| Sahannah Properties Ltd | Real estate | 2022 |
| SAI Best Foods Ltd | Wholesale & retail | 2025 |
| SAI Danu Ltd | Public administration | 2022 |
| SAI Praveen Limited | Information & communication | 2025 |
| SAI YUM Foods Private Ltd | Wholesale & retail | 2020 |
| Saif Holdings Ltd | Professional & scientific | 2019 |
| Salm Ltd | Extraterritorial | 2013 |
| Saltfleetby Energy Europe Limited | Mining & quarrying | 2020 |
| Salubi Company Ltd | Health & social care | 2020 |
| Salubi Homes Ltd | Construction | 2023 |
| SAM Smart Hair Ltd | Information & communication | 2022 |
| Samakab Network Ltd | Health & social care | 2023 |
| Samfix Ltd | Construction | 2021 |
| Sami Kebabs Ltd | Hospitality | 2025 |
| Samkav Limited | Real estate | 2018 |
| Samrina Partners Limited | Real estate | 2016 |
| Samsarakitchens Limited | Hospitality | 2024 |
| SAN & ROW Ltd | Wholesale & retail | 2019 |
| Sana Adnan Limited | Real estate | 2019 |
| Sand Crawler Industries Ltd | Information & communication | 2013 |
| Sandkands Limited | Professional & scientific | 2015 |
| Sandridge Investments Limited | Real estate | 2004 |
| Sandro Builders Ltd | Construction | 2026 |
| Sankhyaglobal Limited | Information & communication | 2018 |
| Santa Siena Trading SA Limited | Financial services | 2014 |
| Santo Tech Limited | Wholesale & retail | 2020 |
| Santosh Limited | Real estate | 2014 |
| Sapra UK Enterprise Limited | Wholesale & retail | 2018 |
| Sara 22 Limited | Hospitality | 2023 |
| Sara-Int Accounting and Immigration Limited | Professional & scientific | 2018 |
| Sara-Int Renovations Ltd | Construction | 2018 |
| SARAH121HOOPER Ltd | Professional & scientific | 2015 |
| Sardar Enterprises UK Limited | Real estate | 2015 |
| Sardar Investments Limited | Real estate | 1978 |
| Sardar Properties Limited | Other services | 1976 |
| Sash Repair London Ltd | Construction | 2025 |
| Sasha Aesthetics Ltd | Other services | 2023 |
| Sasta Business Services Ltd | Wholesale & retail | 2014 |
| Sava Construction Services Ltd | Construction | 2018 |
| Saving for the Children Ltd | Health & social care | 2014 |
| Savitur Consulting Limited | Professional & scientific | 2016 |
| Savitur Limited | Wholesale & retail | 2020 |
| SB Coaches Ltd | Transport & logistics | 2023 |
| Sbiv Limited | Construction | 2026 |
| SBS Real Estate Ltd. | Real estate | 2018 |
| Sc.Scenic (Carpentry Services) Ltd | Manufacturing | 2011 |
| Scalecapacity UK Ltd | Information & communication | 2025 |
| Scanplanbuild Ltd | Professional & scientific | 2023 |
| Scendo Limited | Arts & recreation | 2026 |
| Schofield Rigging Ltd | Information & communication | 2012 |
| SCI Lilas Limited | Extraterritorial | 2004 |
| Scott's Personal Training Limited | Education | 2016 |
| Scratch Golf Ltd | Administrative & support | 2023 |
| Scribe Technologies Limited | Information & communication | 2022 |
| Scripted Voices Limited | Information & communication | 2022 |
| Scrubbing in Healthcare Ltd | Education | 2023 |
| SD AG Global Limited | Wholesale & retail | 2026 |
| SDS Distributors Ltd | Transport & logistics | 2022 |
| Seatconsulting Limited | Information & communication | 2013 |
| SEB Car Parts Recycling Ltd | Wholesale & retail | 2020 |
| Sebix Construction Ltd | Construction | 2025 |
| Secure Investing Limited | Professional & scientific | 2014 |
| Seeforme Limited | Information & communication | 2026 |
| Seehar Limited | Construction | 2024 |
| Seehorizons Limited | Construction | 2026 |
| Seema M Ltd | Manufacturing | 2019 |
| Seema MO Properties Limited | Real estate | 2020 |
| Seemi.Zee Fashion Ltd | Manufacturing | 2022 |
| SEG Partners Limited | Manufacturing | 2024 |
| Sehmi KBR Ltd. | Wholesale & retail | 2017 |
| Sekhon Property Ltd | Real estate | 2011 |
| SEL Electrical Ltd | Construction | 2020 |
| Self IT Solutions UK Ltd | Information & communication | 2021 |
| Selfmadecat Ltd | Wholesale & retail | 2024 |
| Sensonido Limited | Professional & scientific | 2000 |
| Sensor Media Hub Ltd | Information & communication | 2018 |
| Sentinel Guard Services Ltd | Administrative & support | 2026 |
| Senura Civil Engineering UK PVT Ltd | Construction | 2024 |
| Seny Multi Recruitment Ltd | Administrative & support | 2023 |
| Serve Smart Training Ltd | Administrative & support | 2020 |
| SEW Royale Ltd | Wholesale & retail | 2020 |
| SFA Associates Limited | Real estate | 2009 |
| Sfamw Group Ltd | Wholesale & retail | 2026 |
| SGB London Ltd | Wholesale & retail | 2025 |
| Shahzab Chaudhry Medical Services Limited | Health & social care | 2006 |
| Shajj Partners Ltd | Information & communication | 2018 |
| Shamba Land Limited | Professional & scientific | 2010 |
| Shamco International Recruitment Limited | Administrative & support | 2011 |
| Shams Urban Ltd | Real estate | 2025 |
| Shape House London Ltd | Arts & recreation | 2024 |
| Sharma & Agnihotri Ltd | Information & communication | 2010 |
| Sharma Properties Limited | Real estate | 2016 |
| Sharp Thinkers Limited | Information & communication | 2023 |
| Shashwat Infosec Limited | Information & communication | 2024 |
| SHE Seals Deals Ltd | Wholesale & retail | 2024 |
| Sheri Dens Bespoke Garden Buildings Limited | Construction | 2022 |
| Sheridan Carpentry Limited | Construction | 2023 |
| Sheridan Developers Limited | Construction | 2022 |
| SHH Propco Ltd | Real estate | 2022 |
| Shield UA Ltd | Health & social care | 2023 |