| Shree Shyam & CH Tekram's Academy Ltd | Financial services | 2025 |
| Shree Shyam Housing Limited | Real estate | 2023 |
| Sicilian Dream Homes Ltd | Real estate | 2012 |
| Signature Porsche Limited | Wholesale & retail | 2017 |
| Silsden Assured Properties (1990) Limited | Extraterritorial | 1990 |
| Silsden Assured Properties (1991) Limited | Extraterritorial | 1990 |
| Silver Birch Projects Ltd | Construction | 2019 |
| Silver Linings Investments Limited | Real estate | 2024 |
| Silverburn Consultancy Ltd | Information & communication | 2022 |
| Silverburn Homes Ltd | Real estate | 2019 |
| Silverspring Lettings Limited | Real estate | 2017 |
| Silverspring Maintenance Limited | Construction | 2024 |
| Silverstone Residential Ltd | Real estate | 2026 |
| Simon Battersby Consulting Limited | Information & communication | 2009 |
| Simply Groups Limited | Administrative & support | 2001 |
| Simpsonmoor Property Ltd | Real estate | 2025 |
| Sinclair & Sinclair Property Ltd | Real estate | 2025 |
| Singhrey Limited | Real estate | 2018 |
| SIR George Martin Trust Company Limited | Professional & scientific | 1954 |
| Sirris.Io Limited | Professional & scientific | 2016 |
| SIX Five Business Services Limited | Professional & scientific | 2017 |
| SJ Services Engineering Limited | Construction | 2018 |
| SJH Business Developments Limited | Real estate | 2017 |
| Skaife Properties Limited | Real estate | 2021 |
| Skale Digital Limited | Professional & scientific | 2026 |
| Skeye Photography and Surveys Ltd | Professional & scientific | 2015 |
| Skinners Limited | Administrative & support | 1998 |
| Skipton Road Management Company Limited | Households | 2002 |
| Skirfa Limited | Extraterritorial | 2017 |
| SL Cooper Career and Leadership Coaching Ltd | Other services | 2023 |
| Slotphase Residents Management Limited | Households | 1988 |
| Smart Home Renewables Limited | Construction | 2017 |
| Smartangle Limited | Administrative & support | 1999 |
| Smartcredit Limited | Financial services | 2005 |
| Smartsearch International Limited | Financial services | 2019 |
| Smartsouls Ltd | Professional & scientific | 2007 |
| Smitt Limited | Manufacturing | 2025 |
| Smokevac Ltd | Construction | 2016 |
| Snaffle Equestrian Clothing Ltd | Wholesale & retail | 2023 |
| SNK Property Development and Management Ltd | Real estate | 2018 |
| Sofa Source Direct Limited | Wholesale & retail | 2017 |
| Solace Bidco Limited | Financial services | 2023 |
| Solace Cleanco Limited | Financial services | 2024 |
| Solace Topco Limited | Financial services | 2024 |
| Solace Vlnco Limited | Financial services | 2024 |
| Solaure Limited | Real estate | 2025 |
| Solor Consulting Limited | Information & communication | 2025 |
| Solutions AS a Service Limited | Information & communication | 2017 |
| SOM Restaurants Ltd | Hospitality | 2010 |
| Some Yellow Ltd | Professional & scientific | 2022 |
| Sonic Invest Ltd | Real estate | 2018 |
| Sonnetty Ltd | Manufacturing | 2007 |
| Sorento Takeaway Limited | Hospitality | 2019 |
| Sorted Garages Limited | Manufacturing | 2016 |
| Soul&Co Ltd | Professional & scientific | 2019 |
| Sous LE NEZ Limited | Hospitality | 2001 |
| South East Rope Access Limited | Construction | 2023 |
| Southern House Investments (Bradford) Limited | Construction | 1955 |
| Southfield Road (Burley-In-Wharfedale) Property & Management Company Limited | Households | 1972 |
| Sowden Electrical Services Limited | Construction | 2009 |
| SP Signature Living Limited | Real estate | 2026 |
| SPA190 Limited | Professional & scientific | 2021 |
| Spaces Management Consultants Ltd | Professional & scientific | 2019 |
| Specialist Dental Care Limited | Health & social care | 2007 |
| Specialist Office Services Limited | Construction | 1999 |
| Speculo Glass Specialists Ltd | Construction | 2019 |
| Speed for Sport Training Ltd | Education | 2026 |
| Spellman Care Limited | Professional & scientific | 2023 |
| Spence and Jackson Limited | Professional & scientific | 2017 |
| Spencer & Dunnett Ltd | Hospitality | 2023 |
| Sphk Ltd | Wholesale & retail | 2025 |
| Spice Fusion Indian Takeaway Limited | Hospitality | 2023 |
| Spicy Pizza Idle Limited | Other services | 2019 |
| Spiderlift Access Ltd | Administrative & support | 2021 |
| Spinning Mill Court Management Company Limited | Real estate | 1997 |
| Splat Ltd | Professional & scientific | 2016 |
| Spomul Ltd | Professional & scientific | 2023 |
| Spooner Food Machinery Engineering Company Limited | Professional & scientific | 1947 |
| Spooner Industries Limited | Manufacturing | 1959 |
| Spooner Robinson Engineering Limited | Professional & scientific | 1920 |
| Sportive Breaks Ltd | Administrative & support | 2015 |
| Spotty Property Ltd | Real estate | 2017 |
| Springfield House Management Company (Silsden) Limited | Households | 2004 |
| Square Financial Limited | Financial services | 2005 |
| SRL Asset Management Ltd | Administrative & support | 2016 |
| SRL Estates Ltd | Real estate | 2018 |
| SRS UK Holdings Ltd | Hospitality | 2018 |
| ST Michael's Property SPV Limited | Real estate | 2022 |
| ST Ninian Ltd | Health & social care | 2017 |
| Staceway Limited | Professional & scientific | 2025 |
| Staffbank Outsourcing Solutions Limited | Administrative & support | 2025 |
| Stancliffes Ltd | Manufacturing | 2019 |
| Standard Fitness Ltd | Arts & recreation | 2020 |
| Stansil Home Ltd | Real estate | 2023 |
| Stansil Smile Ltd | Health & social care | 2018 |
| Star GEM Property Services Ltd | Real estate | 2024 |
| Star Hand Carwash Ilkley Limited | Other services | 2023 |
| State Media Vision Limited | Wholesale & retail | 2017 |
| STC Developments Ltd | Real estate | 2015 |
| Steam Systems Ltd | Extraterritorial | 2026 |