 |
| Sky CP Limited | Information & communication | 2015 |
| Sky Europe Limited | Information & communication | 2015 |
| Sky Finance Europe Limited | Administrative & support | 2015 |
| Sky Global Media Limited | Information & communication | 2014 |
| Sky Global Services Limited | Administrative & support | 2020 |
| Sky Group Limited | Information & communication | 2015 |
| Sky Healthcare Scheme 2 Limited | Professional & scientific | 2013 |
| Sky Home Communications Limited | Information & communication | 2004 |
| Sky International Limited | Information & communication | 2014 |
| Sky IP International Limited | Administrative & support | 2010 |
| Sky IQ Limited | Information & communication | 2010 |
| Sky Mobile Services Limited | Information & communication | 2015 |
| Sky News Limited | Information & communication | 2015 |
| Sky Ocean Ventures Partner Limited | Administrative & support | 2018 |
| Sky Pension Plan Trustees Limited | Professional & scientific | 2022 |
| Sky Publications Limited | Information & communication | 1995 |
| Sky SNA Limited | Information & communication | 2010 |
| Sky SNI Limited | Information & communication | 2013 |
| Sky SNI Operations Limited | Information & communication | 2013 |
| Sky Studios Limited | Information & communication | 2002 |
| Sky Studios Productions Limited | Information & communication | 2010 |
| Sky Surfaces UK Ltd | Construction | 2025 |
| Sky UK Investments Limited | Administrative & support | 2020 |
| Skyline Property Enterprise Ltd | Real estate | 2020 |
| Skynet Vision Limited | Information & communication | 2002 |
| Skyshowtime Limited | Professional & scientific | 2021 |
| Slaters International Funeral Directors Ltd | Other services | 2017 |
| Slaveev Ltd | Transport & logistics | 2024 |
| Sldg Limited | Professional & scientific | 2026 |
| Slice & Sizzle Ltd | Hospitality | 2026 |
| Slick Construction Ltd | Construction | 2012 |
| Smart and Simple Assist Limited | Professional & scientific | 2020 |
| Smart Home GAS Ltd | Construction | 2021 |
| Smart House Plus Ltd | Construction | 2017 |
| Smartfood Chef Limited | Hospitality | 2016 |
| Smartmate Ltd | Hospitality | 2023 |
| Smash Your Exam Ltd | Education | 2017 |
| Smash-Cut International Productions Ltd | Information & communication | 2017 |
| SMD Freelance Sales Limited | Administrative & support | 2024 |
| Smhg Limited | Real estate | 2025 |