| Roph Limited | Real estate | 2011 |
| Rory Mcphee Hair Ltd | Professional & scientific | 2023 |
| Rossenco Properties Ltd | Real estate | 2025 |
| Rossett Beauty Ltd | Other services | 2017 |
| Rouge Beauty Boutique (Ilkley) Ltd | Health & social care | 2013 |
| Rouge Beauty Spa (Yorkshire) Limited | Other services | 2011 |
| Rowan Scott Limited | Manufacturing | 2014 |
| Rowanbank Caravan Park Ltd | Real estate | 2015 |
| Rowland Agar (Wholesale Butchers) Limited | Manufacturing | 1994 |
| Rowuk Ltd | Arts & recreation | 2016 |
| ROY and Jean Atkinson Limited | Other services | 1997 |
| ROY Pickard Ltd | Transport & logistics | 2014 |
| RQ Psychology Limited | Health & social care | 2018 |
| RSA Constructions Ltd | Wholesale & retail | 2016 |
| RSB IT UK Limited | Professional & scientific | 2018 |
| RSM Media LLP | | 2009 |
| Rstu Advisory Limited | Professional & scientific | 2026 |
| RT Realisation Ltd | Water & waste | 1997 |
| Ruenthai Massage and Wellbeing Limited | Other services | 2020 |
| Rusc Limited | Information & communication | 2002 |
| RWC Trees, Stumps & Logs Ltd | Agriculture & fishing | 2015 |
| Rymo Limited | Extraterritorial | 1980 |
| S & a Holdings (Leeds) Ltd | Financial services | 2020 |
| S & J Tate Properties LLP | | 2008 |
| S & R East Midlands Limited | Hospitality | 2017 |
| S & S FOX Properties Limited | Real estate | 2019 |
| S B Building & Landscaping Ltd | Construction | 2023 |
| S FOX Joinery Limited | Construction | 2013 |
| S J Properties & Lettings Limited | Construction | 2016 |
| S K Plumbing of Ilkley Limited | Construction | 2010 |
| S Solar UK Ltd | Construction | 2023 |
| S&J Global Property Group Ltd | Real estate | 2025 |
| S&L Holdco Limited | Administrative & support | 2020 |
| S&W Fire Protect Ltd | Public administration | 2024 |
| S.Garth Diving Ltd | Manufacturing | 2021 |
| SA Porter Ltd | Information & communication | 2025 |
| Sacred Hearts Wealth Limited | Real estate | 2025 |
| Safe Digital Care Ltd | Administrative & support | 2025 |
| Saimahs Indian Ltd | Hospitality | 2023 |
| Sakam Property Holdings Limited | Real estate | 2017 |
| Sakam Property LLP | | 2017 |
| Sakis Holdings Ltd | Professional & scientific | 2017 |
| Salesamp Limited | Administrative & support | 2024 |
| Sally Wood FD Services Limited | Professional & scientific | 2022 |
| Saltaire Road Developments Limited | Real estate | 2003 |
| Salutem Security Limited | Administrative & support | 2018 |
| Samanta Private Ltd | Hospitality | 2018 |
| Samuel Higham Limited | Administrative & support | 2015 |
| Sanders Psychology Ltd | Professional & scientific | 2012 |
| Sandgate House (Management Company) Limited | Households | 2021 |
| Sapere Books Ltd | Information & communication | 2017 |
| Sarvaya Properties Ltd | Real estate | 2026 |
| Sassy Lissy Ltd | Real estate | 2024 |
| Satvik Services Limited | Administrative & support | 2007 |
| Sauls of Yorkshire Limited | Real estate | 2021 |
| Savvy Pixel A.I Automation Ltd | Information & communication | 2025 |
| SB Architecture Studio Ltd | Professional & scientific | 2022 |
| Scalebor Limited | Real estate | 2014 |
| Scalepoint Limited | Professional & scientific | 1996 |
| Scanlift UK Limited | Transport & logistics | 2000 |
| School Wood Farm Holiday Home Park LLP | | 2007 |
| Schoolyard Gardens Management Company Limited | Households | 2025 |
| SD Prestige & Performance Limited | Wholesale & retail | 2011 |
| SDH Consultants Limited | Professional & scientific | 2009 |
| Search Buddy Limited | Professional & scientific | 2021 |
| Sebastian Jones Properties Ltd | Real estate | 2025 |
| Sebastian Lucy Limited | Wholesale & retail | 2024 |
| Secret Garden Glamping Limited | Professional & scientific | 2024 |
| Secret Garden Ventures Limited | Professional & scientific | 2024 |
| Sedlak Co Ltd | Professional & scientific | 2020 |
| Seed King Ltd | Wholesale & retail | 2016 |
| Sefton Drive Management Limited | Households | 1984 |
| Sembol Ltd | Health & social care | 2014 |
| Sense of Space (Ilkley) Limited | Professional & scientific | 2003 |
| September 17 Limited | Real estate | 2024 |
| Sercle Limited | Information & communication | 1994 |
| Sereia Skincare Limited | Wholesale & retail | 2020 |
| Sersa Records Limited | Professional & scientific | 2019 |
| Service Insights Ltd | Professional & scientific | 2016 |
| Servitor Limited | Information & communication | 2001 |
| Sevensun Agency Limited | Professional & scientific | 2018 |
| SGB Medical Ltd | Wholesale & retail | 2011 |
| SGB Packaging Services Ltd | Professional & scientific | 2021 |
| Shapla (Wetherby) Ltd | Hospitality | 2015 |
| Sharder Limited | Real estate | 2022 |
| Sharrock Construction Limited | Construction | 2000 |
| Shaw Consultants Ltd | Professional & scientific | 2025 |
| Shawarma Fattoush Ltd | Hospitality | 2019 |
| Shay Court (Bradford) Management Company Limited | Households | 1988 |
| Sheerin Engineering Limited | Information & communication | 2014 |
| Sheldon Television Ltd | Information & communication | 2023 |
| Shepherdess Business Services Limited | Professional & scientific | 2021 |
| Sherbourne Jaques Limited | Real estate | 2025 |
| Sherburn 2 Estate Management Ltd | Households | 2018 |
| Shieldpath Ltd | Financial services | 2026 |
| Shimmerdisc International Limited | Manufacturing | 2013 |
| Shisei Limited | Information & communication | 2017 |
| SHO Accountancy Limited | Professional & scientific | 2017 |
| Shoo Social Media Ltd | Information & communication | 2014 |
| Shoreham Ltd | Real estate | 2021 |